Associations of MALAT1 and its functional single nucleotide polymorphisms with cancer

Cao, Lina; Yan, Guo-Dong; Yu, Shumin; Li, Fuju; Su, Zhixia; Hou, Xiaofan; Xiao, Jing; Tian, Tian

doi:10.1016/j.prp.2022.153988

Cited by 12 publications

(7 citation statements)

References 35 publications

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“…However, it may be linked to a higher risk of colorectal cancer, which needs more studies for further validation [73]. Other MALAT1 functional variants have shown associations with the risk of cancer, for example, colorectal cancer (rs619586, rs664589, and rs1194338) and hepatocellular cancer (rs619586), as confirmed by the recent meta-analysis conducted by Cao et al [74]. It is worth noting that the discrepancies between different studies and ours could be due to the ethnic differences, variable sample sizes, types of study populations (hospital-based vs. general population), study designs, and types of cancer, among others.…”

Section: Discussionmentioning

confidence: 81%

Angio-Long Noncoding RNA MALAT1 (rs3200401) and MIAT (rs1061540) Gene Variants in Ovarian Cancer

Fawzy,

Ibrahiem,

Osman

et al. 2024

Epigenomes

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The genotyping of long non-coding RNA (lncRNA)-related single-nucleotide polymorphisms (SNPs) could be associated with cancer risk and/or progression. This study aimed to analyze the angiogenesis-related lncRNAs MALAT1 (rs3200401) and MIAT (rs1061540) variants in patients with ovarian cancer (OC) using “Real-Time allelic discrimination polymerase chain reaction” in 182 formalin-fixed paraffin-embedded (FFPE) samples of benign, borderline, and primary malignant ovarian tissues. Differences in the genotype frequencies between low-grade ovarian epithelial tumors (benign/borderline) and malignant tumors and between high-grade malignant epithelial tumors and malignant epithelial tumors other than high-grade serous carcinomas were compared. Odds ratios (ORs)/95% confidence intervals were calculated as measures of the association strength. Additionally, associations of the genotypes with the available pathological data were analyzed. The heterozygosity of MALAT1 rs3200401 was the most common genotype (47.8%), followed by C/C (36.3%). Comparing the study groups, no significant differences were observed regarding this variant. In contrast, the malignant epithelial tumors had a higher frequency of the MIAT rs1061540 C/C genotype compared to the low-grade epithelial tumor cohorts (56.7% vs. 37.6, p = 0.031). The same genotype was significantly higher in high-grade serous carcinoma than its counterparts (69.4% vs. 43.8%, p = 0.038). Multivariate Cox regression analysis showed that the age at diagnosis was significantly associated with the risk of OC development. In contrast, the MIAT T/T genotype was associated with a low risk of malignant epithelial tumors under the homozygote comparison model (OR = 0.37 (0.16–0.83), p = 0.017). Also, MIAT T allele carriers were less likely to develop high-grade serous carcinoma under heterozygote (CT vs. CC; OR = 0.33 (0.12–0.88), p = 0.027) and homozygote (TT vs. CC; OR = 0.26 (0.07–0.90), p = 0.034) comparison models. In conclusion, our data provide novel evidence for a potential association between the lncRNA MIAT rs1061540 and the malignant condition of ovarian cancer, suggesting the involvement of such lncRNAs in OC development.

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Section: Discussionmentioning

confidence: 81%

Angio-Long Noncoding RNA MALAT1 (rs3200401) and MIAT (rs1061540) Gene Variants in Ovarian Cancer

Fawzy,

Ibrahiem,

Osman

et al. 2024

Epigenomes

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“…MALAT1 lncRNA has recently been discovered to have a significant part in an expanding spectrum of illnesses and their progressions, including diabetes and its related complications [ 36 , 37 ], inflammatory disorders such as Coronavirus disease 2019 (COVID-19) [ 38 , 39 ], and sepsis, in addition to its well-known function in the progression of cancers [ 40 , 41 ]. A pleiotropic role for MALAT1 in controlling gene expression and signaling pathways under different pathophysiological situations is suggested by the fact that it is ubiquitously linked with genomes in the areas crucial for transcriptional regulation as well as RNA processing [ 42 ].…”

Section: Discussionmentioning

confidence: 99%

“…According to evidence, structural changes caused by genetic variations in lncRNA may affect how it expresses or functions, which might participate in tumor development [ 47 ]. In recent years, studies have also revealed that genetic polymorphisms of MALAT1 have susceptibility to cancers [ 31 , 32 , 40 ]. In our study, the cohort of LUAD demographics and fundamental traits were comparable to those of previous Asian cohort [ 48 , 49 ]; these cohort also showed that LUAD patients with an EGFR mutation were more likely to be female, never-smokers, and to have better cell differentiation than the EGFR wild-type group.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the clinical significance of long non-coding RNA MALAT1 genetic variants in human lung adenocarcinoma

Lin,

Lu,

Hsieh

et al. 2024

Aging

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Lung adenocarcinoma (LUAD) is the most frequent histological subtype of lung cancer, which is the most common malignant tumor and the main cause of cancer-related mortality globally. Recent reports revealed that long non-coding RNA (lncRNA) of metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) plays a crucial role in tumorigenesis and metastasis development in lung cancer. However, the contribution of MALAT1 genetic variants to the development of LUAD is unclear, especially in epidermal growth factor receptor (EGFR) mutation status. In this study, 272 LADC patients with different EGFR status were recruited to dissect the allelic discrimination of the MALAT1 polymorphisms at rs3200401, rs619586, and rs1194338. The findings of the study showed that MALAT1 polymorphisms rs3200401, rs619586, and rs1194338 were not associated to LUAD susceptibility; however, rs3200401 polymorphisms was significantly correlated to EGFR wild-type status and tumor stages in LUAD patients in dominant model (p=0.016). Further analyses using the datasets from The Cancer Genome Atlas (TCGA) revealed that lower MALAT1 mRNA levels were associated with the advanced stage, and lymph node metastasis in LADC patients. In conclusion, our results showed that MALAT1 rs3200401 polymorphisms dramatically raised the probability of LUAD development.

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“…Numerous cellular and carcinogenesis processes are mediated by lncRNAs, including transcriptional regulators, tumorigenesis, cell migration, and invasion (Beermann et al, 2016) (Yangjun Wu et al, 2019) (Loganathan & Doss C, 2023). According to the lncRNA diseases database, Seventeen long non-coding including BCAR4, MALAT1, PVT1 and GAS5, have been revealed to have key roles in the tumor biology of breast cancer and several additional diseases including breast cancer, cardiovascular disease, and recurrent miscarriages (G. Chen et al, 2013) (Bao et al, 2019)(S. Li et al, 2023)(R. Peng et al, 2018) )(L. Cao et al, 2022. Modern genomic techniques have proven that lncRNA SNPs (single-nucleotide polymorphisms) are related to a variety of disorders, particularly malignancies, cardiometabolic disorders, and Alzheimer's condition.…”

Section: Functional Identification Of Long Non-coding Rnasmentioning

confidence: 99%

“…(Dechamethakun & Muramatsu, 2017)(Y. Tian et al, 2022). The impact of SNPs on operational lncRNAs is attracting considerable attention because of the possibility of influencing the risks of carcinomas, particularly breast cancer.…”

Section: Functional Identification Of Long Non-coding Rnasmentioning

confidence: 99%

Correlation Between Long non-coding RNA SOX2OT rs9839776 C>T Polymorphism and Unexplained Recurrent Miscarriages

Abd Ellatif,

Agwa,

Ashaat

et al. 2024

Egyptian Academic Journal of Biological Sciences. C, Physiology

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Recurrent miscarriage (RM) is a severe pregnancy complication that results in the loss of two or more spontaneous pregnancies. RM has several complex reasons. Advances in genetics, immunology, and cell biology have strongly connected non-coding RNAs (ncRNAs) to recurrent miscarriages. NcRNAs regulate placental trophoblast cell processes, which affect trophoblast development, migration, and invagination; they also have a role in breast and ovarian cancer. As a result, their abnormal expression may contribute to the progression of RM. Several investigations have found a connection between RM and genetic polymorphisms that regulate cell migration. Variations in the long non-coding RNA (lncRNA) SOX2OT gene have been associated with a variety of cancer-related illnesses, particularly colorectal cancer, breast cancer, and cancer of the digestive tract. According to a recent study, the long non-coding SOX2OT rs9839776 CT raises the risk of RM. In this review, we explain the existing evidence supporting a relationship between the LncRNA SOX2OT rs9839776 polymorphisms and recurrent miscarriages.

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Associations of MALAT1 and its functional single nucleotide polymorphisms with cancer

Cited by 12 publications

References 35 publications

Angio-Long Noncoding RNA MALAT1 (rs3200401) and MIAT (rs1061540) Gene Variants in Ovarian Cancer

Angio-Long Noncoding RNA MALAT1 (rs3200401) and MIAT (rs1061540) Gene Variants in Ovarian Cancer

Evaluation of the clinical significance of long non-coding RNA MALAT1 genetic variants in human lung adenocarcinoma

Correlation Between Long non-coding RNA SOX2OT rs9839776 C>T Polymorphism and Unexplained Recurrent Miscarriages

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