Associations of maternal ambient temperature exposures during pregnancy with the placental weight, volume and PFR: A birth cohort study in Guangzhou, China

Wang, Jiaqi; Liu, Xin; Dong, Moran; Sun, Xiangrong; Xiao, Jianpeng; Zeng, Weilin; Hu, Jianxiong; Li, Xing; Guo, Lingchuan; Rong, Zuhua; He, Guanhao; Sun, Jiufeng; Dan, Ning; Chen, Dengzhou; Zhang, Yonghui; Zhang, Bo; Ma, Wenjun

doi:10.1016/j.envint.2020.105682

Cited by 38 publications

(21 citation statements)

References 53 publications

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“…Prior experimental studies have shown an association between exposure to ambient temperature stress during pregnancy and weight loss and placental volume. Studies in Germany and Sweden (Wolf and Armstrong 2012), China (Wang et al 2020), and Sudan (Bruckner et al 2014) did not show a clear relationship between thermal stresses and adverse pregnancy outcomes. We investigated that extremely high and low temperatures were associated with decreases placental weight and diameter in pregnant mice.…”

Section: Discussionmentioning

confidence: 89%

Exposure to suboptimal ambient temperature during specific gestational periods and adverse outcomes in mice

Mayvaneh

Entezari

Sadeghifar

et al. 2020

Environ Sci Pollut Res

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Exposure to suboptimal ambient temperature during pregnancy has been reported as a potential teratogen of fetal development. However, limited animal evidence is available regarding the impact of extreme temperatures on maternal pregnancy and the subsequent adverse pregnancy outcomes. Our objective in this study is to investigate the relationship between temperature and maternal stress during pregnancy in mice. This study used the Naval Medical Research Institute (NMRI) mice during the second and third pregnant weeks with the gestational day (GD) (GD 6.5-14.5 and GD 14.5-17.5). Mice were exposed to suboptimal ambient temperature (1°C, 5°C, 10°C, 15°C, 40°C, 42°C, 44°C, 46°C, and 48°C for the experimental group and 23°C for the control group) 1 h per day, 7 days a weekin each trimester. Measurements of placental development (placental weight [PW] and placental diameter [PD]) and fetal growth (fetal weight [FW] and crown-to-rump length [CRL]) between experimental and control groups were compared using analysis of variance (ANOVA). Data on the occurrence of preterm birth (PTB) and abnormalities were also collected. The results showed that exposure to both cold and heat stress in the second and third weeks of pregnancy caused significant decreases in measurements of placental development (PW and PD) and fetal growth (FW and CRL). For all temperature exposures, 15°C was identified as the optimal temperature in the development of the embryo. Most PTB occurrences were observed in high-temperature stress groups, with the highest PTB number seen in the exposure group at 48°C, whereas PTB occurred only at 1°C among cold stress groups. In the selected exposure experiments, an approximate Ushaped relation was observed between temperature and number of abnormality occurrence. The highest percentage of these anomalies occurred at temperatures of 1°C and 48°C, while no abnormalities were observed at 15°C and in the control group. Our findings strengthened the evidence that exposure to suboptimal ambient temperatures may trigger adverse pregnancy outcomes and worsen embryo and fetal development in mice.

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Section: Discussionmentioning

confidence: 89%

Exposure to suboptimal ambient temperature during specific gestational periods and adverse outcomes in mice

Mayvaneh

Entezari

Sadeghifar

et al. 2020

Environ Sci Pollut Res

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“…All the participants met the inclusion criteria: (1) gestational weeks from 1 to 13; (2) aged 18-50 years; and (3) no comorbidity with the following diseases: hyperthyroidism, heart disease, chronic kidney disease, tuberculosis, and psychiatric disease. Detailed information has been presented elsewhere (30)(31)(32)(33)(34)(35). In this study, we recruited women with singleton pregnancies and without occupational exposure to Tl as study participants.…”

Section: Study Populationmentioning

confidence: 99%

The Mediating Role of Placental Weight Change in the Association Between Prenatal Exposure to Thallium and Birth Weight: A Prospective Birth Cohort Study

Zhou

Sun

Wang

et al. 2021

Front. Public Health

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Background: Previous studies have demonstrated the embryotoxicity and fetotoxicity of thallium (Tl). However, the effects of prenatal exposure to Tl on birth weight and placental weight and the mediating role of placental weight in the association of Tl with birth weight remain unclear.Methods: We recruited 2,748 participants from the ongoing Prenatal Environment and Offspring Health Cohort (PEOH Cohort) study, which was initiated in 2016 in Guangzhou, China. The Tl concentrations in maternal urine samples collected during the first and third trimester were determined by inductively coupled plasma mass spectrometry. Birth weight and placental weight were extracted from maternal medical records.Results: Pregnant women exposed to the highest tertile of Tl in the first trimester (β = −42.7 g, 95% CI: −82.3, −3.1 g) and third trimester (β = −50.6 g, 95% CI: −99.0, −2.3 g) had babies with lower birth weights than those exposed to the lowest tertile. We also found significant negative associations of exposure to Tl concentrations in the first and third trimester with placental weight. Mediation analyses showed that 50.3% (95% CI: 15.9, 79.2%) and 33.5% (95% CI: 1.3, 80.3%) of the effects of Tl exposure in the first and third trimester on birth weight were mediated by decreased placental weight.Conclusion: Our results suggest that prenatal exposure to Tl is negatively associated with birth weight and that this association may be mediated by decreased placental weight.

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“…There is some evidence that heat stress could cause a greater degree of hypoxemia in immature placental tissue, triggering the expression of vascular endothelial growth factor (VEGF) as a response. This activation can promote branching angiogenesis, reversing the placental hypoxia status, 35 , 36 and improving the growth of the fetus. Furthermore, infants whose mothers were exposed to peak sunshine during their first trimester were born significantly heavier than their counterparts with such exposure.…”

Section: Discussionmentioning

confidence: 99%

Association between maximum temperature and PM2.5 with pregnancy outcomes in Lima, Peru

Tapia

Vasquez-Apestegui

Alcantara-Zapata

et al. 2021

Environmental Epidemiology

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Background: We have previously documented an inverse relationship between PM 2.5 in Lima, Peru, and reproductive outcomes. Here, we investigate the effect of temperature on birth weight, birth weight-Z-score adjusted for gestational age, low birth weight, and preterm birth. We also explore interactions between PM 2.5 and temperature. Methods: We studied 123,034 singleton births in three public hospitals of Lima with temperature and PM 2.5 during gestation between 2012 and 2016. We used linear, logistic, and Cox regression to estimate associations between temperature during gestation and birth outcomes and explored possible modification of the temperature effect by PM 2.5 . Results: Exposure to maximum temperature in the last trimester was inversely associated with both birth weight [β: −23.7; 95% confidence interval [CI]: −28.0, −19.5] and z-score weight-for-gestational-age (β: −0.024; 95% CI: −0.029, −0.020) with an interquartile range of 5.32 °C. There was also an increased risk of preterm birth with higher temperature (interquartile range) in the first trimester (hazard ratio: 1.04; 95% CI: 1.001, 1.070). The effect of temperature on birthweight was primarily seen at higher PM 2.5 levels. There were no statistically significant associations between temperature exposure with low birth weight. Conclusions: Exposition to maximum temperature was associated with lower birth weight and z-score weight-for-gestational-age and higher risk of preterm birth, in accordance with much of the literature. The effects on birth weight were seen only in the third trimester.

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Associations of maternal ambient temperature exposures during pregnancy with the placental weight, volume and PFR: A birth cohort study in Guangzhou, China

Cited by 38 publications

References 53 publications

Exposure to suboptimal ambient temperature during specific gestational periods and adverse outcomes in mice

Exposure to suboptimal ambient temperature during specific gestational periods and adverse outcomes in mice

The Mediating Role of Placental Weight Change in the Association Between Prenatal Exposure to Thallium and Birth Weight: A Prospective Birth Cohort Study

Association between maximum temperature and PM2.5 with pregnancy outcomes in Lima, Peru

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