Associations of Maternal Polyunsaturated Fatty Acids With Telomere Length in the Cord Blood and Placenta in Chinese Population

Liu, Xuanyi; Shi, Qiaoyu; Fan, Xiuqin; Chen, Hang; Chen, Na; Zhao, Yongfei; Qi, Kemin

doi:10.3389/fnut.2021.779306

Cited by 6 publications

(5 citation statements)

References 66 publications

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“…Shortened TL among fetuses exposed to maternal high fat consumption during pregnancy, after accounting for the effects of potential covariates, was recorded in the Salihu et al study [96]. However, according to the Liu et al study, concentrations of total n3-PUFAs and docosahexaenoic acid (DHA) in maternal erythrocytes, are closely correlated to infant TL and the telomerase reverse transcriptase (TERT) promoter methylation [94]. Contradictory evidence for maternal PUFA status and its relation to offspring TL was recorded in the cohort study by Yeates et al [95].…”

Section: Maternal Nutrition and Placental And Newborn Telomeresmentioning

confidence: 99%

See 1 more Smart Citation

Preterm Birth and Its Association with Maternal Diet, and Placental and Neonatal Telomere Length

Lis,

Lamnisos,

Bograkou-Tzanetakou

et al. 2023

Nutrients

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Preterm birth (PTB), a multi-causal syndrome, is one of the global epidemics. Maternal nutrition, but also neonatal and placental telomere length (TL), are among the factors affecting PTB risk. However, the exact relationship between these factors and the PTB outcome, remains obscure. The aim of this review was to investigate the association between PTB, maternal nutrition, and placental-infant TL. Observational studies were sought with the keywords: maternal nutrition, placental TL, newborn, TL, and PTB. No studies were found that included all of the keywords simultaneously, and thus, the keywords were searched in dyads, to reach assumptive conclusions. The findings show that maternal nutrition affects PTB risk, through its influence on maternal TL. On the other hand, maternal TL independently affects PTB risk, and at the same time PTB is a major determinant of offspring TL regulation. The strength of the associations, and the extent of the influence from covariates, remains to be elucidated in future research. Furthermore, the question of whether maternal TL is simply a biomarker of maternal nutritional status and PTB risk, or a causative factor of PTB, to date, remains to be answered.

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Section: Maternal Nutrition and Placental And Newborn Telomeresmentioning

confidence: 99%

“…In terms of dietary lipids, one study examined the effect of n3 intake on umbilical cord, placenta, and infant TL. Maintaining higher levels of maternal n3 polyunsaturated fatty acids (PUFAs) during pregnancy may help maintain TL in the offspring, which is beneficial to long-term offspring health [94].…”

mentioning

confidence: 99%

Preterm Birth and Its Association with Maternal Diet, and Placental and Neonatal Telomere Length

Lis,

Lamnisos,

Bograkou-Tzanetakou

et al. 2023

Nutrients

View full text Add to dashboard Cite

show abstract

“…It has also been recently reported the effect of maternal intake of n-3 PUFAs during pregnancy influences the offspring DNA methylation [ 197 ]. Also, it has been recently shown that maternal n-3 PUFAs supplementations are closely correlated to infant telomere length [ 198 ]. However, the long-term effect of maternal intake of n-3 PUFAs in reducing future risk of metabolic and cardiovascular diseases in the offspring is unknown.…”

Section: Micronutrientsmentioning

confidence: 99%

Dietary supplements and vascular function in hypertensive disorders of pregnancy

Man

Zhou

Xia

et al. 2023

Pflugers Arch - Eur J Physiol

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Hypertensive disorders of pregnancy are complications that can lead to maternal and infant mortality and morbidity. Hypertensive disorders of pregnancy are generally defined as hypertension and may be accompanied by other end organ damages including proteinuria, maternal organ disturbances including renal insufficiency, neurological complications, thrombocytopenia, impaired liver function, or uteroplacental dysfunction such as fetal growth restriction and stillbirth. Although the causes of these hypertensive disorders of pregnancy are multifactorial and elusive, they seem to share some common vascular-related mechanisms, including diseased spiral arteries, placental ischemia, and endothelial dysfunction. Recently, preeclampsia is being considered as a vascular disorder. Unfortunately, due to the complex etiology of preeclampsia and safety concerns on drug usage during pregnancy, there is still no effective pharmacological treatments available for preeclampsia yet. An emerging area of interest in this research field is the potential beneficial effects of dietary intervention on reducing the risk of preeclampsia. Recent studies have been focused on the association between deficiencies or excesses of some nutrients and complications during pregnancy, fetal growth and development, and later risk of cardiovascular and metabolic diseases in the offspring. In this review, we discuss the involvement of placental vascular dysfunction in preeclampsia. We summarize the current understanding of the association between abnormal placentation and preeclampsia in a vascular perspective. Finally, we evaluate several studied dietary supplementations to prevent and reduce the risk of preeclampsia, targeting placental vascular development and function, leading to improved pregnancy and postnatal outcomes.

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“…In terms of dietary lipids, one study examined the effect of omega-3 intake and their effect on umbilical cord, placenta and infant TL. Keeping higher levels of maternal n-3 polyunsaturated fatty acids (PUFAs) during pregnancy, may help maintain TL in the offspring, which is beneficial to longterm offspring health [94].…”

Section: Maternal Nutrition Placental and Newborn Telomeresmentioning

confidence: 99%

“…Shortened TL among fetuses exposed to maternal high fat consumption during pregnancy, after accounting for the effects of potential covariates, was recorded in the Salihu, et al [96], but with no association recorded for a high carbohydrate diet. However, according to Liu et al study concentrations of total n3-PUFAs and docosahexaenoic acid (DHA) in maternal erythrocytes, are closely correlated to infant TL and the telomerase reverse transcriptase (TERT) promoter methylation [94]. Maternal n-3 PUFAs (a-linolenic, eicosapentaenoic and docosahexaenoic acids) in cord blood and the placenta correlated to infant TL and TERT promoter methylation, differently in cord blood and the placenta.…”

Section: Maternal Nutrition Placental and Newborn Telomeresmentioning

confidence: 99%

Preterm Birth and Its Association with Maternal Diet, and Placental and Neonatal Telomere Length

Lis,

Lamnisos,

Bograkou - Tzanetakou

et al. 2023

Preprint

View full text Add to dashboard Cite

Preterm birth (PTB), a multi-causal syndrome, is one of the global epidemics. Maternal nutrition, but also neonatal and placental telomere length (TL), are among the factors affecting PTB risk. However, the exact relationship between these factors and the PTB outcome, remains obscure. The aim of this review, was to investigate the association between PTB, maternal nutrition and placental-infant TL. Observational studies were sought, with the keywords: maternal nutrition, placenta TL, newborn, TL, and PTB. No study was found that included all keywords simultaneously, and thus, the keywords, were searched in dyads, to reach assumptive conclusions. The findings show that maternal nutrition affects PTB risk, through its influence on maternal TL. On the other hand, maternal TL independently affects PTB risk, and at the same time PTB is a major determinant of offspring TL regulation. The strength of the associations and the extent of the influence from covariates, remains to be elucidated in future research. Furthermore, the question of whether maternal TL, is simply a biomarker of maternal nutritional status and PTB risk, or a causative factor of PTB, to date, remains to be answered.

show abstract

Associations of Maternal Polyunsaturated Fatty Acids With Telomere Length in the Cord Blood and Placenta in Chinese Population

Cited by 6 publications

References 66 publications

Preterm Birth and Its Association with Maternal Diet, and Placental and Neonatal Telomere Length

Preterm Birth and Its Association with Maternal Diet, and Placental and Neonatal Telomere Length

Dietary supplements and vascular function in hypertensive disorders of pregnancy

Preterm Birth and Its Association with Maternal Diet, and Placental and Neonatal Telomere Length

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