Associations of micronutrient dietary patterns with sarcopenia among US adults: a population-based study

Abstract

BackgroundCurrent epidemiological evidence points to an association between micronutrient (MN) intake and sarcopenia, but studies have focused on single MN, and no combined effects on MNs have been reported. The aim of this study was to investigate the relationship between different MN intake patterns and sarcopenia and skeletal muscle mass.MethodsWe performed a population-based cross-sectional study, with a total of 5,256 U.S. adults aged 20–59 years, and we collected total daily MN intake and appendicular skeletal muscle mass measured by Dual-Energy X-ray Absorptiometry (DXA). Principal component analysis (PCA) was used to obtain nutrient patterns and principal component scores based on the intake of 14 MNs, and logistic regression analysis was used to assess the effects of single MN and MN intake patterns on sarcopenia and muscle mass.ResultsWe defined three MN intake patterns by PCA: (1) adherence to VitB-mineral, high intake of vitamin B and minerals; (2) adherence to VitAD-Ca-VB12, high intake of vitamin A, vitamin D, calcium and vitamin B12; and (3) adherence to Antioxidant Vit, high intake of antioxidant vitamins A, C, E, and K. These three nutrient patterns explained 73.26% of the variance of the population. A negative association was observed between most single MN intakes and sarcopenia, and after adjusting for confounders, adherence to the highest tertile of the three nutrient patterns was associated with a lower risk of sarcopenia and relatively higher skeletal muscle mass compared to the lowest adherence. In subgroup analysis, MN intake patterns were significantly correlated with sarcopenia in middle-aged females.ConclusionNutritional patterns based on MN intake were significantly related to sarcopenia, indicating that MNs interact with each other while exerting their individual functions, and that MN dietary patterns may provide promising strategies for preventing the loss of muscle mass, with further prospective studies warranted in the future.

Synergistic Effects of Nutrients on Musculoskeletal Health in Gerontology: Understanding the Combined Impact of Macronutrients and Micronutrients

“…Studies by Feskanich et al and Dzik et al highlight the efficacy of calcium and VD in reducing bone loss and improving muscle strength and function, respectively [ 4 , 26 , 27 ]. VD may enhance the beneficial effects of Ca on muscle by improving its bioavailability and potentiating its anabolic effects [ 28 ]. Our study extends this understanding by highlighting the importance of selenium, potassium, and magnesium.…”

Micronutrient Patterns and Low Intake of Vitamin A, Vitamin D, Folate, Magnesium, and Potassium Among Prediabetes and Type 2 Diabetes Patients

“…Assessing micronutrient intake against recommended dietary intakes (RDI) and obtaining information on micronutrient patterns contribute to a more holistic picture of micronutrient intake. Few studies have assessed the association between micronutrient patterns and conditions such as sarcopenia [11] or cognitive function [10]. However, research specifically examining the relationship between micronutrient patterns and diabetes or prediabetes remains limited.…”