Associations of mixed urinary metals exposure with metabolic syndrome in the US adult population

Zha, Bowen; liu, Yuqi; Xu, Huanchang

doi:10.1016/j.chemosphere.2023.140330

Cited by 4 publications

(2 citation statements)

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“…However, limited research has investigated the effects of Cs exposure on human lipid profiles, and most have concentrated on the association between exposure to Cs and metabolic syndrome and its diagnostic factors. Two US population-based studies consistently indicated that Cs exposure was negatively related to metabolic syndrome [ 45 , 46 ]. When Zha et al further analyzed the effect of Cs exposure on its components, Cs had the largest weight in TG in the negative direction of the WQS model [ 46 ].…”

Section: Discussionmentioning

confidence: 99%

“…Two US population-based studies consistently indicated that Cs exposure was negatively related to metabolic syndrome [ 45 , 46 ]. When Zha et al further analyzed the effect of Cs exposure on its components, Cs had the largest weight in TG in the negative direction of the WQS model [ 46 ]. We hold that since RC is TG-rich lipoprotein cholesterol, a decrease in TG also leads to a decrease in RC.…”

Section: Discussionmentioning

confidence: 99%

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Associations of Urinary Heavy Metal Mixtures with High Remnant Cholesterol among US Adults: Evidence from the National Health and Nutrition Examination Survey (1998–2018)

Li,

Cheng,

Yang

et al. 2024

Toxics

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The main objective of our study is to explore the associations between combined exposure to urinary heavy metals and high remnant cholesterol (HRC), a known cardiovascular risk factor. Utilizing data from the National Health and Nutrition Examination Survey (NHANES) from 1999 to 2018, we conducted a cross-sectional analysis of 5690 participants, assessing urinary concentrations of ten heavy metals. Ten heavy metals in urine were measured by inductively coupled plasma mass spectrometry (ICP-MS). Fasting residual cholesterol ≥0.8 mmol/L was defined as HRC (using blood samples). Statistical analyses included weighted multivariable logistic regression, weighted quantile sum (WQS) regression, quantile g-computation (qgcomp), and Bayesian kernel machine regression (BKMR) to evaluate the associations of heavy metal exposure with HRC. Stratified analyses based on individual characteristics were also conducted. Multivariable logistic regression found that the four metals (OR Q4 vs. Q1: 1.33, 95% CI: 1.01–1.75 for barium (Ba); OR Q4 vs. Q1: 1.50, 95% CI: 1.16–1.94 for cadmium (Cd); OR Q4 vs. Q1: 1.52, 95% CI: 1.15–2.01 for mercury (Hg); OR Q4 vs. Q1: 1.35, 95% CI: 1.06–1.73 for lead (Pb)) were positively correlated with the elevated risk of HRC after adjusting for covariates. In addition, all three mixed models, including WQS (OR: 1.25; 95% CI: 1.07–1.46), qgcomp (OR: 1.17; 95% CI: 1.03–1.34), and BKMR, consistently showed a significant positive correlation between co-exposure to heavy metal mixtures and HRC, with Ba and Cd being the main contributors within the mixture. These associations were more pronounced in younger adults (20 to 59 years), males, and those with a higher body mass index status (≥25 kg/m2). Our findings reveal a significant relationship between exposure to the mixture of heavy metals and HRC among US adults, with Ba and Cd being the major contributors to the mixture’s overall effect. Public health efforts aimed at reducing heavy metal exposure can help prevent HRC and, in turn, cardiovascular disease.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Associations of Urinary Heavy Metal Mixtures with High Remnant Cholesterol among US Adults: Evidence from the National Health and Nutrition Examination Survey (1998–2018)

Li,

Cheng,

Yang

et al. 2024

Toxics

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Terpene mixtures and metabolic syndrome in the US general population: exploring the mediating role of insulin resistance

Wang,

Zhang,

Zhao

et al. 2024

BMC Public Health

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Association between blood heavy metals and fecal incontinence in American adults: A population-based study

Li,

Peng,

Zhang

et al. 2024

BMC Public Health

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Background Previous studies have revealed the impact of heavy metals (HMs) on gut microbiota and intestinal structure. However, the relationship between HMs and fecal incontinence (FI) remains unclear. Therefore, this study aims to evaluate the association between blood HMs exposure and FI. Methods Data for this study were obtained from the 2005–2010 cycles of National Health and Nutrition Examination Survey (NHANES). Information regarding FI was retrieved from the Bowel Health Questionnaire, while data on HMs were collected through laboratory examinations. Weighted logistic regression, two-indices weighted quantile sum (2iWQS), quantile g-computation (qgcomp), and restricted cubic splines (RCS) were employed to explore the relationships between blood levels of cadmium (Cd), lead (Pb), and mercury (Hg) and FI. Additionally, Subgroup analyses were conducted to discern specific associations within distinct populations. Results A total of 12,142 participants aged 20 years and above were included in this study. Weighted logistic regression indicated a positive association between Cd (Crude model: OR = 1.21, 95% CI: 1.09–1.35, p < 0.001) and Pb (Crude model: OR = 1.01, 95% CI: 1.01–1.02, p < 0.001) with FI. After adjusting for all covariates, the positive associations remained significant for Cd (Model 2: Q1 vs. Q3, OR = 1.38, 95% CI: 1.04–1.83, p = 0.026) and Pb (Model 2: OR = 1.01, 95% CI: 1.00–1.01, p = 0.004). The 2iWQS regression analysis demonstrated a positive correlation between the mixture of three blood HMs and FI (OR = 1.18, 95% CI: 1.05–1.32, p = 0.005), with Cd having the highest weight among the metals (0.76). The qgcomp analysis confirmed this finding (OR = 1.12, 95% CI: 1.01–1.26, p = 0.036; weight = 0.72). Subgroup analysis revealed that the positive association between Cd and FI was more pronounced among males; Mexican Americans; those with a poverty income ratio (PIR) > 2; individuals with college or above education; overweight participants; never-smokers; heavy drinkers; those with hypertension; and non-diabetes individuals. Conversely, the association between Pb and FI was stronger among participants aged 40–60, overweight participants, and never-smokers. Conclusion Exposure to blood HMs, particularly Cd, is associated with FI in American adults. Future research should focus on elucidating the causal relationships and underlying mechanisms. Supplementary Information The online version contains supplementary material available at 10.1186/s12889-024-20958-z.

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Associations of mixed urinary metals exposure with metabolic syndrome in the US adult population

Cited by 4 publications

References 41 publications

Associations of Urinary Heavy Metal Mixtures with High Remnant Cholesterol among US Adults: Evidence from the National Health and Nutrition Examination Survey (1998–2018)

Associations of Urinary Heavy Metal Mixtures with High Remnant Cholesterol among US Adults: Evidence from the National Health and Nutrition Examination Survey (1998–2018)

Terpene mixtures and metabolic syndrome in the US general population: exploring the mediating role of insulin resistance

Association between blood heavy metals and fecal incontinence in American adults: A population-based study

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