Associations of neutrophil-percentage-to-albumin ratio level with all-cause mortality and cardiovascular disease-cause mortality among patients with hypertension: evidence from NHANES 1999–2010

Background Inflammation is crucial in the development of depression. This study aims to examine the potential association between the Neutrophil-Percentage-to-Albumin Ratio(NPAR) and depression symptoms. Methods This study adopted a cross-sectional design, involving patients with depression symptoms and those without depression symptoms with comprehensive NPAR data originated from the National Health and Nutrition Examination Survey(NHANES) spanning 2011 to 2018. The research utilized weighted multivariate logistic regression models and multivariate linear regression to investigate the linear relationship between NPAR levels and depression symptoms and its severity scores. The characterization of nonlinear relationships was accomplished by employing fitted smoothing curves. Furthermore, subgroup analyses and interaction assessments were conducted to offer additional insights. Results This study involved a total of 10,829 participants, and the prevalence of depression among them was found to be 15.08%. The multiple logistic regression analysis revealed a statistically significant positive association between the continuum of NPAR and depression symptoms[OR:1.03, 95% CI: (1.00, 1.05)], as well as depression severity scores[β: 0.08, 95% CI: (0.04,0.11)]. Stratifying NPAR into quartiles, we found that higher NPAR associated with increased odds of depression symptoms. Furthermore, in subgroup analysis, there were no significant differences in the relationship between NPAR levels and depression symptoms or its severity scores within populations with or without diabetes and cardiovascular diseases. Additionally, the use of a two-stage linear regression model uncovered a non-linear relationship between NPAR and depression symptoms. Conclusions Our research indicates that NPAR levels were associated with depression symptoms. To corroborate our findings, larger prospective studies are warranted to elucidate nonlinear associations in greater detail. Supplementary Information The online version contains supplementary material available at 10.1186/s12888-024-06178-0.

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Association of neutrophil percentage-to-albumin ratio with all-cause and respiratory disease-related mortality in US adults with asthma: results from NHANES 1999-2018

Wang,

Su,

et al. 2024

Preprint

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Background: Systemic inflammation and immune dysregulation may be associated with asthma onset and progression. Neutrophil percentage-to-albumin ratio (NPAR) is a novel marker of systemic inflammation. We aimed to investigate the association of NPAR with all-cause and respiratory disease-related mortality in adults with asthma through NHANES 1999-2018. Methods:NPAR was calculated by neutrophil percentage (% of total white blood cell count) × 100/serum albumin (g/dl). Asthma was diagnosed by standardized questionnaire. Mortality was obtained by prospective matching with the National Death Index. Multivariate Cox proportional hazards regression analysis was used to explore these associations. Results:A total of 5042 adults with asthma were included. After a median follow-up duration of 104 months, 697 participants died, of which 101 were respiratory disease-related deaths. In fully adjusted models, NPAR was significantly and positively associated with both all-cause and respiratory disease-related mortality (hazard ratios [HR] of 1.126 and 1.194, respectively, both p < 0.05). Compared to Q1, NPAR at Q4 was associated with significantly increased all-cause and respiratory disease-related mortality (all-cause: HR 2.112, p < 0.0001; respiratory disease-related: HR 2.595, p = 0.013). NPAR was nonlinearly associated with all-cause mortality, with an inflection point of 13.76. This association was significant only after the inflection point. The effect of NPAR on all-cause mortality was more pronounced in those <60 years of age. Conclusions:Higher NPAR was associated with increased all-cause and respiratory disease mortality in US adults with asthma. Further exploration of the prognostic potential and underlying mechanisms of NPAR is needed. Clinical trial number Not applicable.

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Associations of neutrophil-percentage-to-albumin ratio level with all-cause mortality and cardiovascular disease-cause mortality among patients with hypertension: evidence from NHANES 1999–2010

Cited by 4 publications

References 29 publications

Elevated neutrophil-percentage-to-albumin ratio predicts increased all-cause and cardiovascular mortality in hypertensive patients: Evidence from NHANES 1999–2018

Elevated neutrophil-percentage-to-albumin ratio predicts increased all-cause and cardiovascular mortality in hypertensive patients: Evidence from NHANES 1999–2018

Association of Neutrophil-Percentage-To-Albumin Ratio(NPAR) with depression symptoms in U.S. adults: a NHANES study from 2011 to 2018

Association of neutrophil percentage-to-albumin ratio with all-cause and respiratory disease-related mortality in US adults with asthma: results from NHANES 1999-2018

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