Associations of objectively measured sedentary behaviour and physical activity with markers of cardiometabolic health

Abstract

Aims/hypothesis The study aimed to examine the associations between objectively measured sedentary time, breaks in sedentary time, moderate-to-vigorous physical activity (MVPA) and total physical activity with markers of cardiometabolic health in a population with known risk factors for type 2 diabetes mellitus. Methods This study reports data from two ongoing diabetes prevention programmes. Participants with known risk factors were recruited from primary care practices located within the East Midlands, UK, over the period [2010][2011]

Objectively Measured Sedentary Time and Cardiovascular Risk Factor Control in US Hispanics/Latinos With Diabetes Mellitus: Results From the Hispanic Community Health Study/Study of Latinos (HCHS/SOL)

“…This is consistent with previous observations that sedentary behavior was strongly associated with several glycemic traits,30, 31, 32 though its association with HbA 1c levels has not been well studied. A previous cross‐sectional study reported that objectively measured sedentary behavior showed a trend for association with elevated HbA 1c in 394 newly diagnosed adults with diabetes mellitus,10 whereas a recent study found that there were no cross‐sectional or 5‐year longitudinal associations between objectively measured sedentary time and HbA 1c in young adults 33.…”

“…This is consistent with the potential mechanism that reduced skeletal muscle contractions from prolonged sedentary behavior may depress uptake of plasma triglycerides and triglycerides‐derived fatty acid into skeletal muscle through suppression of lipoprotein lipase activity 36, 37. In addition, our findings have some coherence with previous research reporting deleterious associations between sedentary behavior and HDL‐c,10, 22, 32 though we did not observe a significant association between sedentary behavior and reaching HDL‐c control goal in people with diabetes mellitus.…”

“…Further analysis confirmed the strong association between objectively measured sedentary behavior and triglyceride levels, which was previously observed in individuals both with and without diabetes mellitus 10, 22, 30, 32, 34, 35. This is consistent with the potential mechanism that reduced skeletal muscle contractions from prolonged sedentary behavior may depress uptake of plasma triglycerides and triglycerides‐derived fatty acid into skeletal muscle through suppression of lipoprotein lipase activity 36, 37.…”

El sedentarismo se asocia a un incremento de factores de riesgo cardiovascular y metabólicos independiente de los niveles de actividad física

“…Los resultados encontrados en la presente investigación concuerdan con numerosos estudios que han sido resumidos en revisiones sistemáticas y metaanálisis recientes [20][21][22] . Brocklebank y cols., en una revisión sistemática, identificaron 28 estudios que reportaron asociación entre sedentarismo y factores de riesgo cardiovascular, donde los mayores efectos nocivos del sedentarismo fueron observados en marcadores de diabetes mellitus, incluyendo, glicemia, insulina y marcadores de resistencia a la insulina 20 .…”

Managing Sedentary Behavior to Reduce the Risk of Diabetes and Cardiovascular Disease

“…In participants at greater risk of developing T2D, higher sedentary time has been shown to be predictive of elevated 2-h glucose, among other cardiometabolic risk factors, while breaks in sitting time are associated with lower 2-h glucose [53]. Detrimental associations of sedentary time on fasting insulin were recently shown in 528 patients with newly diagnosed T2D using objective sedentary measurement [54]; however, their 6 month follow-up analysis showed no beneficial changes with breaks in sedentary time.…”