Associations of oxytocin and vasopressin plasma levels with neurocognitive, social cognitive and meta cognitive function in schizophrenia

Aydın, Orkun; Lysaker, Paul H.; Balıkçı, Kuzeymen; Ünal-Aydin, Pınar; Esen-Danacı, Ayşen

doi:10.1016/j.psychres.2018.03.048

Cited by 52 publications

(36 citation statements)

References 48 publications

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“…In contrast, other studies have shown that blood OXT levels are lower in patients with schizophrenia [9,49]. Some studies have shown no significant decrease in levels of AVP in schizophrenia patients compared to controls [50,51]. In our study, no statistically significant difference was found between serum OXT, AVP and ANP levels of schizophrenic patients and healthy controls.…”

Section: Clinical Symptoms Of Schizophreniacontrasting

confidence: 94%

The relationship between oxytocin, vasopressin and atrial natriuretic peptide levels and cognitive functions in patients with schizophrenia

Pek¹,

Yazıcı

Güzel

et al. 2019

Psychiatry and Clinical Psychopharmacology

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Objective: The aim of this study was to investigate the relationship between oxytocin (OXT), vasopressin (AVP) and atrial natriuretic peptide (ANP) levels and cognitive functions in schzophrenia as well as to compare the findings to those in healthy controls. Method: Patients with chronic schizophrenia and (n=63) healthy controls (n=60) were evaluated with the Rey Auditory Verbal Learning Test (VLT), the Trail Making Test A-B (TMT), the Stroop Test, the Wechsler Memory Scale-Visual Production Subscale (WMS-V) and the Facial Emotion Recognition Tests. Blood samples were analysed by using ELISA. In the data analysis, the percentage distributions of the variables were obtained, the centrality and prevalence measures (mean, standard deviation) were calculated for the continuous variables, and the dependent and independent variables were evaluated using the chisquare test, the Student's t-test, and the Pearson correlation test. High score variables were determined by principal component analysis. For comparisons between groups; MANOVA applied. Results: Serum OXT, AVP and ANP levels did not differ between the groups. In the healthy control group, subscales of the Stroop, WMS-V and TMT-B tests showed better scores and correlated with levels of OXT (p < .05). In the healthy controls, ANP levels and social cognition had a relationship with response times to happy facial expressions (p < .05). The correlations of OXT, AVP and ANP with the social and cognitive parameters were different between the control group and the schizophrenia group (p < .05). Conclusion: The different correlations in the healthy controls and schizophrenia group suggest deteriorations in the interactions and functions of hormones in patients and highlights the need for new investigations into different neurodegenerative illness samples.

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Section: Clinical Symptoms Of Schizophreniacontrasting

confidence: 94%

The relationship between oxytocin, vasopressin and atrial natriuretic peptide levels and cognitive functions in patients with schizophrenia

Pek¹,

Yazıcı

Güzel

et al. 2019

Psychiatry and Clinical Psychopharmacology

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“…Other studies have found metacognition predicted social functioning prospectively over a 5-month interval (Lysaker et al, 2011b) and that changes in metacognitive capacity were associated with improvements in social skills (Inchausti et al, 2017a). Support for a link between metacognition and social functioning can also be found in research suggesting that metacognitive deficits predict multiple psychological constructs and biological processes believed to be cornerstones of social functioning, including intrinsic motivation (Luther et al, 2016(Luther et al, , 2017, complexity of social schema (Lysaker et al, 2010b), anhedonia (Buck et al, 2014), aggression (de Jong et al, 2018), sense of social connection (Kukla, Lysaker, & Salyers, 2013), empathy (Bonfils, Lysaker, Minor, & Salyers, 2018;WeiMing, Yi, Lysaker, & Kai, 2015), and levels of oxytocin (Aydin, Lysaker, Balıkçı, Ü nal-Aydın, & Esen-Danacı, 2018).…”

Section: Introductionmentioning

confidence: 91%

Metacognitive deficits and social functioning in schizophrenia across symptom profiles: A latent class analysis

Gagen

Zalzala

Hochheiser

et al. 2019

Journal of Experimental Psychopathology

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Functional deficits are a hallmark of schizophrenia spectrum disorders, but much debate still exists over why and how they originate. One model suggests that disturbances in social functioning are a result of metacognitive deficits or a failure to integrate information to form more complex ideas of themselves and others. It is unclear if this social dysfunction is present across different symptom presentations. We examined the relationship of metacognition, symptoms, and social functioning among a sample of adults with schizophrenia spectrum disorders (N ¼ 334). A latent class analysis produced a four-class model. Groups were classified as follows: diffuse symptoms/moderately impaired social functioning (Class 1), positive and hostility symptoms/mildly impaired social functioning (Class 2), minimal symptoms/good social functioning (Class 3), and negative and cognitive symptoms/severely impaired social functioning (Class 4). Class 3 demonstrated better overall metacognitive capacity than both Classes 1 and 4 but did not differ significantly from Class 2. Classes 2 and 3 both demonstrated better interpersonal functioning than Classes 1 and 4. Together, these findings provide support for models of poor functioning that stem from fragmentation of an individual's experience, leading to diminished abilities to form meaningful connections with others. Additional interpretations, limitations, and research implications are discussed.

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“…However, in a recent study, an increase in plasma concentration of vasopressin in schizophrenic patients compared to controls was reported (Guzel et al, ). Also, in a recent study by Aydin and coworkers no difference in plasma vasopressin in schizophrenic patients was detected (Aydın, Lysaker, Balıkçı, Ünal‐Aydın, & Esen‐Danacı, ). The time of day when the blood samples were obtained was rarely given in above quoted studies.…”

Section: Discussionmentioning

confidence: 94%

Expression of vasopressin mRNA in the hypothalamus of individuals with a diagnosis of schizophrenia

et al. 2019

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Objective This study investigates the expression of mRNA encoding vasopressin in the hypothalamus of autopsy brains of individuals diagnosed with schizophrenia. Methods Ten brains of individuals with schizophrenia and 10 brains from individuals without any disease were examined during autopsy. The hypothalamic block was dissected and immersion fixed in paraformaldehyde, sucrose substituted, frozen, and cut into 20‐µm‐thick coronal cryostat sections. The sections were hybridized with an S‐35‐labeled DNA antisense oligo probe and after washing covered by an X‐ray film. The hybridization signals on the films were transferred to a computer and densitometrically quantified. Results The densitometry signals showed a statistically significant lower mRNA expression (53% decrease; p = 0.014) in the paraventricular nucleus of the individuals with schizophrenia compared to the controls. In the supraoptic nucleus, the decrease in the group with schizophrenia was 39% compared to the controls, but this decrease was not statistically significant (p = 0.194). Conclusions Our results show a low expression of mRNA encoding vasopressin in the paraventricular nucleus of the individuals with schizophrenia. We suggest that vasopressin is not directly involved in the pathogenesis of schizophrenia, but might influence schizophrenic symptoms via vasopressin receptors located in the social behavioral neural network in the forebrain.

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Associations of oxytocin and vasopressin plasma levels with neurocognitive, social cognitive and meta cognitive function in schizophrenia

Cited by 52 publications

References 48 publications

The relationship between oxytocin, vasopressin and atrial natriuretic peptide levels and cognitive functions in patients with schizophrenia

The relationship between oxytocin, vasopressin and atrial natriuretic peptide levels and cognitive functions in patients with schizophrenia

Metacognitive deficits and social functioning in schizophrenia across symptom profiles: A latent class analysis

Expression of vasopressin mRNA in the hypothalamus of individuals with a diagnosis of schizophrenia

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