Associations of paternal serum dioxin-like polychlorinated biphenyl concentrations with IVF success: A pilot study

Paul, Raiza; Romero, Alejandro; Moltó, Julia; García, Nuria Ortuño; Aizpurúa, Jon; Gómez‐Torres, María José

doi:10.1016/j.envres.2021.112248

Cited by 2 publications

(1 citation statement)

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“…A correlation between increasing serum PCB levels and lower concentration of serum testosterone in some American males was noticed [ 202 ]. Furthermore, significant associations between low environmental levels of serum dioxin-like PCBs in male partners of subfertile couples and pregnancy outcomes of in vitro fertilization, such as implantation, clinical pregnancy and live births were observed [ 203 ]. PCBs may have direct effects on spermatogenesis as they easily penetrate the blood–testis barrier [ 204 ], and their accumulation is also associated with testicular cancer [ 205 ].…”

Section: Effects Of Pcbs On Human Healthmentioning

confidence: 99%

Polychlorinated Biphenyls (PCBs) in the Environment: Occupational and Exposure Events, Effects on Human Health and Fertility

Montano

Pironti

Pinto

et al. 2022

Toxics

104

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In the last decade or so, polychlorinated biphenyls (PCBs) garnered renewed attention in the scientific community due to new evidence pointing at their continued presence in the environment and workplaces and the potential human risks related to their presence. PCBs move from the environment to humans through different routes; the dominant pathway is the ingestion of contaminated foods (fish, seafood and dairy products), followed by inhalation (both indoor and outdoor air), and, to a lesser extent, dust ingestion and dermal contact. Numerous studies reported the environmental and occupational exposure to these pollutants, deriving from building materials (flame-retardants, plasticizers, paints, caulking compounds, sealants, fluorescent light ballasts, etc.) and electrical equipment. The highest PCBs contaminations were detected in e-waste recycling sites, suggesting the need for the implementation of remediation strategies of such polluted areas to safeguard the health of workers and local populations. Furthermore, a significant correlation between PCB exposure and increased blood PCB concentrations was observed in people working in PCB-contaminated workplaces. Several epidemiological studies suggest that environmental and occupational exposure to high concentrations of PCBs is associated with different health outcomes, such as neuropsychological and neurobehavioral deficits, dementia, immune system dysfunctions, cardiovascular diseases and cancer. In addition, recent studies indicate that PCBs bioaccumulation can reduce fertility, with harmful effects on the reproductive system that can be passed to offspring. In the near future, further studies are needed to assess the real effects of PCBs exposure at low concentrations for prolonged exposure in workplaces and specific indoor environments.

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