Associations of perfluoroalkyl and polyfluoroalkyl substances with gestational hypertension and blood pressure during pregnancy: A cohort study

Yang, Lan; Ji, Honglei; Liang, Hong; Yuan, Wei; Song, Xiaoyan; Li, Xiufeng; Niu, Jinbo; Shi, Huijuan; Wen, Shi Wu; Miao, Maohua

doi:10.1016/j.envres.2022.114284

Cited by 15 publications

(8 citation statements)

References 58 publications

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“…Moreover, we also found that there was a positive trend between PFDoA and BP of the offspring with both multiple linear regression and BKMR. Only one cohort study has investigated the association between individual PFDoA levels in maternal serum and the risk of gestational hypertension, and demonstrated an inverse relationship, which is inconsistent with our results [ 44 ]. Thus, further studies with larger sample size, multiple regions and detailed evaluation of BP are in need.…”

Section: Discussioncontrasting

confidence: 99%

Perfluoroalkyl substances in umbilical cord blood and blood pressure in offspring: a prospective cohort study

Xu,

Du,

Wang

et al. 2023

Environ Health

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Background Humans are widely exposed to perfluoroalkyl substances (PFAS), which have been found to be associated with various adverse birth outcomes. As blood pressure (BP) is an important parameter reflecting cardiovascular health in early life, it is necessary to investigate the association of PFAS exposure during early lifetime and BP in childhood. Therefore, we investigated the potential association between PFAS levels in umbilical cord blood and BP of the offspring at 4 years of age in a prospective cohort study. Methods PFAS in umbilical cord blood samples after birth were measured with high-performance liquid chromatography/tandem mass spectrometry in the Shanghai Birth Cohort. BP was measured at 4 years of age in the offspring. Multiple linear regression model was used to investigate the association between individual PFAS level and BP of the offspring. Bayesian kernel machine regression (BKMR) was used to analyze the relationship between the PFAS mixture and BP of the offspring, while weighted quantile sum (WQS) regression was utilized for sensitivity analysis. Results A total of 129 mother-child pairs were included in our analysis. In multiple linear regressions, we observed that long-chain PFAS, mainly including perfluorooctane sulfonate (PFOS), perfluorodecanoic acid (PFDA) and perfluoroundecanoic acid (PFUA), was negatively associated with systolic blood pressure (SBP), diastolic blood pressure (DBP) and mean arterial blood pressure (MAP). BKMR showed that an increase in umbilical cord blood PFAS mixture levels was significantly associated with a decrease in SBP, DBP and MAP [Estimated differences (SD): -0.433 (0.161); -0.437 (0.176); -0.382 (0.179), respectively]. The most important component in the association with SBP, DBP, and MAP was PFUA. PFDoA was found to be positively associated with SBP, DBP and MAP in both models. Sensitivity analysis with WQS regression showed consistent results. Conclusion Our findings suggested that umbilical blood PFAS exposure was negatively associated with BP in offspring at 4 years of age, including SBP, DBP, and MAP.

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Section: Discussioncontrasting

confidence: 99%

Perfluoroalkyl substances in umbilical cord blood and blood pressure in offspring: a prospective cohort study

Xu,

Du,

Wang

et al. 2023

Environ Health

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“…The study used data from the JBC study, the participants of which were recruited between Sept 2016 and April 2018; detailed information on the study was provided previously. , Briefly, we recruited 1398 pregnant women who visited the First People’s Hospital of Jiashan or Jiashan Maternal and Child Health Hospital during their first prenatal visit (<16 gestational weeks). Women were eligible for inclusion in the study if they were not diagnosed with major chronic diseases, such as hypertension, hyperlipidemia, diabetes, and heart disease.…”

Section: Methodsmentioning

confidence: 99%

Per- and Poly-fluoroalkyl Substances and Bile Acid Profiles in Pregnant Women

Yang,

Chen,

et al. 2023

Environ. Sci. Technol.

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Alterations in bile acid (BA) profiles are closely associated with adverse outcomes in pregnant women and their offspring and may be one potential pathway underlying the related metabolic effects of per- and poly-fluoroalkyl substances (PFAS) exposure. However, evidence of associations between PFAS exposure and BA profiles in pregnant women is scarce. This study examined the associations of individual PFAS and PFAS mixture with BA profiles of pregnant women. We obtained quantitative data on the plasma concentrations of 13 PFAS and 15 BAs in 645 pregnant women from the Jiashan birth cohort. In Bayesian kernel machine regression models, the PFAS mixture was associated with increased plasma CA, TCA, TCDCA, and GLCA levels but with decreased GCA and LCA concentrations. Furthermore, the PFAS mixture was associated with increased concentrations of total BAs and the secondary/primary BA ratio but with decreased conjugated/unconjugated and glycine/taurine-conjugated BA ratios. PFHxS, PFUdA, PFOS, PFNA, and PFDA were the dominant contributors. The results of the linear regression analysis of individual PFAS were generally similar. Our findings provide the first epidemiological evidence for the associations of a PFAS mixture with BA profiles in pregnant women and may provide explanatory insights into the biological pathways underlying the related metabolic effects of PFAS exposure.

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“…16 The association between PFAS and some pregnancy outcomes has been shown to be modified by fetal sex. 17,18 For example, Borghese et al reported a positive association between first trimester plasma PFOS and PFHxS concentrations and gestational hypertension in pregnant people carrying male, but not female, fetuses. 18 Sex-specific patterns have also been seen in studies measuring circulating levels of proinflammatory cytokines during pregnancy; pregnant people carrying male fetuses tended to have higher concentrations compared with those carrying female fetuses.…”

Section: What This Study Addsmentioning

confidence: 99%

Prenatal exposure to perfluoroalkyl substances and inflammatory biomarker concentrations

Palaniyandi,

Bruin,

Kumarathasan

et al. 2023

Environmental Epidemiology

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Background: Per- and polyfluoroalkyl substances (PFAS) are persistent environmental contaminants that induce immunotoxicity in experimental studies; however, epidemiological evidence—particularly during pregnancy—is scarce. We quantified associations between first trimester plasma perfluorooctanoic acid (PFOA), perfluorooctane sulfonate (PFOS), and perfluorohexane sulfonate (PFHxS) concentrations and third trimester concentrations of inflammatory biomarkers and determined if these associations were modified by fetal sex. Methods: We analyzed data from 1411 participants, recruited between 2008 and 2011, in the Maternal-Infant Research on Environmental Chemicals study. Our primary outcome was a composite inflammatory index derived by summing the z-scores of eight proinflammatory biomarkers. Using multivariable linear regression models, we quantified associations between each PFAS and the inflammatory index and individual biomarkers. We quantified the effects of the PFAS mixture using weighted quantile sum regression, and evaluated effect modification using product terms and sex-stratified models. Results: Each doubling of PFOA and PFHxS was associated with a 0.38 (95% CI, 0.09, 0.67) and 0.21 (95% CI, 0.01, 0.41) SD increase in the proinflammatory index, respectively. A one-quartile increase in the PFAS mixture was associated with a 0.40 (95% CI, 0.09, 0.71) SD increase in the proinflammatory index. In individual models, we observed positive associations between PFAS and concentrations of monocyte chemoattractant protein-1, macrophage inflammatory protein-1β, and matrix metalloproteinases-9; however, the magnitude and precision varied according to the specific PFAS. Sex-specific findings were identified in few PFAS-biomarker associations. Conclusions: PFOA, PFOS, and PFHxS, individually and as a mixture, were positively associated with proinflammatory biomarkers during pregnancy.

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Associations of perfluoroalkyl and polyfluoroalkyl substances with gestational hypertension and blood pressure during pregnancy: A cohort study

Cited by 15 publications

References 58 publications

Perfluoroalkyl substances in umbilical cord blood and blood pressure in offspring: a prospective cohort study

Perfluoroalkyl substances in umbilical cord blood and blood pressure in offspring: a prospective cohort study

Per- and Poly-fluoroalkyl Substances and Bile Acid Profiles in Pregnant Women

Prenatal exposure to perfluoroalkyl substances and inflammatory biomarker concentrations

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