Associations of perfluorooctane sulfonate alternatives and serum lipids in Chinese adults

Cong, Jianping; Chu, Chu; Li, Qing Qing; Zhou, Yang; Qian, Zhengmin; Geiger, Sarah Dee; Vaughn, Michael G.; Zeng, Xiao Wen; Liu, Ru Qing; Hu, Li; Yang, Bo; Chen, Gongbo; Zeeshan, Mohammed; Sun, Xiao; Xiang, Ming; Dong, Guang‐Hui

doi:10.1016/j.envint.2021.106596

Cited by 25 publications

(7 citation statements)

References 53 publications

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“…However, the relationship of human exposure and overweight/ obesity status is still controversial, given concerns about reverse causality and effective dose (Jain 2020). Due to different modeling approaches and inconsistent confounding variables, the results of some studies were not consistent with ours (Averina et Though there is no evidence that showed Cl-PFESAs might be potential obesogens in human beings, our previous epidemiologic studies found serum Cl-PFESAs concentrations were signi cantly positively associated with serum lipids (Cong et al 2021) and the risk of metabolic syndrome (MetS) (Yu et al 2021). In addition, Yao et al (Yao et al 2020) reported multivariate linear regression coe cients of 9.80% (95% CI: 6.09, 13.63) for cholesterol (mmol/L), 9.59% (95% CI: 5.29, 14.07) for low-density lipoprotein cholesterol (mmol/L), 12.34% (95% CI: 2.80, 2.88) for triglycerides (mmol/L), higher 6:2 Cl-PFESA per lnng/mL concentrations, respectively, which suggests potential elevated lipid parameters from exposure to 6:2 Cl-PFESA.…”

Section: Discussioncontrasting

confidence: 58%

Non-monotonic Association Between Chlorinated Polyfluorinated Ether Sulfonic Acids Exposure and the Risk of Overweight/Obesity Status in Adults

et al. 2022

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BackgroundChlorinated poly uorinated ether sulfonic acids (Cl-PFESA 6:2 and 8:2), used as per uorooctane sulfonate (PFOS) alternatives, affect lipid metabolism in vivo and in vitro studies. The association between Cl-PFESAs exposure and the prevalence of overweight /obesity in human is unknown. ObjectivesWe investigated associations of serum 6:2 Cl-PFESA and 8:2 Cl-PFESA with overweight/obesity status in adults. MethodsWe quanti ed four per uoroalkyl substances (PFAS), including 6:2 Cl-PFESA, 8:2 Cl-PFESA, PFOS, and per uorooctanoic acid (PFOA) in 1275 Chinese adults from the Isomers of C8 Health Project in China study. Participants were categorized into normal weight group [body mass index (BMI) < 25 kg/m 2 ] and overweight/obesity group (BMI ≥ 25 kg/m 2 ). ResultsAdjusted for potential confounders, BMI in the second quartile of each ln-ng/mL greater concentration of 6:2 Cl-PFESA and 8:2 Cl-PFESA were 0.45 [95% con dence interval (CI): 0.08, 0.82], and 0.39 (95% CI:0.03, 0.76) signi cantly higher than the lowest quartile, respectively. Cl-PFESAs displayed inverted U-shaped associations with the risk of overweight/obesity, and the in ection point of 6:2 Cl-PFESA and 8:2 Cl-PFESA were 1.80 ng/mL, 0.01 ng/mL, respectively. PFOS was associated with waist circumference (WC) but not BMI in each quartile. For PFOA, the associations with outcomes were linearly positive (P for trend < 0.05). ConclusionsThis study reports the rst observations on non-monotonic associations between serum 6:2 Cl-PFESA and 8:2 Cl-PFESA concentrations and the prevalence of overweight/obesity in adults. More epidemiological investigations are required to con rm the observed associations.

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Section: Discussioncontrasting

confidence: 58%

Non-monotonic Association Between Chlorinated Polyfluorinated Ether Sulfonic Acids Exposure and the Risk of Overweight/Obesity Status in Adults

et al. 2022

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“…Previous research has also linked Cl-PFESAs to adverse birth outcomes, such as premature birth and low birth weight, as well as changes in vitamin D and hormone levels [20,[39][40][41]. Epidemiological evidence also suggested that Cl-PFESAs further affected adult health, including hypertension, thyroid hormone disturbances, dyslipidemia, and liver function abnormalities [42][43][44][45]. Thus, potential health risks should be considered when using these novel PFASs as substitutes.…”

Section: Discussionmentioning

confidence: 99%

The Association between Prenatal Exposure to Per- and Polyfluoroalkyl Substances and Respiratory Tract Infections in Preschool Children: A Wuhan Cohort Study

Huang,

Li,

Deng

et al. 2023

Toxics

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This study investigates the association between prenatal exposure to per- and polyfluoroalkyl substances (PFASs) and the incidence and frequency of respiratory tract infections (RTIs) in preschool children. We selected 527 mother–infant pairs from Wuhan Healthy Baby Cohort (WHBC), China. Ten PFASs were measured in umbilical cord serum, and we collected data on common RTIs in preschool children aged 4 years through a questionnaire. Associations of single PFASs with the incidence and frequency of RTIs were analyzed via Logistic regression and Poisson regression, while the collective effect was assessed by weighted quantile sum (WQS) regression. Furthermore, stratified and interaction analyses were performed to evaluate if there were sex-specific associations. We found a positive correlation between perfluorododecanoic acid (PFDoDA) and the incidence of tonsillitis, with several PFASs also showing positive associations with its frequency. Moreover, perfluorotridecanoic acid (PFTrDA) showed a positive link with the frequency of common cold. The results of WQS regression revealed that after adjusting for other covariates, PFASs mixture showed a positive association with the incidence of tonsillitis, the frequency of common cold, and episodes. In particular, perfluoroundecanoic acid (PFUnDA), PFDoDA, PFTrDA, perfluorodecanoic acid (PFDA) and 8:2 chlorinated polyfluorinated ether sulfonic acid (8:2 Cl-PFESA) had the most significant impact on this combined effect. The results suggest that both single and mixed exposures to PFASs may cause RTIs in preschool children. However, there was no statistically significant interaction between different PFASs and sex.

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“…62,87,111 Analysis of participants in the Isomers of C8 Project (China, 1238 participants) showed that both PFOA and PFOS were associated with total serum cholesterol and LDL-C but not HDL-C or triglycerides. 112 Cross-sectional analysis of a contaminated community in Laizhou Bay, China (162 participants), showed that PFOA (the predominant PFAS) was linked with total serum cholesterol and LDL-C but not HDL-C or triglycerides. 113 The PFAS Health study in Australia (1406 participants) analyzed participants living in 3 communities known to have PFAS-contaminated water.…”

Section: Dyslipidemia and Atherosclerosismentioning

confidence: 99%

Perfluoroalkyl/Polyfluoroalkyl Substances: Links to Cardiovascular Disease Risk

Schlezinger,

Gokce

2024

Circulation Research

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Conservative estimates by the World Health Organization suggest that at least a quarter of global cardiovascular diseases are attributable to environmental exposures. Associations between air pollution and cardiovascular risk have garnered the most headlines and are strong, but less attention has been paid to other omnipresent toxicants in our ecosystem. Perfluoroalkyl and polyfluoroalkyl substances (PFASs) are man-made chemicals that are extensively used in industrial and consumer products worldwide and in aqueous film-forming foam utilized in firefighting. As such, our exposure to PFAS is essentially ubiquitous. Given the long half-lives of these degradation-resistant chemicals, virtually, all people are carrying a body burden of PFAS. Health concerns related to PFAS are growing such that the National Academies of Sciences, Engineering and Medicine has recommended standards for clinical follow-up of individuals with high PFAS blood levels, including prioritizing screening for dyslipidemia. The link between PFAS and dyslipidemia has been extensively investigated, and evidence for associations is compelling. However, dyslipidemia is not the only cardiovascular risk factor with which PFAS is associated. Here, we review the epidemiological evidence for links between PFAS of concern identified by the National Academies of Sciences, Engineering and Medicine and risk factors for cardiovascular disease, including overweight/obesity, glucose intolerance, hypertension, dyslipidemia, and hyperuricemia. Moreover, we review the potential connections of PFAS with vascular disease and atherosclerosis. While observational data support associations between the National Academies of Sciences, Engineering and Medicine PFAS and selected cardiac risk factors, additional research is needed to establish causation and better understand how exposure to PFAS leads to the development of these conditions.

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Associations of perfluorooctane sulfonate alternatives and serum lipids in Chinese adults

Cited by 25 publications

References 53 publications

Non-monotonic Association Between Chlorinated Polyfluorinated Ether Sulfonic Acids Exposure and the Risk of Overweight/Obesity Status in Adults

Non-monotonic Association Between Chlorinated Polyfluorinated Ether Sulfonic Acids Exposure and the Risk of Overweight/Obesity Status in Adults

The Association between Prenatal Exposure to Per- and Polyfluoroalkyl Substances and Respiratory Tract Infections in Preschool Children: A Wuhan Cohort Study

Perfluoroalkyl/Polyfluoroalkyl Substances: Links to Cardiovascular Disease Risk

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