Associations of phase angle with platelet-activating factor metabolism and related dietary factors in healthy volunteers

Abstract

IntroductionPhase angle (PA) is derived from bioelectrical impedance analysis (BIA). It reflects cell membrane function and decreases in disease. It is affected by inflammation, oxidative stress, and diet. Platelet-activating factor (PAF) is a potent inflammatory lipid mediator. Its levels, along with the activity of its metabolic enzymes, including CDP-choline:1-alkyl-2-acetyl-sn-glycerol-cholinephosphotransferase, acetyl-CoA:lyso-PAF-acetyltransferases, and PAF-AH/Lp-PLA2 are also related to dietary factors, such as the dietary antioxidant capacity (DAC). The aim of the study was to estimate whether the PAF metabolic circuit and related dietary factors are associated with PA in healthy volunteers.MethodsIn healthy subjects, PAF, its metabolic enzyme activity, and erythrocyte fatty acids were measured, while desaturases were estimated. Food-frequency questionnaires and recalls were used, and food groups, macronutrient intake, MedDietScore, and DAC were assessed. Lifestyle and biochemical variables were collected. DXA and BIA measurements were performed.ResultsLp-PLA2 activity was positively associated with PA (rho = 0.651, p < 0.001, total population; rho = 0.780, p < 0.001, women), while PAF levels were negatively associated with PA only in men (partial rho = −0.627, p = 0.012) and inversely related to DAC. Estimated desaturase 6 was inversely associated with PA (rho = −0.404, p = 0.01, total sample). Moreover, the DAC correlated positively with PA (rho = 0.513, p = 0.03, women). All correlations were adjusted for age, body mass index, and sex (if applicable).ConclusionPA is associated with PAF levels and Lp-PLA2 activity in a gender-dependent fashion, indicating the involvement of PAF in cell membrane impairment. The relationship of PA with DAC suggests a protective effect of antioxidants on cellular health, considering that antioxidants may inhibit PAF generation.

Association between oxidative balance score and sarcopenia in US adults: NHANES 2011–2018

“…Research supports the use of PA as a biomarker to predict sarcopenia. Lower PA values were associated with a higher risk of sarcopenia, which emphasizes the important role of antioxidant-rich diets in reducing the risk of this disease ( 61 , 62 ).…”

Efficacy of a new immunonutrition formula with extra virgin olive oil in the reduction of complications in surgeries of upper digestive tract tumors

“…There is evidence that the phase angle is negatively correlated with proinflammatory molecules such as CRP, TNF-α, interleukin-6 and interleukin-10, both in healthy people and in chronic disease situations. Some data also point to the relationship between the phase angle and markers of oxidative stress and antioxidant intake ( 31 , 32 ). In patients undergoing surgery for head and neck cancer, the use for 8 days of an immunomodulatory formula, with a composition similar to that used in the present study, produced a significant increase in the phase angle ( 33 ).…”

Diagnostic Criteria and Measurement Techniques of Sarcopenia: A Critical Evaluation of the Up-to-Date Evidence

“…It should be noted that the type of machine [54] as well as the measuring position (standing vs. supine) [55] may differentiate deriving values for the phase angle, suggesting that, at best, the reference values used should be measured with the same machine. Physiological factors [56,57], diet [58,59] and diseases [47] may also affect phase angle values.…”