Associations of Physical Activity and Sedentary Behaviour with Vision-Threatening Diabetic Retinopathy in Indonesian Population with Type 2 Diabetes Mellitus: Jogjakarta Eye Diabetic Study in the Community (JOGED.COM)

Dharmastuti, D P; Agni, Angela Nurini; Widyaputri, Felicia; Pawiroranu, Suhardjo; Sofro, Zaenal Muttaqien; Wardhana, Firman Setya; Supanji, Supanji; Widayanti, Tri Wahyu; Kotha, Satya P; Gupta, Prateek; Sasongko, Muhammad Bayu

doi:10.1080/09286586.2017.1367410

Cited by 22 publications

(23 citation statements)

References 30 publications

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“…Some evidence suggests that AE may protect retinal cells from diabetes-induced injuries by inhibition of the underlying inflammatory and oxidative stress pathways (Dharmastuti et al, 2018). Loprinzi, Brodowicz, Sengupta, Solomon, and Ramulu (2014) In a cohort study in diabetic patients, Kuwata et al (2017) found that higher levels of AE are associated with a lower incidence of DR,…”

Section: Ae and Drmentioning

confidence: 99%

Aerobic exercise can modulate the underlying mechanisms involved in the development of diabetic complications

Yaribeygi

Butler²,

Sahebkar

2019

Journal Cellular Physiology

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Diabetes mellitus is a highly prevalent metabolic disorder that affects many molecular pathways, causing a shift from a physiologic to a pathophysiologic state. Alterations in the molecular pathways promote diabetic complications and, thus, many medical and nonmedical therapies have been directed at preventing these complications. Despite the beneficial effects on moderating glycemic control, medical therapies may also have unfavorable side effects. This makes nonmedical therapeutic approaches more attractive due to lower pharmacological side effects of these strategies compared to medical agents. Aerobic exercise is now considered as a major nonmedical strategy that can promote beneficial and protective effects to counteract the development of diabetic complications via attenuation of the major molecular mechanisms involved in diabetes.

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Section: Ae and Drmentioning

confidence: 99%

Aerobic exercise can modulate the underlying mechanisms involved in the development of diabetic complications

Yaribeygi

Butler²,

Sahebkar

2019

Journal Cellular Physiology

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“…No associations were found in type 1 diabetes patients in the Pittsburgh study [ 4 ], and a protective effect of PA on DR risk was observed in women only in the WESDR study [ 5 ]. Studies conducted in type 2 diabetic patients found that higher levels of PA were associated with milder DR and less likelihood of DR onset; these studies were cross-sectional in design or limited by small sample size [ 6 – 8 ]. There is only one longitudinal study recently published, reporting a lower DR incidence in participants with higher PA levels, but this study was conducted in a small sample of the cohort during 2-year follow-up [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

Effect of physical activity on reducing the risk of diabetic retinopathy progression: 10-year prospective findings from the 45 and Up Study

Yan

Han

et al. 2021

PLoS ONE

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Objective To examine the association of physical activities (PA) with diabetic retinopathy (DR) progression based on a 10-year follow-up of a large cohort of working-aged diabetic populations in Australia. Methods Nine thousand and eighteen working-aged diabetic patients were enrolled from the baseline of the 45 and Up Study from New South Wales, Australia. Self-reported PA collected by questionnaire at baseline in 2006 was graded into low (<5 sessions/week), medium (≥5–14), and high (≥14) levels. Retinal photocoagulation (RPC) treatment during the follow-up period was used as a surrogate for DR progression and was tracked through the Medicare Benefits Schedule, which was available from 2004 to 2016. Cox regression was used to estimate the association between PA and RPC incidence. Results In the fully adjusted model, higher PA level was significantly associated with a lower risk of RPC incident (Cox-regression, p-value for trend = 0.002; medium vs. low, hazard ratio (HR) = 0.78, 95% Confidence Interval (CI): 0.61–0.98; high vs. low, HR = 0.61, 95%CI: 0.36–0.84. In addition, gender, body mass index, insulin treatment, family history of diabetes, history of cardiovascular disease were significant effect modifiers for the association between PA and RPC. Conclusions Higher PA level was independently associated with a lower risk of DR progression among working-aged diabetic populations in this large cohort study.

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“…Detailed study sampling and methodology have previously been described (23)(24)(25). Briefly, JOGED.COM (Jogjakarta Eye Diabetic Study in the Community) was a community-based cross-sectional study recruiting participants aged .30 years with type 2 diabetes confirmed by their family physician (using one of the following criteria: fasting plasma glucose $126 mg/dL, random glucose $200 mg/dL, or A1C $6.5%).…”

Section: Methodsmentioning

confidence: 99%

Estimated Resting Metabolic Rate and Body Composition Measures Are Strongly Associated With Diabetic Retinopathy in Indonesian Adults With Type 2 Diabetes

et al. 2018

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Associations of Physical Activity and Sedentary Behaviour with Vision-Threatening Diabetic Retinopathy in Indonesian Population with Type 2 Diabetes Mellitus: Jogjakarta Eye Diabetic Study in the Community (JOGED.COM)

Abstract: In this study, prolonged daily sedentary activity was strongly associated with VTDR. This finding suggests that public health campaign for reducing daily sedentary activities in individuals with type 2 diabetes may offer benefit to reduce the burden of DR and VTDR.

Cited by 22 publications

References 30 publications

Aerobic exercise can modulate the underlying mechanisms involved in the development of diabetic complications

Aerobic exercise can modulate the underlying mechanisms involved in the development of diabetic complications

Effect of physical activity on reducing the risk of diabetic retinopathy progression: 10-year prospective findings from the 45 and Up Study

Estimated Resting Metabolic Rate and Body Composition Measures Are Strongly Associated With Diabetic Retinopathy in Indonesian Adults With Type 2 Diabetes

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