Associations of Physical Activity Energy Expenditure with Nutritional-Inflammatory Markers in Hemodialysis Patients

ZUSAMMENFASSUNGDie Erkennung und Behandlung der Mangelernährung gehört zum klinischen Standard, wie es sich auch an einer verbesserten Ernährungssituation von Dialysepatienten in rezenten Untersuchungen widerspiegelt. Noch relativ neu ist der etwas unhandliche Begriff „chronic disease related malnutrition“ (C-DRM), der den immer noch gebräuchlicheren Begriff des „protein-energy wasting“ (PEW) ablösen sollte, da er die bei Dialysepatienten auch zur Mangelernährung beitragenden Ursachen besser widerspiegelt. In diesem Artikel wird gezeigt, wie eine C-DRM diagnostiziert werden kann. Es wird auf die wesentlichen Stellparameter für eine gute Ernährung beim Dialysepatienten eingegangen. Neben dem allgemeinen Kalorienbedarf findet dabei als Makronährstoff ausschließlich das Eiweiß (und das darin immer auch vorhandene Phosphat) Erwähnung. An Mineralien wird außerdem auf Natrium und Kalium eingegangen. Beim Vitaminbedarf werden nicht nur die wasserlöslichen – und damit während einer Dialyse herausgewaschenen – Vitamine behandelt, sondern auch die fettlöslichen. Auch an Vitamin D und K mangelt es nämlich häufig. Abschließend wird auf die therapeutischen Möglichkeiten wie die Diätberatung bzgl. einer verbesserten natürlichen Kost, Nahrungsergänzungsmittel, enterale Ernährung via perkutane endoskopische Gastrostomie (PEG) und den Nutzen der parenteralen Ernährung eingegangen.

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Occupational physical activity: the good, the bad, and the proinflammatory

Jordakieva,

Hasenoehrl,

Steiner

et al. 2023

Front. Med.

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BackgroundPhysical activity (PA) is beneficial for preventing several conditions associated with underlying chronic inflammation, e. g., cardiovascular disease (CVD) and cancer. While an active lifestyle appears to have anti-inflammatory effects, high levels of occupational PA (OPA) were associated with inflammation and elevated mortality risks. We aimed to summarize the current knowledge (1) on the association between inflammation and OPA and (2) its implications for health and mortality.Methods and resultsThis mini-review summarized relevant literature published before January 2023 using established scientific databases and sources. For the primary outcome, observational studies (S) reporting immunological effects (O) in subjects (P), with high (I) vs. low OPA (C), were included. For secondary outcomes, i.e., morbidity and mortality associated with inflammatory processes, (systematic) reviews were included. While “active” occupations and “moderate” OPA appear to have beneficial effects, low (particularly sedentary) and “high-intensity” OPA (particularly including heavy lifting tasks) were associated with inflammation and (CVD and cancer-related) mortality; higher leisure-time PA has been almost consistently associated with lower proinflammatory markers and all-cause mortality risks. Workplace interventions appear to counter some of the observed health effects of unfavorable work strain.ConclusionThe few studies addressing OPA “intensity” and inflammatory markers are largely heterogeneous regarding OPA classification and confounder control. Sedentary and “heavy” OPA appear to promote proinflammatory effects. In addition to targeted management of work-related physical strain and hazardous environmental co-factors, occupational health providers should focus on employer-initiated exercise interventions and the promotion of leisure-time PA.

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Associations of Physical Activity Energy Expenditure with Nutritional-Inflammatory Markers in Hemodialysis Patients

Abstract: Greater physical activity assessed by PAEE was associated with indicators of better nutritional and inflammation status. These results indicate opportunities for improving outcomes in MHD patients by counseling and treatment intervention.

Cited by 3 publications

References 48 publications

Obesity phenotypes are, in part, associated with physical activity in diabetic hemodialysis patients

Obesity phenotypes are, in part, associated with physical activity in diabetic hemodialysis patients

Ernährungszustand bei Dialysepatienten

Occupational physical activity: the good, the bad, and the proinflammatory

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