Associations of placental weight with maternal and cord blood hormones

Λάγιου, Παγώνα; Hsieh, Chung‐Cheng; Samoli, Evangelia; Lagiou, Areti; Xu, Biao; Yu, Guo‐Pei; Onoyama, Sagano; Chie, Lucy; Vatten, Lars J.; Adami, Hans‐Olov; Trichopoulos, Dimitrios; Williams, Michelle A.

doi:10.1016/j.annepidem.2013.08.003

Cited by 15 publications

(17 citation statements)

References 19 publications

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“…Adiponectin and leptin levels in this study were comparable to those from Japanese study (Nakano et al 2012) and other studies in Asian countries (Chou et al 2011;Kim et al 2016). Contrary, cord blood adiponectin in our study showed lower level compared to the previous studies from North America and Europe (Brynhildsen et al 2013;Lagiou et al 2013;Luo et al 2013;Ashley-Martin et al 2017). Similarly, compared to Canadian study, leptin level in our study was lower.…”

Section: Discussionsupporting

confidence: 75%

Association of prenatal exposure to perfluoroalkyl substances with cord blood adipokines and birth size: The Hokkaido Study on environment and children's health

Minatoya

Itoh

Miyashita

et al. 2017

Environmental Research

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Perfluoroalkyl substances (PFASs) are synthetic chemicals that persist in the environment and in humans. There is a possible association between prenatal PFASs exposure and both neonate adipokines and birth size, yet epidemiological studies are very limited. The objective of this study was to examine associations of prenatal exposure to PFASs with cord blood adipokines and birth size. We conducted birth cohort study, the Hokkaido Study. In this study, 168 mother-child pairs were included. Perfluorooctane sulfonate (PFOS) and perfluorooctanoate (PFOA) in maternal blood were determined by liquid chromatography tandem mass spectrometry. Cord blood adiponectin and leptin levels were measured by ELISA and RIA, respectively. Birth weight and ponderal index (PI) were obtained from birth record. The median maternal PFOS and PFOA were 5.1 and 1.4ng/mL, respectively. The median total adiponectin and leptin levels were 19.4μg/mL and 6.2ng/mL, respectively. Adjusted linear regression analyses found that PFOS level was positively associated with total adiponectin levels (β=0.12, 95% CI:0.01, 0.22), contrary was negatively associated with PI (β=-2.25, 95% CI: -4.01, -0.50). PFOA level was negatively associated with birth weight (β=-197, 95% CI: -391, -3). Leptin levels were not associated with PFASs levels. PFOS and adiponectin levels showed marginal dose-response relationship and both PFOS and PFOA and birth size showed significant dose-response relationships. Results from this study suggested that prenatal PFASs exposure may alter cord blood adiponectin levels and may decrease birth size.

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Section: Discussionsupporting

confidence: 75%

Association of prenatal exposure to perfluoroalkyl substances with cord blood adipokines and birth size: The Hokkaido Study on environment and children's health

Minatoya

Itoh

Miyashita

et al. 2017

Environmental Research

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“…Leptin levels in our study were lower compared to the recently reported levels from Canadian study (Ashley-Martin et al, 2014). Adiponectin levels in cord blood from the previous studies showed relatively higher levels in Caucasian population (Brynhildsen et al, 2013;Luo et al, 2013;Lagiou et al, 2013) compared to Chinese population (Lagiou et al, 2013). As previously reported (West et al, MINATOYA 13 2014), leptin and adiponectin levels vary among ethnicities, and in adult study Asian population showed lower adiponectin levels compared to those of European people (Mente et al, 2010).…”

Section: Adipokine Levels In Cord Bloodsupporting

confidence: 48%

Prenatal di-2-ethylhexyl phthalate exposure and cord blood adipokine levels and birth size: The Hokkaido study on environment and children's health

Minatoya

Araki

Miyashita

et al. 2017

Science of The Total Environment

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Di-2-ethylhexyl phthalate (DEHP) is one of the most widely used phthalates. Metabolites of DEHP are detectable in majority of the population. Findings on adverse health outcomes, particularly birth weight in association with prenatal exposure to DEHP remain equivocal. Besides, there is insufficient evidence to address influence on metabolic function from epidemiological studies. Thus, our objective was to investigate cord blood adipokine levels and birth size in association with prenatal DEHP exposure in prospective birth cohort study. Mono-2-methylhexyl phthalate (MEHP), primary metabolite of DEHP was determined as exposure by using maternal blood sample of 3rd trimester. Leptin and adiponectin levels in cord blood were measured as markers of metabolic function. Birth weight and length were obtained from birth record. Association between maternal MEHP levels and cord blood adiponectin and leptin levels, birth weight and ponderal index (PI) were examined for 167 mother-child pairs who had both MEHP and cord blood adipokine measurements. The median MEHP level was 8.81ng/ml and the detection rate was 100%. There was no sex difference in MEHP levels. Both leptin and adiponectin levels were higher in girls than in boys. MEHP level was positively associated with adiponectin level among boys and was negatively associated with leptin level among girls. MEHP level were negatively associated with PI only in girls and this could be due to decreased leptin level. This study suggested that prenatal DEHP exposure may be associated with cord blood adipokine and birth size. The influence potentially be sex-specific and could be more significant in girls.

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“…What is missing in this sequence of events is a link between the size of the placenta and breast cancer risk, since placental weight may reflect the production of relevant pregnancy hormones [14]. There is currently little data available to show any association of placental weight with breast cancer risk [15][16][17].…”

Section: Introductionmentioning

confidence: 98%

Size at birth and risk of breast cancer: update from a prospective population-based study

et al. 2015

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Birth size variables (birth weight, birth length and head circumference) have been reported to be positively associated with adult breast cancer risk, whereas a possible association of placental weight has not been adequately studied. It has also been suggested that maternal height may modify the association of birth size with adult breast cancer risk, but this has not been studied in detail. We updated a long-term follow-up of 22,931 Norwegian women (average of 51 years of follow up during which 870 women were diagnosed with breast cancer) and assessed placental weight in relation to breast cancer risk, in addition to providing updated analyses on breast cancer risk in relation to birth weight, birth length and head circumference. Placental weight was not associated with risk for breast cancer in adulthood, but there was a positive association of breast cancer risk with birth length (HR 1.13, 95% CI 1.05-1.21, per 2 cm increment), though not with birth weight (HR 1.02, 95% CI 0.95-1.10 per 0.5 kg increment). For birth length, the graded increase in risk was particularly strong among women whose mothers were relatively tall (p for trend, 0.001), compared to the trend among women whose mothers were relatively short (p for trend, 0.221). The results showed a robust and positive association of birth length with breast cancer risk, and may be especially strong in women whose mothers were relatively tall. We found no association of placental weight with risk for breast cancer.

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Associations of placental weight with maternal and cord blood hormones

Cited by 15 publications

References 19 publications

Association of prenatal exposure to perfluoroalkyl substances with cord blood adipokines and birth size: The Hokkaido Study on environment and children's health

Association of prenatal exposure to perfluoroalkyl substances with cord blood adipokines and birth size: The Hokkaido Study on environment and children's health

Prenatal di-2-ethylhexyl phthalate exposure and cord blood adipokine levels and birth size: The Hokkaido study on environment and children's health

Size at birth and risk of breast cancer: update from a prospective population-based study

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