Associations of plasma homocysteine levels with peripheral systolic blood pressure and noninvasive central systolic blood pressure in a community-based Chinese population

Momin, Mohetaboer; Fan, Fangfang; Li, Jianping; Jia, Jia; Qi, Litong; Zhang, Yan; Huo, Yong

doi:10.1038/s41598-017-06611-3

Cited by 15 publications

(14 citation statements)

References 46 publications

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“…Homocysteine (Hcy) has been involved in the pathogenesis of hypertension by producing endothelial injury [3,4], increasing oxidative stress [5], stimulating the proliferation of vascular smooth muscle cells (VSMCs) [6], and altering the elastic properties of the vascular wall [7]. Elevated Hcy and its related genetic variants have been associated with blood pressure [8][9][10][11][12], hypertension [13][14][15], and related vascular complications, e.g., atherosclerosis [16,17], coronary heart disease [18,19], and stroke [20,21], in humans. In the process of Hcy-induced hypertension, the endothelial injury resulting from Hcy promotes platelet consumption and adherence which stimulates the proliferation of VSMCs through releasing mitogenic factors [22], thereby contributing to atherosclerosis, arterial stiffness, and high blood pressure [23,24] Furthermore, platelet activation has been associated with Hcy [25] but also hypertension [26] in population studies.…”

Section: Introductionmentioning

confidence: 99%

Modification of Platelet Count on the Association between Homocysteine and Blood Pressure: A Moderation Analysis in Chinese Hypertensive Patients

Zhang

Shi

et al. 2020

International Journal of Hypertension

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Background. Platelet consumption followed by homocysteine-induced endothelial injury suggests a crosstalk between platelet activation and homocysteine on hypertension. Platelet count has been found to modify the effect of folic acid on vascular health. However, whether platelet count could modify the contribution of homocysteine to blood pressure (BP) remains unclear. Methods. Leveraging a community-based cross-sectional survey in 30,369 Chinese hypertensive patients (mean age 62 years, 52% female), we examined the moderation of platelet count on the association between serum homocysteine and BP by constructing hierarchical multiple regression models, adjusting for conventional risk factors. If adding the interaction term of homocysteine and platelet count could explain more variance in BP and the interaction is significant, then we believe that moderation is occurring. Results. e association between serum homocysteine and diastolic BP was significantly stronger (β = 0.092 vs. 0.035, P � 0.004) in participants with low platelet count (<210 × 10 9 /L) than in those with high platelet count (≥210 × 10 9 /L). Adding the interaction term of homocysteine and platelet count additionally explained 0.05% of the variance in diastolic BP (P � 0.0001), and the interaction was significant (β = − 0.021, P < 0.001). Excluding participants receiving antihypertensive medications did not change our results. Conclusions. e association between homocysteine and BP was significantly stronger in participants with low vs. high platelet count and was partially moderated by platelet count. ese results indicate that platelet count may be useful in the identification of individuals who are most beneficial to reducing-homocysteine treatments but this usefullness still needs further investigation.

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Section: Introductionmentioning

confidence: 99%

Modification of Platelet Count on the Association between Homocysteine and Blood Pressure: A Moderation Analysis in Chinese Hypertensive Patients

Zhang

Shi

et al. 2020

International Journal of Hypertension

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“…The principle of the method has been described in detail previously. 26 Other laboratory parameters were measured at baseline using a Roche C8000 Automatic Analyzer (Basel, Switzerland).…”

Section: Blood Sample Collection and Laboratory Methodsmentioning

confidence: 99%

<p>Joint Effects of Plasma Homocysteine Concentration and Traditional Cardiovascular Risk Factors on the Risk of New-Onset Peripheral Arterial Disease</p>

Liu

Fan

Liu

et al. 2020

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Purpose: Hyperhomocysteinemia is an independent risk factor for cardio-and cerebrovascular diseases. However, the relationship between plasma homocysteine (Hcy) concentration and peripheral arterial disease (PAD) has not been completely characterized. The aim of the present study was to determine the relationship between plasma Hcy concentration and new-onset PAD and to assess the effects of combinations of Hcy and traditional cardiovascular risk factors. Patients and Methods: We conducted a prospective community-based cohort study of 3119 Chinese participants who did not have PAD at baseline, with a median follow-up period of 2.30 years. We used multivariate logistic regression models to evaluate the relationship between high Hcy (≥10µmol/L) and new-onset PAD. The effects of combinations of high Hcy and traditional cardiovascular risk factors were assessed using logistic regression analysis. Results: After adjustment for 14 covariates, high Hcy concentration was significantly associated with new-onset PAD (odds ratio [OR]=2.08, 95% confidence interval [CI]: 1.-08-4.03, P=0.030). Smokers with high Hcy concentration were substantially more likely to have new-onset PAD than non-smokers with normal Hcy concentration (OR=4.44, 95% CI: 1.77-11.12, P=0.001). The effect of diabetes on PAD became significant when present in combination with high Hcy concentration (OR=3.67, 95%

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“…15 The mean level of Hcy in our sample was 10.5 µmol/L, which was greater than previously reported among American population in the National Health and Nutrition Examination Survey (7.72 µmol/L) and lower than mean value reported among Chinees population (11.96 µmol/L). 16,17 In the last decade, epidemiological observations have reported that Hcy status is linked to cardiovascular disease and was suggested to be an independent predictor of cardiac death among adults. 18 In the current study, Hcy levels varied significantly between males and females.…”

Section: Multivariate Analysis For Hcy Status and Msmentioning

confidence: 99%

The association between plasma homocysteine level and metabolic syndrome

Saeed

Shehri²,

Saleb³

et al. 2020

SMJ

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To investigate the association between plasma homocysteine (Hcy) status and metabolic syndrome (MS) among Saudi patients attending King Abdulaziz Medical City in Riyadh, Saudi Arabia. Methods: A record-based cross-sectional study of 446 patients was carried out. All consecutive plasma Hcy levels from 2015 to 2018 were extracted. International Diabetes Federation criteria for MS were used to classify the patients. A multivariate regression model was Original Article developed to examine the associations between plasma Hcy and MS. Results: The mean plasma Hcy level was 10.52 µmol/L, and 40% of the patients exhibited elevated Hcy status. Male patients had significantly elevated Hcy levels compared to female patients (p<0.001). In addition, plasma Hcy levels were significantly higher in patients diagnosed with diabetes (p=0.021) and hypertension (p<0.001). The prevalence of MS within the study population was 51%. Homocysteine levels were associated with the presence of MS independent of demographic, anthropometric and biochemical variables (odd ratio 1.018; 95% confidence intervals 1.011-1.047). Conclusion: Plasma Hcy levels were elevated in 40% of the MS patients. Homocysteine had weak association with the presence of MS. Additionally, it was associated with some of its components individually. This study has raised the importance of investigating the association between Hcy status and MS among a representative sample of Saudi population. Additionally, examining possible association and interaction between Hcy level and specific component of MS is suggested to be explored in future studies.

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Associations of plasma homocysteine levels with peripheral systolic blood pressure and noninvasive central systolic blood pressure in a community-based Chinese population

Cited by 15 publications

References 46 publications

Modification of Platelet Count on the Association between Homocysteine and Blood Pressure: A Moderation Analysis in Chinese Hypertensive Patients

Modification of Platelet Count on the Association between Homocysteine and Blood Pressure: A Moderation Analysis in Chinese Hypertensive Patients

<p>Joint Effects of Plasma Homocysteine Concentration and Traditional Cardiovascular Risk Factors on the Risk of New-Onset Peripheral Arterial Disease</p>

The association between plasma homocysteine level and metabolic syndrome

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