1995
DOI: 10.1164/ajrccm.152.6.8520758
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Associations of PM10 and airborne iron with respiratory health of adults living near a steel factory.

Abstract: The association between daily PM10 (particles with a median aerodynamic diameter of < or = 10 microns) and iron particle concentrations and respiratory health was studied in a population of adults selected for current or recent bronchodilator use. Acute changes in respiratory health were measured as changes in peak expiratory flow (PEF), and daily prevalence of respiratory symptoms and medication use as recorded in a diary. The study period was October 11 through December 22, 1993. The study population include… Show more

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Cited by 97 publications
(59 citation statements)
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“…As the exposure misclassification is probably random, this biases the effect-estimates of iron and silicon more towards no association than the other elements. A panel of adult asthma patients in the Netherlands showed an association between elemental concentrations and respiratory health [10]. In that study, iron concentrations were related to PEF, the prevalence of medication use and the prevalence of moderate or severe respiratory symptoms (shortness of breath and attacks of shortness of breath with wheeze but not phlegm).…”
Section: Discussionmentioning
confidence: 88%
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“…As the exposure misclassification is probably random, this biases the effect-estimates of iron and silicon more towards no association than the other elements. A panel of adult asthma patients in the Netherlands showed an association between elemental concentrations and respiratory health [10]. In that study, iron concentrations were related to PEF, the prevalence of medication use and the prevalence of moderate or severe respiratory symptoms (shortness of breath and attacks of shortness of breath with wheeze but not phlegm).…”
Section: Discussionmentioning
confidence: 88%
“…Nickel, zinc, vanadium and iron were included because of the capability of these transition metals to generate radicals in toxicological studies [3±6, 8,9]. Additional reasons for the inclusion of vanadium and iron were that vanadium can serve as a tracer for oil combustion and iron has been shown to be related to acute effects on respiratory health [10]. Silicon, sodium and lead were included as possible tracers for soil dust, sea spray, and leaded car fuel, respectively.…”
Section: Methodsmentioning
confidence: 99%
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“…It has been reported that smokers are less responsive than nonsmokers due to altered lung function and an increase in mucus, both of which could influence dose in the different regions of the lung [31]. It has also been suggested that smokers are more responsive than nonsmokers: in a study reported by DUSSELDORP et al [32], separate analyses in a small group of smokers (n=9) suggested a greater susceptibility of smokers to PM10 pollution. Since it seems unclear how passive smoking affects susceptibility to air pollution, smokers, exsmokers and nonsmokers were included in the present study.…”
Section: Discussionmentioning
confidence: 98%
“…Research has shown that the size of inhaled particles greatly determines the toxicological and immunological effects. In general, the effects are much greater for submicrometer (d < 1 µm) and ultrafine (d < 0.1 µm) particles (Dusseldorp et al, 1995;Biswas and Wu, 2005;Oberdörster et al, 2005;Maynard, 2006;Ny and Lee, 2011). Consequently, there is a need to limit the emission of such particles.…”
Section: Introductionmentioning
confidence: 99%