Associations of preoperative serum high-density lipoprotein cholesterol and low-density lipoprotein cholesterol levels with the prognosis of ovarian cancer

Abstract

BackgroundThe effect of serum lipids on ovarian cancer is controversial. We conduct this study to evaluate the prognostic value of preoperative plasma lipid pro le in patients with ovarian cancer. MethodsThe medical records of 156 epithelial ovarian cancer patients who underwent surgical resection in our department were retrospectively reviewed and analyzed. Serum lipids pro les, including total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), triglyceride (TG), apolipoprotein A-(apoA-), apolipoprotein B (apoB) and clinicopathologic data were analyzed. Cox proportional hazards regression analyses and Kaplan-Meier method were performed to evaluate the overall survival (OS) and progression-free survival (PFS). ResultsMultivariable Cox regression analysis found that preoperative higher LDL-C level was signi cantly associated with worse OS (HR 2.088, 95% CI 1.052-4.147, p = 0.035), whereas higher HDL-C level showed signi cant association with better PFS (HR 0.491, 95% CI 0.247-0.975, p = 0.042). Further Kaplan-Meier survival analysis demonstrated that OS was longer for patients with low levels of LDL-C

Application of Dynamic and Static Light Scattering for Size and Shape Characterization of Small Extracellular Nanoparticles in Plasma and Ascites of Ovarian Cancer Patients

“…Altered lipid metabolism has emerged as another important feature of OC. Recent studies show that circulating lipid profile may be associated with the risk in OC [ 19 , 20 , 21 , 22 ]. Therefore, not only EVs, but also lipoproteins may be of interest in the OC prognosis and monitoring of the disease [ 8 , 11 , 12 , 19 , 20 , 21 , 22 ].…”

“…Recent studies show that circulating lipid profile may be associated with the risk in OC [ 19 , 20 , 21 , 22 ]. Therefore, not only EVs, but also lipoproteins may be of interest in the OC prognosis and monitoring of the disease [ 8 , 11 , 12 , 19 , 20 , 21 , 22 ]. EVs (sizes from 30 to ~1000 nm [ 23 ], which includes exosomes with sizes ~30–120 nm [ 11 , 24 ]), lipoproteins (sizes ~7–600 nm [ 25 ]), large protein complexes, and other particles in the overlapping size range, can be present in complex biological samples in different proportions.…”

Preoperative Serum Triglyceride to High-Density Lipoprotein Cholesterol Ratio Can Predict Prognosis in Non-Small Cell Lung Cancer: A Multicenter Retrospective Cohort Study

“…Meanwhile, Lv et al [ 30 ] revealed that the decrease in HDL-C level could indicate liver dysfunction caused by adjuvant chemotherapy in NSCLC, which partly supported the predictive significance of TG/HDL-C for patient prognosis. Additionally, prior research had also shown that lipid imbalances, including elevated TG levels or decreased HDL-C levels, enabled to predict a poorer prognosis in ovarian, colorectal, and breast cancer [ 17 , 31 , 32 ].…”

“…HDL-C can remove cholesterol from peripheral tissues and reverse-transport it to the liver, and thus can be regarded as a potent antioxidant and anti-inflammatory factor [ 16 ]. The metabolism of serum lipids and lipoproteins, such as TG and HDL-C, has a strong correlation to the nutritional status of patients (BMI), diet, and stressful metabolic states [ 17 ]. Reportedly, abnormalities in serum lipids and lipoproteins are strongly bound up with the development as well as the progression of cancer, suggesting that their potential roles in carcinogenesis and providing an innovative theoretical basis for anticancer treatment [ 18 , 19 , 20 , 21 ].…”

“…Reportedly, abnormalities in serum lipids and lipoproteins are strongly bound up with the development as well as the progression of cancer, suggesting that their potential roles in carcinogenesis and providing an innovative theoretical basis for anticancer treatment [ 18 , 19 , 20 , 21 ]. Until now, some studies have identified reduced serum HDL-C levels as one risk factor for ovarian cancer, hepatocellular, and nasopharyngeal carcinoma [ 17 , 22 , 23 ]. Conversely, Wang et al [ 24 ] found upregulated serum HDL-C as one risk factor for colorectal cancer.…”