Associations of semen quality with non-essential heavy metals in blood and seminal fluid: data from the Environment and Male Infertility (EMI) study in Lebanon

Sukhn, Carol; Awwad, Johnny; Ghantous, Akram; Zaatari, Ghazi

doi:10.1007/s10815-018-1236-z

Cited by 60 publications

(54 citation statements)

References 55 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Mercury has a negative role in fertility, both in men and women . In women, infertility is influenced by an imbalance of the female hormonal system due to Hg exposure.…”

Section: Mercury Exposure and Fertility: General Aspectsmentioning

confidence: 99%

“…The progesterone/oestrogen ratio changes in favour of oestrogen growth, which inhibits the release of LH‐luteinizing hormone. Thus, Hg may induce feminine infertility by increasing the prolactin secretion—analogous to the dopamine effect at the pituitary and midbrain level, with negative effects on galactopoiesis and female genitalia . Xenobiotics such as Hg, xenoestrogens, and synthetic oestrogens are endocrine disruptors present in most commercial foods, plastic products, tap water, plastic water glass, cosmetics, cleaning products, clothes detergents, paints, pesticides and insecticides .…”

Section: Mercury Exposure and Fertility: General Aspectsmentioning

confidence: 99%

“…Mercury has a negative role in fertility, both in men and women. 95,96 In women, infertility is influenced by an imbalance of the female hormonal system due to Hg exposure. The progesterone/oestrogen ratio changes in favour of oestrogen growth, which inhibits the release of LH-luteinizing hormone.…”

Section: Mercury Exposure and Fertilit Y: General Aspectsmentioning

confidence: 99%

“…Thus, Hg may induce feminine infertility by increasing the prolactin secretion-analogous to the dopamine effect at the pituitary and midbrain level, with negative effects on galactopoiesis and female genitalia. 19,96 Xenobiotics such as Hg, xenoestrogens, and synthetic oestrogens are endocrine disruptors present in most commercial foods, plastic products, tap water, plastic water glass, cosmetics, cleaning products, clothes detergents, paints, pesticides and insecticides. 97 Careful identification and reducing of endocrine disruptors, including Hg exposures in everyday life, are essential to protect reproductive capacity.…”

Section: Mercury Exposure and Fertilit Y: General Aspectsmentioning

confidence: 99%

See 3 more Smart Citations

Mercury exposure and its effects on fertility and pregnancy outcome

Bjørklund

Chirumbolo

Dadar

et al. 2019

Basic Clin Pharma Tox

View full text Add to dashboard Cite

Mercury (Hg), a highly toxic environmental pollutant, shows harmfulness which still represents a big concern for human health, including hazards to fertility and pregnancy outcome. Research has shown that Hg could induce impairments in the reproductive function, cellular deformation of the Leydig cells and the seminiferous tubules, and testicular degeneration as well as abnormal menstrual cycles. Some studies investigated spontaneous abortion and complicated fertility outcome due to occupational Hg exposure. Moreover, there is a relation between inhaled Hg vapour and reproductive outcome. This MiniReview evaluates the hypothesis that exposure to Hg may increase the risk of reduced fertility, spontaneous abortion and congenital deficits or abnormalities.

show abstract

“…Mercury has a negative role in fertility, both in men and women . In women, infertility is influenced by an imbalance of the female hormonal system due to Hg exposure.…”

Section: Mercury Exposure and Fertility: General Aspectsmentioning

confidence: 99%

Section: Mercury Exposure and Fertility: General Aspectsmentioning

confidence: 99%

Section: Mercury Exposure and Fertilit Y: General Aspectsmentioning

confidence: 99%

Section: Mercury Exposure and Fertilit Y: General Aspectsmentioning

confidence: 99%

See 2 more Smart Citations

Mercury exposure and its effects on fertility and pregnancy outcome

Bjørklund

Chirumbolo

Dadar

et al. 2019

Basic Clin Pharma Tox

View full text Add to dashboard Cite

show abstract

“…A study also found that follicle-stimulating hormone deficiency could affect male fertility 30 . Several studies focused on environmental chemical substances, including perfluoroalkyl compounds, Pb, Cd, Ba, and U, have demonstrated that these substances may adversely affect seminal quality [31][32][33] . To summarize, seminal plasma functions not only as a medium to carry, protect, and nourish sperm after ejaculation up to fertilization, but also modulates sperm functions 34 .…”

mentioning

confidence: 99%

Potential Pathogenic Bacteria in Seminal Microbiota of Patients with Different Types of Dysspermatism

Yang

Zhang

Xue

et al. 2020

Sci Rep

View full text Add to dashboard Cite

Human microbiota play an important role in the health of their human hosts. Recent studies have demonstrated that microbiota exist in seminal plasma. The current study aims to elucidate whether seminal microbiota exist in patients with different types of dysspermatism and whether bacterial biomarkers can be identified for them. A total of 159 study participants were recruited, including 22 patients with oligoasthenospermia, 58 patients with asthenospermia, 8 patients with azoospermia, 13 patients with oligospermia, and 58 matched healthy controls. Seminal microbiota composition was analyzed using 16S rRNA gene-based sequencing. The results showed that the composition of seminal microbiota of patients with dysspermatism differed from those of healthy controls. Comparison of the microbiota composition in semen samples from patients with different types of dysspermatism showed that microbiota in patients with asthenospermia and oligoasthenospermia were distinct from healthy controls in beta diversity (P < 0.05). Characteristic biomarkers, including Ureaplasma, Bacteroides, Anaerococcus, Finegoldia, Lactobacillus and Acinetobacter lwoffii, were identified based on LEfSe analysis. Inferred functional analysis based on seminal microbiome data further indicated the presence of potential pathogenic biomarkers in patients with asthenospermia and oligoasthenospermia. These results provided profiles of seminal microbiota exhibited in different types of dysspermatism, thus providing new insights into their pathogenesis. Human microbiota, with its diverse relationships-commensal, parasitic, mutualistic, and pathogenic-play an important role in human health. Recent studies have reported that microbiota exist in almost every part of human body-even in the endocrine niche, such as in tumors, blood, and synovial fluid 1-4. Advances in technology and new research have demonstrated that microbiota are found in seminal plasma, and play an important role in host homeostasis 5. It has been demonstrated that the presence of bacteria in sperm is associated with male infertility 6. Some bacteria in the urogenital tract may affect spermatogenesis and decrease sperm quality through various means, including decrease in sperm motility, deficiency in DNA integrity, and destruction of mitochondrial function 7. Escherichia coli, Mycoplasma genitalium, Ureaplasma urealyticum, Mycoplasma hominis, Staphylococcus aureus, and Chlamydia trachomatis are pathogens associated with male infertility 8-12. Several studies using high-throughput sequencing have demonstrated that seminal plasma has a bacterial community, which includes Lactobacillus, Pseudomonas, Prevotella, and Gardnerella, among others 13-19 .

show abstract

A new clustering model based on the seminal plasma/serum ratios of multiple trace element concentrations in male patients with subfertility

Tanaka,

Kojo,

Nagumo

et al. 2024

Reprod Medicine & Biology

View full text Add to dashboard Cite

PurposeTo investigate whether seminal plasma (SP)/serum ratios of multiple trace elements (TEs) can classify patients with male subfertility.MethodsSP/serum ratios of 20 TEs (lithium, sodium, magnesium, phosphorus, sulfur, potassium, calcium, manganese, iron, cobalt, copper, zinc, arsenic, selenium, rubidium, strontium, molybdenum, cesium, barium, and thallium) were calculated for healthy volunteers (n = 4) and those consulting for male subfertility (n = 245). Volunteer semen samples were collected by split ejaculation into early and subsequent fractions, and SP/serum ratio data were compared between fractions. The patients' SP/serum ratio data were used in an unsupervised clustering analysis and qualitatively compared with the data from the fractions of ejaculation from the volunteers. Semen quality parameters and pregnancy outcomes were compared between patient clusters.ResultsThe early fraction of volunteers was characterized by lower phosphorus and arsenic and 18 other higher TEs than the subsequent fraction. Cluster analysis classified patients into four distinct clusters, one sharing characteristics with the early fraction and another with the subsequent fraction. One cluster with the early fraction characteristics had significantly lower semen volume and higher pregnancy rates from spontaneous pregnancies or intrauterine insemination.ConclusionsClassification of patients based on SP/serum ratios of multiple TEs represents the dominance of fractions of ejaculation samples.

show abstract

Associations of semen quality with non-essential heavy metals in blood and seminal fluid: data from the Environment and Male Infertility (EMI) study in Lebanon

Abstract: Environmental exposures to Pb, Cd, Ba, and U appear to adversely influence sperm development in men. In non-occupationally exposed men, measurements of heavy metals in the seminal fluid may be more predictive of below-reference sperm quality parameters than in blood.

Cited by 60 publications

References 55 publications

Mercury exposure and its effects on fertility and pregnancy outcome

Mercury exposure and its effects on fertility and pregnancy outcome

Potential Pathogenic Bacteria in Seminal Microbiota of Patients with Different Types of Dysspermatism

A new clustering model based on the seminal plasma/serum ratios of multiple trace element concentrations in male patients with subfertility

Contact Info

Product

Resources

About