Associations of serum betaine with blood pressure and hypertension incidence in middle-aged and older adults: a prospective cohort study

Huang, Rong-Zhu; Ma, Jing-fei; Chen, Si; Chen, Yuming; Fang, Aiping; Lu, Xiaoting; Huang, Zihui; Zhu, H. L.; Huang, Bixia

doi:10.1039/d3fo00325f

Cited by 3 publications

(1 citation statement)

References 52 publications

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“…In a large population-based study of 7,074 mid-aged and elderly subjects, plasma betaine was reported to have a negative relationship with blood pressure level [29]. Similar results were observed in dialysis patients that circulating GB was negatively correlated with blood pressure [30]. As for the animal experiments, Rosas-Rodriguez et al reported that GB concentration increased during physiological cardiac hypertrophy induced by pregnancy in Sprague-Dawley rats, which was regulated by the enzyme betaine aldehyde dehydrogenase (BADH) to protect myocytes from hyperosmotic stress [31].…”

Section: Discussionsupporting

confidence: 56%

Inhibition of the STIM1/Orai1 Signaling Pathway by Glycine Betaine Mitigates Myocardial Hypertrophy in Spontaneous Hypertension Rats

Xiao,

Zhao,

Wang

et al. 2023

Cardiol Res

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Background: Spontaneous hypertension is a leading risk factor for cardiovascular diseases morbidity and mortality. Glycine betaine (GB) is a natural vitamin that has the potential to lower blood pressure. This work attempted to investigate the role and mechanisms of GB in spontaneous hypertension.Methods: Spontaneously hypertensive rats (SHRs) were administrated with 100, 200, or 400 mg/kg of GB by gavage or combined with by injection of lentivirus-mediated STIM1 overexpression vector. The heart rate (HR), systolic blood pressure (SBP), diastolic blood pressure (DBP) and heart weight/body weight (HW/BW) of rats were monitored. The pathological changes in myocardium were examined by hematoxylin and eosin staining and Masson staining. The expression of genes and proteins was detected by quantitative real-time PCR, western blotting, and immunohistochemistry.Results: GB at 200 and 400 mg/kg reduced the HR, SBP, DBP and HW/BW in SHRs. GB decreased the cross-sectional area and fibrotic area in the myocardium and downregulated the expression of atrial natriuretic peptide (ANP) and β-myosin heavy chain (β-MHC) in the myocardium of SHRs. It indicated that GB treatment effectively alleviated myocardial hypertrophy in SHRs. Additionally, GB treatment repressed the expression of stromal interaction molecule 1 (STIM1) and calcium release-activated calcium channel protein 1 (Orai1) in the myocardium of SHRs. STIM1 overexpression reversed GB treatment-mediated inhibition of myocardial hypertrophy in SHRs. Conclusions:In conclusion, GB repressed STIM1/Orai1 signaling pathway, which contributed to alleviating myocardial hypertrophy in SHRs. Thus, our study provides a theoretical basis for GB as an antihypertensive drug.

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Section: Discussionsupporting

confidence: 56%

Inhibition of the STIM1/Orai1 Signaling Pathway by Glycine Betaine Mitigates Myocardial Hypertrophy in Spontaneous Hypertension Rats

Xiao,

Zhao,

Wang

et al. 2023

Cardiol Res

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Randomized Trial of Nitrate-Replete Beetroot Juice on Blood Pressure in Hypertensive Adults with ADPKD

Sagar,

Elhindi,

Chau

et al. 2024

Kidney International Reports

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Deletion of Kcnj16 altered transcriptomic and metabolomic profiles of Dahl salt-sensitive rats

Xu,

Dissanayake,

Levchenko

et al. 2024

iScience

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Associations of serum betaine with blood pressure and hypertension incidence in middle-aged and older adults: a prospective cohort study

Abstract: The impact of betaine on the development of hypertension remains unclear, and prospective data are sparse. We aimed to investigate the association of serum betaine with repeated measurements of blood...

Cited by 3 publications

References 52 publications

Inhibition of the STIM1/Orai1 Signaling Pathway by Glycine Betaine Mitigates Myocardial Hypertrophy in Spontaneous Hypertension Rats

Inhibition of the STIM1/Orai1 Signaling Pathway by Glycine Betaine Mitigates Myocardial Hypertrophy in Spontaneous Hypertension Rats

Randomized Trial of Nitrate-Replete Beetroot Juice on Blood Pressure in Hypertensive Adults with ADPKD

Deletion of Kcnj16 altered transcriptomic and metabolomic profiles of Dahl salt-sensitive rats

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