Associations of Sex Steroids With Bone Maturation, Bone Mineral Density, Bone Geometry, and Body Composition: A Cross-Sectional Study in Healthy Male Adolescents

Vandewalle, Sara; Taes, Youri; Fiers, Tom; Toye, Kaatje; Caenegem, Eva Van; Roggen, Inge; Schepper, Jean De; Kaufman, Jean‐Marc

doi:10.1210/jc.2013-3887

Cited by 55 publications

(51 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…During puberty, men develop larger bone size partly due to the interplay of sex steroids with mechanical loading (6,44), and positive relationships of testosterone with periosteal circumference have been observed in pubertal boys and young men (5,6,45). The current results cannot confirm the previously reported larger radial cortical bone size and thinner cortex in trans men after 10 year of testosterone treatment compared with control women (9), although the observation time was probably too short to detect changes.…”

Section: Discussioncontrasting

confidence: 87%

“…Hence, quantitative computed tomography (QCT) and visualizing bone geometry can contribute for unraveling the interactions of sex steroid with trabecular and cortical bone. Sex steroids also influence bone size: men develop larger periosteal (outer) and endosteal (inner) circumference than women, partly due to the interplay of sex steroids, mechanical loading, and the growth hormone (GH)/ insulin-like growth factor 1 (IGF1)-axis during puberty (4,5,6). In adulthood, periosteal apposition continues, but at a slower rate in women than in men (7).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Body composition, bone turnover, and bone mass in trans men during testosterone treatment: 1-year follow-up data from a prospective case–controlled study (ENIGI)

Caenegem

Wierckx

Taes

et al. 2015

European Journal of Endocrinology

131

106

View full text Add to dashboard Cite

Purpose: To assess the evolution of body composition and bone metabolism in trans men during the first year of cross-sex hormonal therapy. Methods: In a prospective controlled study, we included 23 trans men (female-to-male trans persons) and 23 age-matched control women. In both groups, we examined grip strength (hand dynamometer), biochemical markers of bone turnover (C-terminal telopeptides of type 1 collagen (CTX) and procollagen 1 aminoterminal propeptide (P1NP)), total body fat and lean mass, and areal bone mineral density (aBMD) by dual-X-ray absorptiometry (DXA) and fat and muscle area at the forearm and calf, bone geometry, and volumetric bone mineral density (vBMD) by peripheral quantitative computed tomography (pQCT), before treatment and after 1 year of treatment with undecanoate (1000 mg i.m./12 weeks). Results: Before hormonal treatment, trans men had similar bone and body composition compared with control women. Testosterone treatment induced in trans men a gain in muscle mass (C10.4%) and strength and loss of fat mass (K9.7%) (all P!0.001) and increased the levels of P1NP and CTX (both P!0.01). Areal and volumetric bone parameters remained largely unchanged apart from a small increase in trabecular vBMD at the distal radius and in BMD at the total hip in trans men (PZ0.036 and PZ0.001 respectively). None of these changes were observed in the control group. Conclusions: Short-term testosterone treatment in trans men increased muscle mass and bone turnover. The latter may rather reflect an anabolic effect of testosterone treatment rather than bone loss.

show abstract

Section: Discussioncontrasting

confidence: 87%

Section: Introductionmentioning

confidence: 99%

Body composition, bone turnover, and bone mass in trans men during testosterone treatment: 1-year follow-up data from a prospective case–controlled study (ENIGI)

Caenegem

Wierckx

Taes

et al. 2015

European Journal of Endocrinology

131

106

View full text Add to dashboard Cite

show abstract

“…This explains why patients with aromatase deficiency resulting from inactivating mutation of the aromatase gene show undetectable levels of E 2 and, as a result, low BMD (9). Among male patients who are not aromatase deficient, aside from influencing bone maturation and peak bone mass acquisition, aromatase activity may also influence body composition, even at an early age (27,28). In a study among young males aged 6-19 years old, Vandewalle et al (27,28) reported that circulating E 2 was positively associated with skeletal maturation and areal and volumetric BMD.…”

Section: Discussionmentioning

confidence: 99%

“…Among male patients who are not aromatase deficient, aside from influencing bone maturation and peak bone mass acquisition, aromatase activity may also influence body composition, even at an early age (27,28). In a study among young males aged 6-19 years old, Vandewalle et al (27,28) reported that circulating E 2 was positively associated with skeletal maturation and areal and volumetric BMD. In addition, lean mass in these patients was also found to positively correlate with higher testosterone levels (27).…”

Section: Discussionmentioning

confidence: 99%

“…In a study among young males aged 6-19 years old, Vandewalle et al (27,28) reported that circulating E 2 was positively associated with skeletal maturation and areal and volumetric BMD. In addition, lean mass in these patients was also found to positively correlate with higher testosterone levels (27). Collectively the findings in that study suggest that in non-aromatase-deficient males, the influence of aromatase on male musculoskeletal health starts very early in life and extends to old age, and it likely impacts those who develop hypogonadism (4,29).…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

High aromatase activity in hypogonadal men is associated with higher spine bone mineral density, increased truncal fat and reduced lean mass

Aguirre

Colleluori

Fowler

et al. 2015

European Journal of Endocrinology

View full text Add to dashboard Cite

Objective: Because the aromatase enzyme catalyzes the conversion of testosterone to estradiol (E 2 ), the activity of this enzyme could be important in the musculoskeletal health of men with low testosterone. The objective of the present study is to determine the influence of aromatase activity on the bone mineral density (BMD) and body composition of patients with hypogonadism. Design: Cross-sectional study. Methods: The baseline data of 90 patients between 40 and 74 years old who participated in a genetic study of response to testosterone therapy in men with low testosterone (i.e., !300 ng/dl) were analyzed. BMD and body composition were measured by dual-energy X-ray absorptiometry. Serum testosterone was measured by automated immunoassay, E 2 was measured by ultrasensitive enzyme immunoassay, and sex hormone-binding globulin was measured by enzyme immunoassay. Results: Men in the highest tertile of E 2 to testosterone ratio (E 2 :T) had the highest spine BMD (P%0.037), highest truncal fat (PZ0.046), and lowest truncal lean body mass (PZ0.045). A similar pattern was observed in the upper extremities; that is, fat mass significantly increased (PZ0.047), whereas lean mass significantly decreased (PZ0.034) with increasing E 2 :T tertiles. Conclusion: The present findings suggest that in men with hypogonadism, aromatase activity could be an important determinant of musculoskeletal health. Men with high aromatase activity are able to maintain a higher BMD despite low circulating testosterone, but they have lower lean and higher truncal fat mass as compared to those with lower aromatase activity.

show abstract

Navigating Pubertal Goldilocks: The Optimal Pace for Hierarchical Brain Organization

Szakács,

Mutlu,

Balestrieri

et al. 2024

Advanced Science

View full text Add to dashboard Cite

Adolescence is a timed process with an onset, tempo, and duration. Nevertheless, the temporal dimension, especially the pace of maturation, remains an insufficiently studied aspect of developmental progression. The primary objective is to estimate the precise influence of pubertal maturational tempo on the configuration of associative brain regions. To this end, the connection between maturational stages and the level of hierarchical organization of large‐scale brain networks in 12‐13‐year‐old females is analyzed. Skeletal maturity is used as a proxy for pubertal progress. The degree of maturity is defined by the difference between bone age and chronological age. To assess the level of hierarchical organization in the brain, the temporal dynamic of closed eye resting state high‐density electroencephalography (EEG) in the alpha frequency range is analyzed. Different levels of hierarchical order are captured by the measured asymmetry in the directionality of information flow between different regions. The calculated EEG‐based entropy production of participant groups is then compared with accelerated, average, and decelerated maturity. Results indicate that an average maturational trajectory optimally aligns with cerebral hierarchical order, and both accelerated and decelerated timelines result in diminished cortical organization. This suggests that a “Goldilocks rule” of brain development is favoring a particular maturational tempo.

show abstract

Associations of Sex Steroids With Bone Maturation, Bone Mineral Density, Bone Geometry, and Body Composition: A Cross-Sectional Study in Healthy Male Adolescents

Abstract: Circulating E2 is positively associated with bone maturation and aBMD and vBMD and negatively with endosteal circumference in healthy boys, whereas T is a determinant of lean mass and bone size. These findings underscore the important role of E2 in skeletal development in boys.

Cited by 55 publications

References 34 publications

Body composition, bone turnover, and bone mass in trans men during testosterone treatment: 1-year follow-up data from a prospective case–controlled study (ENIGI)

Body composition, bone turnover, and bone mass in trans men during testosterone treatment: 1-year follow-up data from a prospective case–controlled study (ENIGI)

High aromatase activity in hypogonadal men is associated with higher spine bone mineral density, increased truncal fat and reduced lean mass

Navigating Pubertal Goldilocks: The Optimal Pace for Hierarchical Brain Organization

Contact Info

Product

Resources

About