Hanoi, Vietnam, has recently been facing several environmental issues including serious air pollution and climate changes, which have been reported as factors affecting child health. The purpose of my research is to evaluate the effect of atmospheric condition on children's health in Hanoi by examining how short-term changes in daily concentration of ambient air pollutants and weather condition affects the hospital admissions of children younger than 5 years old. The independent variables of the study include daily mean concentration of air pollutants such as particulate matter, nitrogen dioxide (NO2), sulphur dioxide (SO2), carbon monoxide (CO), ozone (O3) and daily meteorological data such as temperature and relative humidity, collected from the national automatic air quality stations. The dependent variables are the daily hospital admissions in children aged less than 5 and were collected from three hospitals in Hanoi. My thesis includes eight chapters which are Introduction (Chapter 1), Methods (Chapter 3), and four studies presented respectively in chapters 2, 4, 5 and 6; a Discussion (Chapter 7) and References (Chapter 8). My first study is a systematic review and meta-analysis on the relationship between air pollution and risk for a specific group of respiratory diseases: wheeze-associated disorders among children in Southeast Asia area. I searched the relevant computerized databases (PubMed, EMBASE, Web of Science, Scopus, and Cochrane library) for indexed publications up to July 2018. Finally, eight studies were qualified for performing a randomeffect meta-analysis to compute the pooled effect sizes. The results show that each increase of 10 µg/m 3 in concentrations of PM2.5 or PM1 was associated with 1-2% increase in risk of wheeze-associated disorders. Positive associations were found for PM10, SO2, NO2, NOx but no association was found for CO and O3. My study confirmed the strong effect of fine particulate matters on respiratory health and I recommend an updated meta-analysis should be done when more studies are available. A manuscript based on the results from this study has been published in Reviews on Environmental Health in the early of 2019 (Chapter 2). My second study examined the relationship between particulate air pollution and hospital admissions for respiratory diseases by using the time-stratified case-crossover design. The results confirmed that the daily hospital admissions for respiratory diseases among children