Associations of single nucleotide polymorphism rs17782313 in melanocortin 4 receptor gene with anthropometric indices in normal and obesity primary school children in Hanoi

Abstract

Melanocortin-4 receptor (MC4R) has roles in regulating food intake and energy balance. A number of studies have reported that variant rs17782313 is significantly associated with obesity in many populations. However, their contribution to obesity in the Vietnamese population is not fully described. The purpose of the present study was to evaluate the association of rs17782313 with anthropometric indices and obesity in the Vietnamese children population. A case-control study was conducted on 559 children aged 6-11 years (278 obese cases and 281 normal controls). The nutrition status of the children was classified using both criteria of International Obesity Task Force 2000 and World Health Organization 2007. The results showed that in normal group, the data of z score of weight for age was highest in CC genotype group and was lowest in TT genotype group (0.11 and -0.38 respectively, P=0.023). In obese group, the waist hip ratio was lowest in TT genotype group and the highest one was in CC genotype group (0.93 and 0.97 respectively, P=0.031). Our findings indicate that the variant rs17782313 near MC4R is likely to have an impact on the changing of weight and central obesity in the Vietnamese children.

Association of Genetic Variant in MC4R (rs17782313) Gene with Obesity and Other Health Behaviors among Selected Bangladeshi Population: A Population-based Case-control Study

“…Our present study found the association between MC4R gene SNP rs17782313 is related to an increased level of blood pressure, total cholesterol, triglycerides, and LDL-C which is mostly similar to other studies [32, 33]. This study also found that people carrying at least one C allele were at the condition of higher BMI and at increased risk of obesity and obesity-related metabolic disorders, which is similar to many other studies [34]. A genome-wide association study which was conducted in Caucasian people found some genetic variants associated with obesity and among them, rs17782313 of MC4R was the second strongest SNP associated with higher BMI and increased risk of having obesity [35].…”

“…In this study, the presence of homozygous allele CC and heterozygous allele CT was significantly associated with increased BMI, waist circumference, and hip circumference, which is similar to a Korean study that identified the variant rs17782313 was associated with higher BMI in people with minor allele C [36]. According to a case-control study by Le Thi Tuyet et al, in Vietnam, the anthropometric indices of the case group carrying the CC allele were higher than the TT allele and also the anthropometric indices were higher as compared with the control group [34]. Another study conducted on Chinese people and Tatar women also found a strong association between MC4R rs17782313 with increased BMI in subjects carrying CC and CT alleles [37,38].…”

Childhood Obesity as Interactions of Environmental and Genetic Factors: A Community – Based Study on Primary School Children of Hanoi, Vietnam

“…Analysis of the effects of each rs6499640, rs17782313, rs6548238 SNP on obesity in primary school children in Hanoi has been reported previously. It showed that variant in the SNP rs6499640 is related to the butt circumference in normal children 8 ; SNP rs17782313 is also related to the Z-score of weight/age in normal children as well as waist-to-hip ratio in obese children 9 when SNP rs6548238 affects obesity in both recessive and cumulative genetic models 7 . This study indicated that children having 2-3 risk alleles (of the studied SNPs) has an increased the risk of obesity by nearly 1.5 times compared to those with less than 2 risk alleles (p-value=0.041).…”

“…Family characteristics, eating habits, sedentary lifestyles, and total night sleeping times were reported as the factors related to childhood obesity in primary school children in our previous reports 5,6 . Also, in primary school children in Hanoi, it was discovered that the effects of the rs6265 in BDNF (Brain derived neurotrophic factor) 6 , the rs6548238 in Transmembrane protein 18 (TMEM18) on childhood obesity 7 as well as effect of the rs6499640 in FTO (Fat mass and obesity associated) 8 , and rs17782313 in MC4R (Melanocortin 4 receptor) attributed to some anthropometric features of children 9 .…”