Associations of TCF7L2 gene polymorphisms with the risk of diabetic nephropathy

Abstract

The aim of the study was to explore the correlation between rs7903146 and rs290487 polymorphisms in transcription factor 7-like 2 (TCF7L2) gene and diabetic nephropathy (DN) in Chinese Han population.Polymerase chain reaction–restriction fragment length polymorphism was used to determine genotypes of TCF7L2 polymorphisms in 90 patients with DN and 96 diabetes patients without DN. The linkage disequilibrium (LD) and haplotype analysis were performed with haploview software. Hardy–Weinberg equilibrium was assessed in the control group based on the genotype distributions of TCF7L2 polymorphisms. The genotype, allele, and haplotype distribution differences between the case and control groups were analyzed by chi-squared test, and odds ratio (OR) and 95% confidence interval (CI) were used to indicate the relative risk of DN.People carrying TT genotype of rs7903146 were more easily to be attacked by DN than CC genotype carriers (P = .02, OR = 4.26, 95% CI = 1.12–16.24). Meanwhile, T allele also showed 1.85 times risk to suffer from DN compared with C allele (OR = 1.85, 95% CI = 1.02–3.10). However, there was no significant difference in genotypes and alleles frequencies of rs290487 between 2 groups. The strong LD existed between the 2 single nucleotide polymorphisms and haplotype T–T (rs7903146–rs290487) increased the susceptibility to DN (OR = 2.63, 95% CI = 1.31–5.25).TCF7L2 rs7903146 polymorphism may be associated with the susceptibility to DN in Chinese Han population, but rs290487 is not. Additionally, haplotype is also a risk factor for DN.

In Silico Analysis of Possible Interaction between Host Genomic Transcription Factors (TFs) and Zika Virus (ZikaSPH2015) Strain with Combinatorial Gene Regulation; Virus Versus Host—The Game Reloaded

“…Finally, considering recent emerging evidences regarding the correlation between ZIKV and diabetes mellitus, our approach explains how the reduction of some TFs can be associated to pancreatic agenesis and/or disturbing its normal function. In particular PDX1 (Pancreas/Duodenum Homeobox Protein 1; OMIM 600733) is associated with early-onset of insulin dependent diabetes mellitus [ 45 ]; NKX6-1 (NK6, Homolog of Drosophila 1O; OMIM 602563) is implicated in development of insulin producing beta cells in the islets of Langerhans [ 46 ]; and TCF7L2 (Transcription Factor 7-Like 2; OMIM 602228) is involved in blood glucose homeostasis [ 47 ].…”

In Silico Analysis of Possible Interaction between Host Genomic Transcription Factors and Zika Virus (ZikaSPH2015) Strain with Combinatorial Gene Regulation; Virus Versus Host - The Game Reloaded

“…(Pancreas/Duodenum Homeobox Protein 1; OMIM 600733) is associated with earlyonset of insulin dependent diabetes mellitus [45], NKX6-1 (NK6, Homolog of Drosophila 1O; OMIM 602563) is implicated in development of insulin producing beta cells in the islets of Langerhans [46] and TCF7L2 (Transcription Factor 7-Like 2; OMIM 602228) is involved in blood glucose homeostasis [47].…”

Transcription factor 7-like 2 gene- smoking interaction on the risk of diabetic nephropathy in Chinese Han population

“…Previously, two studies conducted by Buraczynska et al [ 17 , 22 ] has verified that the rs7903146-T allele of TCF7L2 gene was significantly associated with DN, especially in the early stage of diabetes. Zhuang et al [ 18 ] carried out a case-control study in Chinese population, and found that TCF7L2 rs7903146 polymorphism had a significant impact on the susceptibility to DN in Chinese Han population, but rs290487 had no statistical association with DN. This was consistent with conclusions from Lewis et al [ 23 ], Hussain et al [ 12 ] and Sale et al [ 24 ], But Fu et al [ 25 ] concluded inconsistent results on relationship between TCF7L2 rs7903146 polymorphism and DN risk, in this study, just 248 DN patients were included in the analysis, so the limited sample size maybe the reason for inconsistent results between this study and our study.…”