Associations  of the Angiotensin Gene Polymorphism (Agt, Rs699)  With Systemic Hypertension and Its Risk Factors in Gornaya Shoria Inhabitants

Мулерова, Т. А.; Понасенко, А. В.; Цепокина, А. В.; Кузьмина, А. А.; Огарков, М. Ю.

doi:10.15829/1560-4071-2017-10-85-92

Cited by 2 publications

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References 19 publications

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“…Their association has been established among the Dagestan population (Saidov et al, 2017). Mulerova et al (2017) found out the differences in associative relationship of the genotypes of AGT gene with the risk factors of arterial hypertension depending on ethnicity in the inhabitants of Gornaya Shoria.…”

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confidence: 99%

Combination of Two Different C174t and C235t of the Angiotensinogen Gene Mutation and C677t Methylenetetrahydrofolate Reductase Gene Mutation in Patients With CVD in the Population of Azerbaijan

Guliyeva

2024

ABES

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We studied two mutations of C174T (Met174Tre) and C235T (Met235Tre) of the angiotensinogen gene and mutation C677T (Ala677Val) of the methylenetetrahydrofolate reductase gene, as well as their combinations among patients with cardiovascular diseases: coronary heart disease, myocardial infarction and hypertension, using a complex of modern molecular genetic diagnostic methods. A high frequency of these mutations has been established in the group of patients with severe forms of cardiovascular disorders. Homozygous and compound conditions were found in people with severe diseases. In particular, the heterozygous state of the mutation was found in people with moderate hypertension. It was also found that the presence of close blood relationship between the parents of patients with cardiovascular diseases increases the homozygotization of mutations of the genes AGT and MTGFR in probands. Consequently, such persons are susceptible to the disease or in other words, have an increased risk of developing diseases of the cardiovascular system. For the first time, the frequencies of these mutations in the Azerbaijani population have been determined, which are mostly consistent with the frequencies described in other populations of the world. The studied genetic markers are of interest as genes presumably associated with a wide range of cardiovascular diseases and can be used in further population and epidemiological studies. Therefore, the results of molecular genetic studies obtained by us in people with diseases of the cardiovascular system are of great practical importance. Timely prevention by detecting mutations of C174T, C235T of the AGT gene and C677T of the MTGFR gene in patients will allow doctors to carry out qualified treatment of cardiovascular diseases

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Section: Introductionmentioning

confidence: 99%

Combination of Two Different C174t and C235t of the Angiotensinogen Gene Mutation and C677t Methylenetetrahydrofolate Reductase Gene Mutation in Patients With CVD in the Population of Azerbaijan

Guliyeva

2024

ABES

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Interethnic Associations of Increased Heart Rate as a Factor of Cardiovascular Risk. Part 2: Genetic Markers

Мулерова

Ogarkov

2021

Evrazijskij kardiologičeskij žurnal

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Purpose. To study the genetic aspects of increased heart rate (HR) in representatives of various ethnic groups living in Mountain Shoria. Material and Methods. The study involved residents of the villages of Mountain Shoria aged 18 years and older. Included are 901 people – representatives of indigenous nationality (Shors), 408 people – of nonindigenous nationality. The groups did not differ by gender and age. The analysis was carried out depending on the increased level of heart rate (over 80 beats/min). Typing of polymorphic sites of the ACE (I/D, rs4340), ADRB1 (p.145A> G, Ser49Gly, rs1801252), ADRA2B (I/D, rs28365031), MTHFR (c.677C> T, Ala222Val, rs1801133) and NOS3 (VNTR, 4b/4a) was carried out using polymerase chain reaction. The association of different genotypes with heart rates above 80 beats/min was judged by the odds ratio in five inheritance models (codominant, dominant, recessive, overdominant and log-additive), and its 95% confidence interval was calculated. Results. Ethnic features of the prevalence of increased heart rate have been established depending on the polymorphism of candidate genes involved in the pathogenesis of arterial hypertension. The respondents of the indigenous ethnic group had a high probability of developing tachycardia determined by the carriage of the C/T genotype of the MTHFR gene according to an overdominant type of inheritance [OR = 2.46]. Allele D of the ACE gene determined the tendency to the development of this pathology according to the recessive type of inheritance [OR = 1.91]. However, among young people and men, carriage of a prognostically unfavorable D/D genotype of this gene was associated with a high risk of increased heart rate [OR = 3.34] and [OR = 4.62], respectively. In a cohort of non-indigenous nationality, the heterozygous genotype I/D of the ACE gene determined the likelihood of tachycardia by an overdominant type of inheritance [OR = 2.08]. Conclusions. Most epidemiological studies show a significant difference in the contribution of the studied polymorphisms to the appearance of increased heart rate for various ethnic groups. For a small population of Mountain Shoria, genetic features of the development of tachycardia have been established. In this regard, it is advisable to take into account national characteristics when determining individual risk, and apply personalization to correction programs.

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Associations of the Angiotensin Gene Polymorphism (Agt, Rs699) With Systemic Hypertension and Its Risk Factors in Gornaya Shoria Inhabitants

Cited by 2 publications

References 19 publications

Combination of Two Different C174t and C235t of the Angiotensinogen Gene Mutation and C677t Methylenetetrahydrofolate Reductase Gene Mutation in Patients With CVD in the Population of Azerbaijan

Combination of Two Different C174t and C235t of the Angiotensinogen Gene Mutation and C677t Methylenetetrahydrofolate Reductase Gene Mutation in Patients With CVD in the Population of Azerbaijan

Interethnic Associations of Increased Heart Rate as a Factor of Cardiovascular Risk. Part 2: Genetic Markers

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