Associations of the Mediterranean-Dietary Approaches to Stop Hypertension Intervention for Neurodegenerative Delay diet with cardiac remodelling in the community: the Framingham Heart Study

Abstract

Normal cardiac function is directly associated with the maintenance of cerebrovascular health. Whether the Mediterranean-Dietary Approach to Systolic Hypertension Intervention for Neurodegenerative Delay (MIND) diet, designed for the maintenance of neurocognitive health, is associated with cardiac remodeling is unknown. We evaluated 2512 Framingham Offspring Cohort participants who attended the 8th examination cycle and had available dietary and echocardiographic data (mean age 66 years; 55% women). Using multivariable regression, we related the cumulative MIND diet score (independent variable) to left ventricular (LV) ejection fraction, left atrial emptying fraction, LV mass (LVM), E/e’ ratio (dependent variables; primary), global longitudinal strain, global circumferential strain (GCS), mitral annular plane systolic excursion, longitudinal segmental synchrony, LV hypertrophy, and aortic root diameter (secondary). Adjusting for age, sex, and energy intake, higher cumulative MIND diet scores were associated with lower values of indices of LV diastolic (E/e’ ratio: logβ=-0.03) and systolic function (GCS: β=-0.04), and with higher values of LVM (logβ=0.02), all P≤0.01. We observed effect modification by age in the association between the cumulative MIND diet score and GCS. When we further adjusted for clinical risk factors, the associations of the cumulative MIND diet score with GCS in participants ≥66 years (β=-0.06, P=0.005) and LVM remained significant. In our community-based sample, relations between the cumulative MIND diet score and cardiac remodeling differ among indices of LV structure and function. Our results suggest that favorable associations between a higher cumulative MIND diet score and indices of LV function may be influenced by cardiometabolic and lifestyle risk factors.

Adherence to the MIND diet and the risk of cardiovascular disease in adults: a cohort study

“…On the contrary, an inverse association between the MIND diet and global circumferential strain (GCS) among subjects, aged >66 years was reported. 27 Our findings were in agreement with a new study that demonstrated an inverse association between higher adherence to the MIND diet and the odds of stroke (OR: 0.41; 95% CI: 0.18 to 0.94) in adults. 28 However, there are some differences between the latter study and the current study.…”

2022 Alzheimer's disease facts and figures

“…Physical activity [123][124][125][126][127][128][129][130][131][132][133][134][135] and MIND (Mediterranean-DASH Intervention for Neurodegenerative Delay) diets. [144][145][146] A systematic review 147 of the use of supplements, including vitamins C, D and E, omega-3 fatty acids and ginkgo biloba, found little to no benefit in preventing cognitive decline, MCI or Alzheimer's dementia.…”

“…A heart‐healthy diet emphasizes fruits, vegetables, whole grains, fish, chicken, nuts, legumes and healthy fats such as olive oil while limiting saturated fats, red meat and sugar. Examples of heart‐healthy diets are the Mediterranean, DASH (Dietary Approaches to Stop Hypertension) and MIND (Mediterranean‐DASH Intervention for Neurodegenerative Delay) diets 144–146 …”

The Influence of Nutrition on Intestinal Permeability and the Microbiome in Health and Disease

“…A future direction in the food industry can be functional food, which shapes the intestinal microbiota to a health-promoting composition. A varied, homemade, fruit- and vegetable-rich Mediterranean diet has similar health-promoting effects on the microbiota ( 179 – 181 ).…”