Associations of Tibial Lead Levels with BsmI Polymorphisms in the Vitamin D Receptor in Former Organolead Manufacturing Workers

Schwartz, Brian; Stewart, Walter F.; Kelsey, Karl T.; Simón, David; Park, Sunyeong; Links, Jonathan M.; Todd, Andrew C.

doi:10.2307/3454434

Cited by 19 publications

(24 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…First, genetic polymorphism of VDR has been associated with susceptibility to Pb and vitamin D deficiency in some studies; e.g. the VDR FokI (rs2228570) f genotype was associated with high 25(OH)D level and low blood Pb (22,23,(40)(41)(42) , which indicates that genetic features are not to be ignored. Second, some studies in animals have demonstrated that relationships among Pb, dietary Ca and vitamin D are complex and in some cases counterintuitive, and therefore are not predictable based solely on theoretical considerations (43)(44)(45) .…”

Section: Discussionmentioning

confidence: 99%

Association of 25-hydroxyvitamin D with Hb and lead in children: a Chinese population-based study

Liu

Shi

et al. 2013

Public Health Nutr.

View full text Add to dashboard Cite

Objective: To evaluate the prevalence of vitamin D deficiency and insufficiency, as well as their association with Hb and elevated blood lead levels (BLL) in children in China. Design: A cross-sectional and 1-year retrospective study. Setting: Department of Laboratory Medicine, West China Second University Hospital, Sichuan University, China. Subjects: Children aged from 6 months to 14 years living in south-west China who were taken to physical examinations (January-December 2011). Results: Of 1218 children included in the study, 25-hydroxyvitamin D (25(OH)D) concentration (mean 33?18 (SD 16?48) ng/ml) was deficient in 21?6 % and insufficient in 27?4 %, which were higher than the prevalence of both anaemia at 8?5 % and elevated BLL (Pb $ 10 mg/dl) at 1?8 %, but lower than mildly elevated BLL prevalence (5 mg/dl # Pb , 10 mg/dl) at 56?9 %. There was a negative correlation between 25(OH)D concentration and BLL (r 5 20?216, P , 0?001) while no significant relationship was found between 25(OH)D concentration and Hb (r 5 20?012, P . 0?05). After multivariable adjustment, the significant predictors of 25(OH)D deficiency and insufficiency were increasing child age especially between 8 and 14 years (OR 5 18?29; 95 % CI 10?14, 32?99; P , 0?001) and BLL (OR 5 1?01; 95 % CI 1?00, 1?02; P 5 0?045). Conclusions: The prevalence of 25(OH)D deficiency and insufficiency was much higher than that of anaemia or elevated BLL in south-west China, and associated with increasing age and BLL.

show abstract

Section: Discussionmentioning

confidence: 99%

Association of 25-hydroxyvitamin D with Hb and lead in children: a Chinese population-based study

Liu

Shi

et al. 2013

Public Health Nutr.

View full text Add to dashboard Cite

show abstract

“…We did not observe associations between the 3 lead biomarkers and VDR and APOE genotypes, in contrast to findings from occupational studies. 38,54 This may be because of lower concentrations of lead in all tissues in nonoccupational studies. However, in adjusted analysis of patella lead concentrations, there was evidence of effect modification by APOE genotype on relations of gender with patella lead concentrations.…”

Section: Differences By Agementioning

confidence: 99%

Gender and Race/Ethnicity Differences in Lead Dose Biomarkers

et al. 2008

Self Cite

View full text Add to dashboard Cite

Objectives. We sought to identify predictors of lead concentrations in the blood, tibias, and patellae of older adults and to describe differences by gender, race/ ethnicity, and other factors that can influence lead toxicokinetics and, thus modify health effects.Methods. Participants aged 50 to 70 years (N = 1140) were randomly identified from selected neighborhoods in Baltimore, Maryland. We measured lead concentrations by anodic stripping voltammetry (in blood) and 109 Cd-induced K-shell x-ray fluorescence (in bone). We used multiple linear regression to identify predictors of lead concentrations.Results. Mean (SD) lead concentrations in blood, tibias, and patellae were 3.5 (2.4) µg/dL, 18.9 (12.5) µg/g, and 6.8 (18.1) µg/g, respectively. Tibia concentrations were 29% higher in African Americans than in Whites (P < .01). We observed effect modification by race/ethnicity on the association of gender and physical activity to blood lead concentrations and by gender on the association of age to tibia lead concentrations. Patella lead concentrations differed by gender; apolipoprotein E genotype modified this relation.Conclusions. African Americans evidenced a prominent disparity in lifetime lead dose. Women may be at higher risk of release of lead from bone and consequent health effects because of increased bone demineralization with aging.

show abstract

“…Creatinine in urine was analyzed by the Sigma kit (St. Louis, Missouri, United States) (33). ALAD and VDR genotyping were completed for 798 exposed subjects and 795 referents by previously described methods (34)(35)(36)(37).…”

Section: Laboratory Methodsmentioning

confidence: 99%

Associations of lead biomarkers and delta-aminolevulinic acid dehydratase and vitamin D receptor genotypes with hematopoietic outcomes in Korean lead workers

Associations of Tibial Lead Levels with BsmI Polymorphisms in the Vitamin D Receptor in Former Organolead Manufacturing Workers

Cited by 19 publications

References 13 publications

Association of 25-hydroxyvitamin D with Hb and lead in children: a Chinese population-based study

Association of 25-hydroxyvitamin D with Hb and lead in children: a Chinese population-based study

Gender and Race/Ethnicity Differences in Lead Dose Biomarkers

Associations of lead biomarkers and delta-aminolevulinic acid dehydratase and vitamin D receptor genotypes with hematopoietic outcomes in Korean lead workers

Contact Info

Product

Resources

About