Associations of Triglycerides/High-Density Lipoprotein Cholesterol Ratio With Insulin Resistance, Impaired Glucose Tolerance, and Diabetes in American Adults at Different Vitamin D3 Levels

Liu, Yuanyuan; Gong, Renmin; Luo, Gang; Li, Jinxia; Li, Qidan; Yang, Liu; Wei, Xuedong

doi:10.3389/fendo.2021.735736

Cited by 12 publications

(5 citation statements)

References 33 publications

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“…It is noteworthy that this association between the three indicators and T2DM is not exactly similar in different population characteristics; for example, the TyG index had a linear 14 or U-shaped 15 relationship with T2DM in the Japanese population; it also showed a positive correlation in the white European population, 16 especially in participants with TyG index levels ≥8. 31. The relationship of the TG/HDL-C ratio change trajectory with the risk of T2DM in Chinese, especially in males with normal weight and younger than 60 years, was U-shaped, bell-shaped, and others; 17 the association between the TG/HDL-C ratio and incident T2DM is linear in Koreans 18 and nonlinear 19 in Chinese.…”

Section: Introductionmentioning

confidence: 96%

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Association of Non-Insulin-Based Insulin Resistance Indices with Risk of Incident Prediabetes and Diabetes in a Chinese Rural Population: A 12-Year Prospective Study

Li¹,

Xue²,

Dang³

et al. 2022

DMSO

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Three non-insulin-based insulin resistance (IR) indices, ie, triglyceride-glucose (TyG) index, triglyceride-to-high-density lipoprotein cholesterol (TG/HDL-C) ratio, and metabolic score for IR (METS-IR), were considered powerful and simplified alternatives for IR. However, evidence for the association between the three IR indices and incident type 2 diabetes mellitus (T2DM), especially impaired fasting glucose (IFG), remains limited. Therefore, this study aimed to explore the association among IR indices, incident IFG, and T2DM in a rural population cohort. Methods: We analyzed data from 2209 adults (aged 24-75 years) at baseline and from 1205 normoglycemic participants who were followed up. Cox proportional hazards models were used to evaluate the associations between the three indices and IFG or T2DM. Restricted cubic spline curves based on the Cox regression model were used to examine the association between baseline indices and incident T2DM. Results: For the baseline data, logistic analyses demonstrated that the TyG index, TG/HDL-C ratio, and METS-IR had a significantly positive correlation with IFG or T2DM after multivariable adjustment. During a median follow-up of 12.17 years, 157 incident cases of IFG and 97 incident cases of T2DM were noted. The risk of T2DM, but not IFG, was strongly associated with the baseline TyG index in the adjusted model, and participants with the TyG index in the third tertile had a higher risk of developing T2DM (adjusted hazards ratio, 2.84; 95% confidence intervals, 1.26-6.37; p for trend <0.001) than those in the lowest tertile (reference). Moreover, a linear relationship was observed between the TyG index and T2DM incidence. The TG/HDL-C ratio and METS-IR had no significant relationship with the risk of IFG or T2DM. Conclusion:The TyG index is more useful than the TG/HDL-C ratio and METS-IR in predicting T2DM in the normoglycemic population.

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Section: Introductionmentioning

confidence: 96%

“…27,28 Studies in Korean adults showed that increased TG/HDL-C was significantly associated with the incidence of T2DM after 5.9 years of follow-up, 29 and a similar result was found in Chinese Singaporeans. 30 In American adults, 31 the TG/HDL-C ratio is a risk factor for IR, IGT, and DM. This association is mainly due to its potential as a marker of IR.…”

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confidence: 99%

Association of Non-Insulin-Based Insulin Resistance Indices with Risk of Incident Prediabetes and Diabetes in a Chinese Rural Population: A 12-Year Prospective Study

Li¹,

Xue²,

Dang³

et al. 2022

DMSO

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“…For example, TG/HDL ratio of 3.0 predicts IR in non-Hispanic whites while a ratio of 2.0 predicts IR in non-Hispanic Blacks ( 25 ). To explore possible mechanisms for our findings on HbA1c and nutrition visits, we investigated changes in BMI z-score, BMI, body weight; and lipoprotein fractions, TC/HDL ( 26 ) and TG/HDL ( 27 ), as surrogate marker of IR ( 24 ), between the adherent and the non-adherent groups.…”

Section: Resultsmentioning

confidence: 99%

Prediabetes: Adherence to Nutrition Visits Decreases HbA1c in Children and Adolescents

et al. 2022

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BackgroundPrediabetes, the precursor of type 2 diabetes (T2D), is on the rise in the US, but the determinants of its progression are poorly characterized in youth.ObjectiveTo determine the impact of nutrition visits, as a surrogate marker of lifestyle modification, on the trajectory of prediabetes over a 4-year period.HypothesisAdherence to nutrition visits could reduce BMI and lower HbA1c.MethodsA 4-year retrospective study of 108 youth with prediabetes who were recommended to receive medical nutrition therapy every 3 months following their diagnosis. Subjects were divided into 2 groups: the non-adherent group who had ≤1 nutrition visit/year, and the adherent group with ≥2 nutrition visits/year.ResultsThere were 46 male subjects, mean age 12.4 ± 3.6y; and 62 female subjects, mean age, 13.3 ± 3.0y, p=0.2. The adherent group (n=44, 41.5%) had higher BMI z-scores, but similar values for HbA1c, metformin use, and racial/ethnic composition compared to the non-adherent group. Overall, 18(17.0%) subjects progressed to T2D in 4y and consisted of 14(22.6%) of the 62 non-adherent subjects and 4(9.1%) of the 44 adherent subjects. The non-adherent subjects progressed to T2D at a mean duration of 25.8 ± 12.6 months while the adherent subjects progressed at a mean duration of 34.9 ± 11.8 months. The hazard ratio of progression from prediabetes to T2D for the non-adherent versus adherent group was 3.88 (95%CI 1.26-11.98, p=0.02). The results remained significant after adjusting for age, sex, race/ethnicity, BMI, and metformin use.ConclusionAdherence to nutrition visits was associated with a 4-fold reduction in the likelihood to progress from prediabetes to T2D in US youth.

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“…The Homeostatic Model Assessment of insulin sensitivity (HOMA-IS) were calculated with the formula: 22.5 / [FPG (mmol/L) × FSI (μU/mL)]. HOMA-IR > 2.6 was used as a determination criterion of IR in this study [17]. The diagnosis of prediabetes was de ned as FPG ≥ 5.7 mmol/L and < 7.0 mmol/L, oral glucose tolerance test 2 h plasma glucose ≥ 7.8 mmol/L and < 11.0 mmol/L, HbA1c ≥ 5.7% and < 6.5%, and self-reported of prediabetes [18].…”

Section: Assessment Of Outcomesmentioning

confidence: 99%

Association between urinary albumin-to-creatinine ratio within the normal range and insulin resistance and prediabetes among US adults: a population-based study

Wu,

Yang,

Zhu

et al. 2024

Preprint

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Background Recent studies have shown that urine albumin-to-creatinine ratio (UACR) within the normal range is associated with increased risk of hypertension, diabetes, cardiovascular death and all-cause death. However, the relationship between normal range UACR and the prevalence of insulin resistance (IR) and prediabetes has not been explored. Methods The study included 14,208 US adults with normal range UACR values and without diabetes from the National Health and Nutrition Survey (1999-2018). The outcome variables included IR and prediabetes, as defined by the 2013 American Diabetes Association guidelines. The weighted multivariate linear regression, weighted multivariate logistic regression, restricted cubic spline (RCS) regression, and subgroup analysis were conducted to examine the relationship of UACR with IR and prediabetes. Results The weighted multivariate linear regression analysis showed that a 1-standard deviation (SD) increment in ln (UACR) was positively associated with fasting plasma glucose (FPG) (β = 0.02, 95% CI: 0.01, 0.04), glycosylated hemoglobin (β = 0.01, 95% CI: 0.00, 0.02), fasting serum insulin (FSI) (β = 0.50, 95% CI: 0.31, 0.68), and homeostasis model assessment of insulin resistance (HOMA-IR) (β = 0.14, 95% CI: 0.09, 0.19). The weighted multivariate logistic regression analysis revealed that a 1-SD increment in ln (UACR) was significantly associated with an increased prevalence of prediabetes (OR = 1.10, 95% CI: 1.04-1.15), but not with IR (OR = 1.05, 95% CI: 0.99-1.12). With the lowest quartile of UACR as a reference, ORs (95% CIs)for IR in the second, third, and fourth quartiles were 1.10 (0.86, 1.15), 1.15 (0.98, 1.33), and 1.12 (0.95, 1.32), respectively, and ORs (95% CIs) for prediabetes were 1.35 (1.19, 1.52), 1.32 (1.14, 1.53), and 1.44 (1.24, 1.66), respectively. Subgroup analysis indicated that smoking had a significant impact on the association between UACR and prediabetes. The association between UACR and prediabetes was more significant in smokers than in non-smokers (P for interaction = 0.03). RCS regression analysis revealed a non-linear positive dose-response association between UACR and indicators of diabetes. Conclusion Elevated UACR, even within the normal range, was positively associated with indicators of diabetes and increased prevalence of prediabetes among US adults. Smoking had a significant impact on the association between UACR and prediabetes, with a more pronounced association observed among smokers.

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Associations of Triglycerides/High-Density Lipoprotein Cholesterol Ratio With Insulin Resistance, Impaired Glucose Tolerance, and Diabetes in American Adults at Different Vitamin D3 Levels

Cited by 12 publications

References 33 publications

Association of Non-Insulin-Based Insulin Resistance Indices with Risk of Incident Prediabetes and Diabetes in a Chinese Rural Population: A 12-Year Prospective Study

Association of Non-Insulin-Based Insulin Resistance Indices with Risk of Incident Prediabetes and Diabetes in a Chinese Rural Population: A 12-Year Prospective Study

Prediabetes: Adherence to Nutrition Visits Decreases HbA1c in Children and Adolescents

Association between urinary albumin-to-creatinine ratio within the normal range and insulin resistance and prediabetes among US adults: a population-based study

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