Associations of vitamin B6 turnover rate with the risk of cardiovascular and all-cause mortality in hypertensive adults

Cui, Qianwei; Zhu, Xu; Guan, Gongchang; Hui, Rutai; Zhu, Lihua; Wang, Junkui; Zhao, Jingsha

doi:10.1016/j.numecd.2023.03.017

Cited by 3 publications

(4 citation statements)

References 39 publications

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“…Qianwei Cui et al. observed inverse associations between vitamin B6 conversion rates and the risk of cardiovascular and all-cause mortality in hypertensive adults ( 35 ). These studies support our findings.…”

Section: Discussionmentioning

confidence: 99%

Associations of serum vitamin B6 status with the risks of cardiovascular, cancer, and all-cause mortality in the elderly

Wang,

Huang,

Xue

et al. 2024

Front. Immunol.

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BackgroundThere are few studies investigating the relationship between serum vitamin B6 and mortality risk in the elderly. This study hereby evaluated the associations between biomarkers of serum vitamin B6 status and cardiovascular, cancer, and all-cause mortality risks in the elderly.MethodsOur study included a total of 4,881 participants aged 60 years or older from the National Health and Nutrition Examination Survey (NHANES) 2005-2010. Serum vitamin B6 status was estimated based on levels of pyridoxal 5’-phosphate (PLP), 4-pyridoxic acid (4-PA), and vitamin B6 turnover rate (4-PA/PLP) detected by high-performance liquid chromatography. Survival status and corresponding causes of death were matched through the National Death Index records through December 31, 2019. Multivariate Cox regression model was adopted to assess the relationships between serum vitamin B6 status and the risk of mortality.ResultsDuring a median follow-up period of 10.33 years, 507 cardiovascular deaths, 426 cancer deaths, and 1995 all-cause deaths were recorded, respectively. In the multivariate-adjusted Cox model, the hazard ratios (HRs) and 95% confidence intervals (CIs) for the highest versus the lowest quartiles of PLP, 4-PA, and 4-PA/PLP were 0.70(0.54-0.90), 1.33(0.88-2.02), and 2.01(1.41-2.79) for cardiovascular mortality, 0.73(0.52-1.02), 1.05(0.71-1.57), and 1.95(1.25-3.05) for cancer mortality, and 0.62(0.53-0.74), 1.05(0.82-1.34), and 2.29(1.87-2.79) for all-cause mortality, respectively.ConclusionOur study found that lower serum PLP levels were associated with increased risks of cardiovascular and all-cause mortality among the elderly population. And higher vitamin B6 turnover rate was associated with increased risks of cardiovascular, cancer, and all-cause mortality.

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Section: Discussionmentioning

confidence: 99%

Associations of serum vitamin B6 status with the risks of cardiovascular, cancer, and all-cause mortality in the elderly

Wang,

Huang,

Xue

et al. 2024

Front. Immunol.

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“…Cui et al [42] IL-6 = interleukin-6; RTR = renal transplant recipients; (+) significant and (−) non-significant association between B6 status and all-cause mortality. The studies of references [22,32] did not show results for all-cause mortality.…”

Section: Epidemiological Studies 21 Methods Of Literature Surveymentioning

confidence: 99%

“…A summary of findings from fourteen studies examining the relationship between B6 status and all-cause mortality in patients with various diseases is presented in Table 3 . Among the fourteen studies, nine reported a significant association [ 31 , 34 , 36 , 37 , 38 , 39 , 40 , 41 , 42 ]. Four studies [ 29 , 30 , 33 , 35 ] indicated no association.…”

Section: Epidemiological Studiesmentioning

confidence: 99%

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Relationship of Low Vitamin B6 Status with Sarcopenia, Frailty, and Mortality: A Narrative Review

Kato,

Kimoto,

Zhang

et al. 2024

Nutrients

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Marginal vitamin B6 (B6) deficiency is a widespread global concern. Inadequate B6 levels have been linked to an increased risk of age-related chronic diseases such as cardiovascular diseases and cancers. In recent years, the growing concern over sarcopenia (the age-related loss of muscle mass and strength) and frailty (a decline in physiological resilience and increased vulnerability associated with aging) is particularly relevant due to the emergence of super-aged societies in developed countries. Notably, among the thirty-one studies included in this review, twenty-five showed a significant association of B6 status with sarcopenia, frailty, and all-cause mortality in adults (p < 0.05), while six showed no association. Emerging studies have suggested novel mechanisms underlying this association. These mechanisms involve P2X7 receptor-mediated NLRP3 inflammasome signaling, AMPK signaling, PD-L1 signaling, and satellite cell-mediated myogenesis. Furthermore, the modulation of PLP-dependent enzymes due to B6 deficiency is associated with impaired metabolic processes, affecting energy utilization, imidazole peptide production, and hydrogen sulfide production, as well as the kynurenine pathway, all of which play vital roles in skeletal muscle health and pathophysiology. This narrative review provides an up-to-date assessment of our current understanding of the potential role of nutritional B6 status in combating sarcopenia, frailty, and mortality.

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Association between the dietary inflammatory index and all-cause and cardiovascular mortality in patients with atherosclerotic cardiovascular disease

Yang,

Miao,

et al. 2024

Nutrition, Metabolism and Cardiovascular Diseases

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Associations of vitamin B6 turnover rate with the risk of cardiovascular and all-cause mortality in hypertensive adults

Cited by 3 publications

References 39 publications

Associations of serum vitamin B6 status with the risks of cardiovascular, cancer, and all-cause mortality in the elderly

Associations of serum vitamin B6 status with the risks of cardiovascular, cancer, and all-cause mortality in the elderly

Relationship of Low Vitamin B6 Status with Sarcopenia, Frailty, and Mortality: A Narrative Review

Association between the dietary inflammatory index and all-cause and cardiovascular mortality in patients with atherosclerotic cardiovascular disease

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