Associations of Vitamin D Level and Glucoregulatory Parameters in Type 2 Diabetes Mellitus

Abstract

Vitamin D is known to affect the functions of pancreatic beta cells, but the effects of vitamin D deficiency on glucoregulatory mechanisms are still inconclusive. The aim of this study was to link vitamin D levels with parameters of insulin resistance and insulin secretion. The study included 70 male and female participants, 40 newly diagnosed patients with type 2 diabetes mellitus (T2DM) and 30 healthy controls. All participants were tested for fasting glucose, hemoglobin A1c, fasting insulin, vitamin D levels, and the HOMA indexes were calculated using HOMA2 calculator. Fasting glucose levels, insulinemia, hemoglobin A1c levels and HOMA IR were all significantly higher in the diabetic group (p<0.001), while vitamin D levels and HOMA S index were significantly lower (p<0.001). HOMA-B values did not differ between the two groups (p=0.31). Vitamin D levels moderately correlated with HOMA S and HOMA B indexes (r=0.466, p<0.001; r=0.394, p<0.001, respectively), whereas a negative correlation was found between vitamin D levels and HOMA IR (r=−0.285; p<0.001). Multiple regression analysis showed that vitamin D levels significantly predicted the values of HOMA B index (p=0.001), but they had no predictive value on HOMA IR (p=0.26). In conclusion, the group of newly diagnosed patients with T2DM showed significantly lower vitamin D values compared to the healthy control group. The connection between vitamin D, glucose levels, hemoglobin A1c and insulin secretion index underlines the role of this vitamin in glucoregulation.