Associations with Meibomian Gland Atrophy in Daily Contact Lens Wearers

Pucker, Andrew D.; Jones‐Jordan, Lisa A.; Li, Wing; Kwan, Justin; Lin, Meng C.; Sickenberger, Wolfgang; Marx, Sebastian; Srinivasan, Sruthi; Jones, Lyndon

doi:10.1097/opx.0000000000000650

Cited by 45 publications

(62 citation statements)

References 36 publications

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“…Pucker et al found no association between the area of meibomian gland atrophy and contact lens history, neither with subjective assessment nor with a semi-automatic approach, when using an univariate model. 30 Nichols and Sinnott did not report any structural changes in the glands of patients wearing rigid gas permeable or soft contact lenses. 31 In this study, all the analysed morphological characteristics of meibomian glands were worse initially for subjects with a previous history of contact lens wear.…”

Section: Discussionmentioning

confidence: 91%

Meibomian glands structure in daily disposable soft contact lens wearers: a one‐year follow‐up study

Llorens‐Quintana

Garaszczuk

Szczesna‐Iskander

2020

Ophthalmic Physiologic Optic

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Purpose To assess the impact of daily disposable soft contact lenses on meibomian gland morphology over a period of 12 months. Methods Forty‐one subjects (33 experienced and 8 neophytes) were fitted with either silicone‐hydrogel or hydrogel daily contact lenses. The study protocol included four visits: baseline, day‐2 for contact lens fit and follow‐up measurements, as well as after 6 and 12 months of lens wear. Non‐contact infrared meibography images were acquired with Keratograph 5M topographer (http://www.oculus.de) and analysed with an automated method, which objectively estimates the area of gland atrophy, gland length and width, number of glands and gland irregularity. Protocol at follow‐up visits also included symptom assessment with the Ocular Surface Disease Index and clinical assessment of tear meniscus height, bulbar and limbal redness, tear osmolarity, non‐invasive fluorescein break‐up time and ocular surface staining. Results Statistically significant differences were found in gland atrophy (p = 0.02) and length (p = 0.008) between experienced and novel contact lens wearers at the baseline visit. Changes over time (after 6 and 12 months) were found in gland atrophy (p = 0.02) and the number of glands (p = 0.01) in subjects fitted with hydrogel contact lenses. Changes in gland atrophy between baseline and 12 months of lens wear correlated with changes in corneal staining (r = 0.40, p = 0.03) and fluorescein break‐up time in subjects fitted with silicone‐hydrogel lenses (r = 1−0.43, p = 0.02). Conclusions Contact lens wear impacts meibomian gland morphology. However, changes are either long‐term or characteristic to an early phase. Subjects with no history of contact lens wear exhibit better meibomian gland condition than experienced wearers. During one year of contact lens wear, meibomian gland morphology changes in subjects wearing daily disposable hydrogel lenses.

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Section: Discussionmentioning

confidence: 91%

Meibomian glands structure in daily disposable soft contact lens wearers: a one‐year follow‐up study

Llorens‐Quintana

Garaszczuk

Szczesna‐Iskander

2020

Ophthalmic Physiologic Optic

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“…Many studies have shown that contact lens wear negatively affects the condition of meibomian glands, [30][31][32][33][34][35][36][37][38] although some have found no relation between lens wear and gland condition. [39][40][41] In wearers of rigid gas-permeable lenses, gland changes were detected at the temporal side in the upper eyelid, whereas wearers of soft contact lenses manifested linear shortening at the distal side in the lower eyelid ( Fig. 3).…”

Section: Contact Lens Wearmentioning

confidence: 99%

Meibography: A Japanese Perspective

Arita

2018

Invest. Ophthalmol. Vis. Sci.

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Meibography allows observation of meibomian glands in an objective and repeatable manner. Original meibography systems were invasive and not readily adopted by ophthalmology clinics. The development of noncontact infrared meibography allowed the rapid and noninvasive observation of meibomian glands, and such systems have now been widely adopted for standard examinations in dry eye clinics. Noncontact meibography has also spurred research into meibomian glands and has been applied to evaluation of their structure and status in various ocular surface diseases. Although the images obtained by meibography are objective and repeatable, the interpretation of these images is subjective, with the relationship between image features and actual gland structure and composition remaining unclear. Additional clinical and basic research with regard to the interpretation of meibography images is thus necessary. Future improvements to meibography will likely provide new insights into the pathophysiology of meibomian gland diseases as well as enhance its contribution to the diagnosis and evaluation of treatments for such diseases.

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“…SL fogging may be made proportionally worse by fitting SL with a higher central corneal clearance, and it is a problem that can typically only be alleviated by the removing, cleaning, and reapplying of the lens [1,7,15,16]. While the community has begun to characterize SL fogging, there is still a lack of information related to other commonly reported minor CL complications like ocular redness and visual blur [17,18]. Therefore, the purpose of this study was to conduct a survey at an international specialty CL conference.…”

Section: Introductionmentioning

confidence: 99%