Associative Cortex Features in the First Olfactory Brain Relay Station

Doucette, Wilder; Gire, David H.; Whitesell, Jennifer D.; Carmean, Vanessa; Lucero, Mary T.; Restrepo, Diego

doi:10.1016/j.neuron.2011.02.024

Cited by 156 publications

(193 citation statements)

References 59 publications

(104 reference statements)

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“…The authors suggest that this is an easily understood and implemented population temporal code, the decoding of which simply requires downstream coincidence detectors, connected to decision-making networks, that take input from both members of the neuron pair. Doucette et al (2001) then found that the SS rate is modulated by noradrenergic input to the bulb. In this way the SS code can signal the reinforcement significance of the stimulus.…”

Section: The Saliency Detection Hypothesismentioning

confidence: 98%

“…This detailed arrangement suggested to Rahman and Baizer (2007) that many claustral neurons make extensive inter cell type and intraclaustral connections. These connections between the GABAergic network and the INs in the CDNN may serve to allow many modulatory functions as to the fine tuning of the CDNN by neuromodulators, such as norepinephrine and others (Doucette et al, 2001).…”

Section: The Role Of Gabaergic Interneuronsmentioning

confidence: 99%

“…Doucette et al (2001) suggest another account of what information synchronized spikes may be carrying. This leads to a wider concept of what the function of the postulated spike burst synchrony detection mechanism of the claustrum might be.…”

Section: The Saliency Detection Hypothesismentioning

confidence: 99%

“…This leads to a wider concept of what the function of the postulated spike burst synchrony detection mechanism of the claustrum might be. Doucette et al (2001) studied spike-timing codes in the olfactory system and came up with a challenging result. They report that the number of synchronous spikes (SS) fired by pairs of olfactory bulbar neurons signals, not stimulus properties, but the salient information of whether the odor is associated with reward or not.…”

Section: The Saliency Detection Hypothesismentioning

confidence: 99%

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Hypotheses Relating to the Function of the Claustrum

2014

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Section: The Saliency Detection Hypothesismentioning

confidence: 98%

Section: The Role Of Gabaergic Interneuronsmentioning

confidence: 99%

Section: The Saliency Detection Hypothesismentioning

confidence: 99%

Section: The Saliency Detection Hypothesismentioning

confidence: 99%

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Hypotheses Relating to the Function of the Claustrum

2014

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“…Memory for the conditioning odor is likely to be represented as a stronger, sharper, and more synchronized mitral cell output from the olfactory bulb. An increased output synchrony has recently been shown to indicate encoded reward (Doucette et al 2011). g frequency enhancement by the a 2 -adrenoceptor may confer the reward signature in odor preference learning.…”

mentioning

confidence: 99%

Olfactory bulb α₂-adrenoceptor activation promotes rat pup odor-preference learning via a cAMP-independent mechanism

2012

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In this study, three lines of evidence suggest a role for a 2 -adrenoreceptors in rat pup odor-preference learning: olfactory bulb infusions of the a 2 -antagonist, yohimbine, prevents learning; the a 2 -agonist, clonidine, paired with odor, induces learning; and subthreshold clonidine paired with subthreshold b-adrenoceptor activation also recruits learning. Increased mitral cell layer pCREB occurs with clonidine-infusion, but cAMP is not increased. Similar results using a GABAa-antagonist suggest that disinhibition may support clonidine-induced learning. We suggest that norepinephrine can act through multiple bulbar adrenoceptor subtypes to induce odor learning and that cAMP-dependent, as well as cAMP-independent, signals may act as unconditioned stimuli.Odor-preference learning in the week-old rat pup occurs when a novel odor (conditioned stimulus, CS) is paired with activation of the noradrenergic locus coeruleus. The locus coeruleus is activated by the range of stimuli that can induce odor-preference learning including stroking (Sullivan and Leon 1986;McLean et al. 1993) and feeding (Johanson and Teicher 1980;Kucharski and Hall 1987;Sullivan and Hall 1988), all of which serve as unconditioned stimuli (US). Even rough maternal handling mimicked by mild shocks will engage odor-preference learning (Camp and Rudy 1988;Sullivan et al. 2000a). Odor-preference learning enables rat pups to locate the dam at a period when visual and auditory input is minimal. Odor paired with the activation of b-adrenoceptors in the olfactory bulb is sufficient to induce odor learning, while a bulbar b-adrenoceptor antagonist prevents odorpreference learning (Sullivan et al. 2000b). Thus, the olfactory bulb appears to be the critical site for the CS-US pairing, and the likely location of the odor memory.However, in addition to b-adrenoceptors, which induce odor learning via activation of the cAMP/PKA/CREB cascade (McLean et al. 1999; Yuan et al. 2003a,b;Cui et al. 2007;Grimes et al. 2012), there are bulbar a-adrenoceptors likely to be engaged by norepinephrine (NE) release. Recently, studies of a 2 -adrenoceptor activation in the olfactory bulb in vitro have revealed receptor effects that could promote odor learning (Nai et al. 2010;Pandipati et al. 2010). In particular, the a 2 -adrenoceptor agonist, clonidine, has been shown to decrease granule cell excitability (Nai et al. 2010), releasing the odor-encoding mitral cells from tonic inhibition, and to promote olfactory bulb synchrony at g EEG frequencies (Pandipati et al. 2010). These studies predict a role for a 2 -adrenoceptor activation in odor-preference learning.The present experiments assess the role of bulbar a 2 -adrenoceptors in rat pup odor-preference learning.In all experiments, drugs were infused into the olfactory bulbs on postnatal day (PND) 6. Day of birth was considered PND 0. Sprague-Dawley rat pups of both sexes were used and litters were culled to 12 pups on PND 1. Dams were maintained under a 12-h reverse light/dark cycle at 22˚C in polycarbonate cages with ad l...

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