1983
DOI: 10.1073/pnas.80.23.7347
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Associative long-term potentiation in hippocampal slices.

Abstract: Interactions between two excitatory monosynaptic inputs to hippocampal neurons of the CAI region were examined in the in vitro slice. By adjusting the strengths of the electrical stimuli delivered to the two input pathways, one was made to generate a weak and the other a strong synaptic response. Simultaneous tetanie stimulation of'both input pathways resulted in a subsequent long-term enhanced synaptic efficacy in the weak input under conditions in which the same tetanic stimulation of either input alone fail… Show more

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Cited by 230 publications
(110 citation statements)
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“…Associativity of LTP is defined by concomitant activation of two inputs to the same neuron. This form of LTP was first discovered in the hippocampus of mice (Barrionuevo and Brown, 1983). By now, associative LTP has also been demonstrated in a variety of neocortical networks.…”
Section: Introductionmentioning
confidence: 99%
“…Associativity of LTP is defined by concomitant activation of two inputs to the same neuron. This form of LTP was first discovered in the hippocampus of mice (Barrionuevo and Brown, 1983). By now, associative LTP has also been demonstrated in a variety of neocortical networks.…”
Section: Introductionmentioning
confidence: 99%
“…Such effects have been observed also in the presence of GABA antagonists, suggesting that they can be unrelated to changes in inhibitory pathways (Barrionuevo and Brown, 1983;Wigstrijm and Gustafsson, 1983~). These results suggest that the induction of LLP is controlled by a combination of pre-and postsynaptic activity, a notion also supported by the finding that the generation of LLP is greatly facilitated following reduction of inhibition (Wigstram andGustafsson, 1983a, b, 1985b).…”
Section: Discussionmentioning
confidence: 99%
“…It is well known that neuronal synchronization is a critical factor in synaptic plasticity. Robust synchrony between presynaptic and postsynaptic neurons enhances, whereas a lack of synchrony decreases, synaptic efficacy (Lynch et al, 1977;McNaughton et al, 1978;Levy and Steward, 1979;Barrionuevo and Brown, 1983;Bramham and Srebro, 1987;Stanton and Sejnowski, 1989;Dan and Poo, 2004).…”
Section: Functional Relevance Of the Hippocampal Somentioning
confidence: 99%