Assortment of Tachystatin B of Tachypleus tridentatus as a Stable Scaffold in Antifungal Peptide Design

Senthilkum, B.; Rajasekaran, R.

doi:10.3923/tb.2016.14.22

Trends in Bioinformatics

2016

DOI: 10.3923/tb.2016.14.22

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Assortment of Tachystatin B of Tachypleus tridentatus as a Stable Scaffold in Antifungal Peptide Design

B. Senthilkum¹,

R. Rajasekaran²

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Cited by 3 publications

References 30 publications

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The structural and functional reliability of Circulins of Chassalia parvifolia for peptide therapeutic scaffolding

Balaraman

Rajasekaran

2018

J of Cellular Biochemistry

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Computational methods have refined the mode of peptide drug designing to a new plateau recently. Circulin, a 30 residue natural plant polypeptide acts as a plant defensive peptide. Additional to its antimicrobial activity it also possesses an inhibitory cytopathic effect on the replication of human immunodeficiency virus (HIV). Stable Circulin can be a functionally able template for scaffolding peptide based drugs. Hence, structural stability of Chassalia parvifolia, Circulin A (1BH4), and Circulin B (2ERI) was computationally investigated. From this analysis, the stability favored toward Circulin B which was supported by various parameters such as intra-molecular interactions (61), secondary structure, hydrophobicity (67.34%), root mean square deviation (2.64Å), root mean square fluctuation (0.08Å), radius of gyration (8.96Å), ovality (3.49), angular deviation (73.6%), surface area (both polar and non-polar), hydrogen bond distribution (11.94), and disulphide bond distances. Further, the functional activity calculated in terms of membrane associated free energy (-4.10 kcal/mol) also favored Circulin B. Hence, Circulin B could be proposed as the best template for scaffolding antimicrobial as well as antiviral (HIV) peptide based drug design. The obtained computational data can aid experimental biologists to successfully produce stable therapeutic peptides from natural resources reducing erroneous wastage of monetary sources and time.

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The structural and functional reliability of Circulins of Chassalia parvifolia for peptide therapeutic scaffolding

Balaraman

Rajasekaran

2018

J of Cellular Biochemistry

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Structural Stability Among Hybrid Antimicrobial Peptide Cecropin A(1–8)–Magainin 2(1–12) and Its Analogues: A Computational Approach

et al. 2017

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Biomolecules of the Horseshoe Crab’s Hemolymph: Components of an Ancient Defensive Mechanism and Its Impact on the Pharmaceutical and Biomedical Industry

Ashrafuzzaman¹,

Razu²,

Showva³

et al. 2022

Cellular Microbiology

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Without adaptive immunity, invertebrates have evolved innate immune systems that react to antigens on the surfaces of pathogens. These defense mechanisms are included in horseshoe crab hemocytes’ cellular responses to pathogens. Secretory granules, large (L) and small (S), are found on hemocytes. Once the invasion of pathogens is present, these granules release their contents through exocytosis. Recent data in biochemistry and immunology on the granular constituents of granule-specific proteins are stored in large and small granules which are involved in the cell-mediated immune response. L-granules contain most clotting proteins, which are necessary for hemolymph coagulation. They also include tachylectins; protease inhibitors, such as cystatin and serpins; and anti-lipopolysaccharide (LPS) factors, which bind to LPS and agglutinate bacteria. Big defensin, tachycitin, tachystatin, and tachyplesins are some of the essential cysteine-rich proteins in S-granules. These granules also contain tachycitin and tachystatins, which can agglutinate bacteria. These proteins in granules and hemolymph act synergistically to fight infections. These biomolecules are antimicrobial and antibacterial, enabling them to be drug resistant. This review is aimed at explaining the biomolecules identified in the horseshoe crab’s hemolymph and their application scopes in the pharmaceutical and biotechnology sectors.

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Assortment of Tachystatin B of Tachypleus tridentatus as a Stable Scaffold in Antifungal Peptide Design

Cited by 3 publications

References 30 publications

The structural and functional reliability of Circulins of Chassalia parvifolia for peptide therapeutic scaffolding

The structural and functional reliability of Circulins of Chassalia parvifolia for peptide therapeutic scaffolding

Structural Stability Among Hybrid Antimicrobial Peptide Cecropin A(1–8)–Magainin 2(1–12) and Its Analogues: A Computational Approach

Biomolecules of the Horseshoe Crab’s Hemolymph: Components of an Ancient Defensive Mechanism and Its Impact on the Pharmaceutical and Biomedical Industry

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