Assortment research of analgesic drugs for chronic pain treatment on pharmaceutical market of Ukraine

Zupanets, Ihor; Рубан, О. А.; Євтушенко, О. М.; Kolisnyk, Tetiana

doi:10.32352/0367-3057.3.20.02

Cited by 2 publications

(2 citation statements)

References 2 publications

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“…Paracetamol (PAR), ibuprofen, naproxen, naproxen, diclofenac, indomethacin, ketoprofen, etc. are recommended for the treatment of CP according to national and international protocols and recommendations [8]. The use of PAR in the treatment of CP is due to the safety of the drug and fewer side effects compared to other NSAIDs (primarily, the lack of gastro-and cardiotoxicity) [9,10].…”

Section: Introductionmentioning

confidence: 99%

Pharmacological and biopharmaceutical studies of paracetamol and N-acetyl-D-glucosamine combination as an analgetic drug

Рубан

Zupanets

Kolisnyk

et al. 2022

SR: PS

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The aim. Experimental selection of paracetamol and N-acetyl-D-glucosamine (NAG) ratio and combined dose and bioavailability study of the pharmaceutical composition and active pharmaceutical ingredient (API) in the model of cell biomembranes. Materials and methods. The following substances were used: paracetamol, Actimask Acetaminophen (gelatin-coated paracetamol), and NAG. For pharmacological studies were used laboratory rats, which received test objects intragastrically. The study was performed on the model of inflammatory hyperalgesia according to the Randall-Selitto method. The values of pain threshold before and after pathology induction were established. For biopharmaceutical studies, dry L-α-dimyristoylphosphatidylcholine purchased from Avanti Polar Lipids (purity 99.9 %) was used, hydrated with an appropriate amount of double-distilled water to obtain 70 % wt./wt. water dispersion. Differential scanning calorimetry (DSC) studies were performed employing DSC 1 microcalorimeter (Mettler Toledo). Pharmaceuticals investigated were placed on the bottom of a crucible, then a proper amount of the lipid membrane was added and this moment was taken as the time reference point (t=0). Then a crucible was sealed with a lid and a sample was undergone consecutive temperature scans, heating from 0 to 35 ºC at a scanning rate of 2 ºC/min. The procedure was repeated until no more changes in DSC profiles were observed, i.e. system equilibrium was reached. Results. It has been experimentally proven that the combination of paracetamol and NAG in the ratio of 4:1 showed better analgesic efficacy. The dose of active ingredients was determined to be 50 mg/kg by the sum of API. The active interaction of paracetamol with the bilayer of biomembranes was established and it was determined that Actimask has a worse rate of penetration into the membrane due to the coating of paracetamol with a gelatin shell. NAG didn't significantly affect the rate of penetration of Actimask through the bilayer of membranes, but the auxiliary components of the tablet mixture significantly improved the rate and completeness of penetration of paracetamol through the bilayer of biomembranes. Conclusions. The study found the most effective ratio between paracetamol and NAG in the composition, which is 4:1. The next step was to determine the dose of API, which is 50 mg/kg of the sum of active substances. It has been determined that paracetamol has good permeability through the bilayer of biomembranes, and the tablet mass significantly improves the permeability of paracetamol

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Section: Introductionmentioning

confidence: 99%

Pharmacological and biopharmaceutical studies of paracetamol and N-acetyl-D-glucosamine combination as an analgetic drug

Рубан

Zupanets

Kolisnyk

et al. 2022

SR: PS

Self Cite

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“…If 1-2 tablets are prescribed for therapeutic purposes depending on the severity of pain, 1-4 times a day, then drug addicts take this drug in an amount of more than 5 tablets at a time. In this case, there may be a pronounced psychomotor agitation, delusional disorders and euphoria accompanied by visual hallucinations [5].…”

Section: Introductionmentioning

confidence: 95%

Development of methods for the study of dicyclomine hydrochloride in combination with paracetamol as an object of forensic-pharmaceutical examination

Бевз

Sych²,

Fedosov

et al. 2022

SR: PS

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The aim. Selection and development of methods for the tasks of forensic pharmaceutical examination as case materials suspected of falsification or non-medical use of dicyclomine hydrochloride in combination with paracetamol in the form of tablets. Materials and methods. The study presents the developed methods of detection and identification of dicyclomine by TLC, IR spectroscopy and GC-MS, which were performed using reagents that meet the EP, USP and USPU requirements, Class A glassware and qualified devices. Identification by IR spectroscopy was performed in the range from 500 to 4000 cm-1 on the device “Nicolet 380 FT-IR Spectrometer by Thermo Fisher Scientific”. TLC was performed on Sorbfil plates for TLC-PET-H-UV and Sorbfil plates for TLC-AF-UV (CJSC “Sorbpolymer”, Russia). The following systems were used as mobile phases: dioxane-chloroform-acetone-25 % ammonia solution (47.5:45:5:2.5); toluene-acetone-ethanol-25 % ammonia solution (45:45:7.5:2.5); ethyl acetate-methanol-25 % ammonia solution (17:2:1)). The resulting chromatographic zones were detected by irradiation with UV light and further treatment with color reagents (30 % iron (III) chloride solution; Dragendorff's reagent modified by Munier; Marquis reagent; Froehde reagent; Mandelin reagent; FPN reagent). Analysis by gas chromatography with mass detection was performed using a gas chromatograph with a mass spectrometric detector GCMS-QP2020. Data were analyzed using the program: GCMSsolution, LabSolutions Insight (Shimadzu Corporation, Tokyo, Japan). Results. For the first time, the conditions for the extraction of dicyclomine hydrochloride from aqueous solutions were studied and the optimal conditions for their isolation as an object of forensic pharmaceutical examination is defined. The method of detection of dicyclomine hydrochloride and paracetamol in the drug “Trigan-D” by the methods of thin-layer chromatography, gas-liquid chromatography and chromato-mass spectrometry was developed, and the detection limits of the substances under study were determined. Conclusion. The developed methods for dicyclomine hydrochloride in the form of tablets with paracetamol meet the requirements of the current legislation of Ukraine and the Ministry of Justice of Ukraine. The data obtained prove the high sensitivity and reproducibility of the methods and prove the possibility of their introduction into the practice of forensic pharmaceutical examination

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Assortment research of analgesic drugs for chronic pain treatment on pharmaceutical market of Ukraine

Cited by 2 publications

References 2 publications

Pharmacological and biopharmaceutical studies of paracetamol and N-acetyl-D-glucosamine combination as an analgetic drug

Pharmacological and biopharmaceutical studies of paracetamol and N-acetyl-D-glucosamine combination as an analgetic drug

Development of methods for the study of dicyclomine hydrochloride in combination with paracetamol as an object of forensic-pharmaceutical examination

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