Astaxanthin and DHA supplementation ameliorates the proteomic profile of perinatal undernutrition-induced adipose tissue dysfunction in adult life

Abstract

Maternal diet is an essential factor that directly and indirectly regulates fetal growth. Exposure to certain environmental conditions substantially impacts an individual's short- and long-term health. Adipose tissue dysfunction is a worldwide chronic disease caused by improper lipid build-up in adipose tissue leading to obesity. Therefore, it is the need of the hour to invent anti-obesity agents. As a keto–carotenoid, Astaxanthin (AsX) has been shown to have preventive effects against problems associated with obesity. A crucial role in the pathogenesis of obesity has been attributed to dietary polyunsaturated fatty acids. Adipose tissue plays a vital role in maintaining overall body homeostasis. Metabolic dysfunction of white adipocytes forms a critical step in the emergence of insulin resistance and related diseases. Here we aim to investigate the effect of AsX and Docosahexaenoic acid (DHA) supplementation on the proteomic profile of perinatal undernutrition-induced adipose tissue dysfunction in adult life using a rat model. The LC–MS/MS quantitative proteomics enabled us to identify differentially expressed proteins in perinatal undernourished but AsX and DHA-supplemented animal models. Data are available via ProteomeXchange with identifier PXD041772.This study explored biological roles, molecular functions of differentially expressed proteins, and pathways related to adipose tissue dysfunction induced by undernutrition and its effective modulation by AsX and DHA.

Astaxanthin and DHA supplementation modulates the perinatal undernutrition induced impairment of cognitive behaviour and synaptic plasticity in the adult life -Exploring the molecular mechanism

“…Our previous study revealed that a 30% reduction in maternal diet during pregnancy induces stress, which leads to adipose tissue dysfunction in adult life. Treatment with AsX and DHA signi cantly improved the perinatal undernutrition-induced differential protein expression in adipose tissue [42].…”

Captivating Colors, Crucial Roles: Astaxanthin’s Antioxidant Impact on Fish Oxidative Stress and Reproductive Performance

“…For instance, transcriptomic investigations can uncover the gene networks linked with growth promotion, immune modulation, and antioxidant defense in response to astaxanthin supplementation [179,180]. Proteomic assessments can pinpoint specific proteins subject to upregulation or downregulation upon astaxanthin exposure, offering insight into the pivotal functional contributors involved in the observed effects [181]. Metabolomic profiling can divulge insights into the metabolic shifts prompted by astaxanthin and unearth potential indicators of its advantageous outcomes [182].…”