Astaxanthin attenuates hepatic steatosis in high-fat diet-fed rats by suppressing microRNA-21 via transactivation of nuclear factor erythroid 2-related factor 2

Shatoor, Abdullah S.; Almohiy, Hussain

doi:10.1007/s13105-021-00850-9

Cited by 23 publications

(10 citation statements)

References 111 publications

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“…On the other hand, these metabolic results indirectly suggested that the improvements in muscle function with AX supplementation were not solely dependent on changes in body fat. Food intake did not significantly differ between the HFD and AX groups in this study, consistent with previous studies that displayed anti-obesity effects of AX in animal models fed a HFD without effecting food and calorie intake [ 68 , 69 , 70 ]. Mechanisms included inhibiting lipogenesis, promoting lipolysis and enhancing the antioxidant system [ 69 , 70 ].…”

Section: Discussionsupporting

confidence: 92%

“…Food intake did not significantly differ between the HFD and AX groups in this study, consistent with previous studies that displayed anti-obesity effects of AX in animal models fed a HFD without effecting food and calorie intake [ 68 , 69 , 70 ]. Mechanisms included inhibiting lipogenesis, promoting lipolysis and enhancing the antioxidant system [ 69 , 70 ]. Ren et al found that AX assisted in slowing skeletal muscle atrophy in H22 tumor-bearing mice, without effecting food intake [ 51 ].…”

Section: Discussionsupporting

confidence: 92%

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Astaxanthin Ameliorates Worsened Muscle Dysfunction of MDX Mice Fed with a High-Fat Diet through Reducing Lipotoxicity and Regulating Gut Microbiota

Chen,

Ling,

Chen

et al. 2023

Nutrients

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Duchenne muscular dystrophy (DMD), a severe X-linked inherited neuromuscular disease, has a high prevalence of obesity. Obesity exacerbates muscle damage and results in adverse clinical outcomes. Preventing obesity helps DMD patients delay disease progression and improve quality of life. Astaxanthin (AX) is a kind of carotenoid which has antioxidant and anti-adipogenesis effects. In this study, male C57BL/10ScSnDmdmdx/J mice were fed with a normal diet, a high-fat diet (HFD), and an HFD containing AX for 16 weeks, respectively. The results showed that AX significantly increased gastrocnemius fiber cross-section area and grip strength, improved treadmill endurance test and mitochondrial morphology, and reduced muscle triglyceride and malonaldehyde levels compared to the HFD. Lipidomic analysis revealed that AX decreased high levels of triglyceride, diglyceride, ceramides, and wax ester induced by HFD. Gut microbiota analysis indicated that AX supplementation failed to alleviate abnormal microbiota diversity, but increased the relative abundances of Akkermansia, Bifidobacterium, Butyricicoccus, and Staphylococcus. In conclusion, AX was expected to alleviate disease progression associated with obesity in DMD patients by reducing lipotoxicity and increasing the abundance of beneficial bacteria.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 92%

Astaxanthin Ameliorates Worsened Muscle Dysfunction of MDX Mice Fed with a High-Fat Diet through Reducing Lipotoxicity and Regulating Gut Microbiota

Chen,

Ling,

Chen

et al. 2023

Nutrients

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“…The selected doses of DOX and BBR, as well as the design of the experiment were selected in accordance with the study of Fouad et al, 44 which reported an antioxidant protection of BBR, at this dose, in DOX rat model. The in vivo administration of brusatol at this dose to block hepatic Nrf2 has been reported by Shatoor et al 46…”

Section: Selection Of Drug Dosesmentioning

confidence: 66%

The protection afforded by Berberine against chemotherapy‐mediated nephropathy in rats involves regulation of the antioxidant axis

Alagal

AlFaris

Alshammari

et al. 2022

Basic Clin Pharma Tox

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Doxorubicin (DOX) treatment in cancer patients leads to nephrotoxicity. The nephroprotective effect of Berberine (BBR), a herbal ingredient, is well documented as antioxidant and activation of the Nrf2 signalling. This study aimed to investigate if Nrf2 is a major protective mechanism of BBR in DOX animal models. Rats were divided as (n = 6 each): Control, BBR (100 mg/kg, orally), DOX (15 mg/kg, orally), BBR + DOX, and BBR + DOX + brusatol (0.2 mg/kg, i.p./twice per week) (an Nrf2 inhibitor). DOX was given as a single dose (day 10), whereas BBR was administered for 3 weeks on a daily basis. BBR reduced tubular degeneration and improved renal markers in DOX‐treated rats. It also reduced renal nuclear levels of NF‐κB p65, total reactive oxygen species (ROS), lipid peroxides, interleukin‐6 (IL‐6), and tumour necrosis factor‐α (TNF‐α), as well as mRNA levels of Bax and cleaved caspase‐3. However, BBR stimulated glutathione (GSH) and superoxide dismutase (SOD) levels, the transcription of Bcl2, and the mRNA, total cytoplasmic, and nuclear levels of Nrf2 with no effect on the cytoplasmic keap1 levels. All these effects disappeared by brusatol. In conclusion, BBR prevents DOX‐induced renal damage by activating Nrf2.

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“…Zingerone at the selected dose (1/10 or the LD50) was shown to be a therapeutic dose in rats that protected against HFD-induced NAFLD and hepatic oxidative damage, alloxan-induced diabetic complications, inflammation, oxidative stress, ethanol-induced gastric ulcer, carbon tetrachloride (CCl4)-induced nephropathy ( Ahmad et al, 2018 , Safhi, 2018 ). The regimen of brusatol was used by many authors to suppress tissue activation of Nrf2 in vivo ( Bovilla et al, 2021 , Shatoor et al, 2021 ).…”

Section: Methodsmentioning

confidence: 99%

Zingerone attenuates intestinal injury and colitis caused by a high-fat diet through Nrf2 signaling regulation

BinMowyna

2023

Saudi Journal of Biological Sciences

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Astaxanthin attenuates hepatic steatosis in high-fat diet-fed rats by suppressing microRNA-21 via transactivation of nuclear factor erythroid 2-related factor 2

Cited by 23 publications

References 111 publications

Astaxanthin Ameliorates Worsened Muscle Dysfunction of MDX Mice Fed with a High-Fat Diet through Reducing Lipotoxicity and Regulating Gut Microbiota

Astaxanthin Ameliorates Worsened Muscle Dysfunction of MDX Mice Fed with a High-Fat Diet through Reducing Lipotoxicity and Regulating Gut Microbiota

The protection afforded by Berberine against chemotherapy‐mediated nephropathy in rats involves regulation of the antioxidant axis

Zingerone attenuates intestinal injury and colitis caused by a high-fat diet through Nrf2 signaling regulation

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