Astaxanthin enhances pemetrexed-induced cytotoxicity by downregulation of thymidylate synthase expression in human lung cancer cells

Liao, Kai‐Sheng; Wei, Chia-Li; Chen, Jyh-Cheng; Zheng, Hongchao; Chen, Wen-Ching; Wu, Chia-Hung; Wang, Tai-Jing; Peng, Yi-Shuan; Chang, Po‐Yuan; Lin, Yun‐Wei

doi:10.1016/j.yrtph.2016.09.031

Cited by 23 publications

(11 citation statements)

References 38 publications

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“…In addition, astaxanthin has beneficial health effects against the formation of prostate carcinogenesis and tumor progression by reactivating the expression of Nrf2 and Nrf2-target genes through epigenetic modification and chromatin remodeling [80]. Astaxanthin has been shown to have antitumorigenic and anti-inflammatory effects on human lung cancer cell lines by inhibiting ERK1/2 activity [81].…”

Section: Antioxidant Functions Of Carotenoids At Molecular Level For mentioning

confidence: 99%

The Biochemistry and Antioxidant Properties of Carotenoids

Merhan¹

2017

Carotenoids

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Carotenoids are one of the most widespread pigment groups distributed in nature, and more than 700 natural carotenoids have been described so far, and new carotenoids are introduced each year. Carotenoids are derived from 4 terpenes, including totally 40 carbon atoms. Carotenoids are naturally synthesized by cyanobacteria, algae, plants, some fungi, and some bacteria, but not made by mammals. Lately, the beneficial properties of α-carotene, β-carotene, γ-carotene, lycopene, phytoene, phytofluene, lutein, zeaxanthin, β-cryptoxanthin, astaxanthin, and fucoxanthin carotenoids in prevention of various diseases, such as tumor formation, cardiovascular, and vision, have been documented due to their roles as antioxidants, activation in certain gene expression associated with cell-to-cell communication, provitamin A activity, modulation of lipoxygenase activity, and immune response. In this chapter, in addition to biochemical properties of carotenoids, how the structure of these molecules influences the oxidative stress in health and reducing the risk of formation of various diseases will be described.

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Section: Antioxidant Functions Of Carotenoids At Molecular Level For mentioning

confidence: 99%

The Biochemistry and Antioxidant Properties of Carotenoids

Merhan¹

2017

Carotenoids

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“…Scientists have therefore, turned to alternative or complementary strategies. In this sense, natural product-based compounds that have been used in traditional therapy for centuries are frequently researched for their anticancer activities (Nagendraprabhu and Sudhandiran, 2011;Liao et al, 2016). From this point of view, we think that the results of this study, which examined the selective cytotoxic effect of ASX on A549 and WiDr cells for the first time, are important.…”

Section: Resultsmentioning

confidence: 92%

“…Lung cancer is one of the deadliest malignancies in the world, and non-small cell lung cancer (NSCLC) accounts for more than 85% of all lung cancer cases (Liao et al, 2016). Colon cancer is the third most malignant neoplasm in the world and remains an important cause of mortality in Asian and Western countries (Nagendraprabhu and Sudhandiran, 2011).…”

Section: Resultsmentioning

confidence: 99%

Selective Cytotoxic Effect of Astaxanthin on Human Lung and Colon Cancer Cells

Demir

Aliyazıcıoğlu

2020

Kahramanmaraş Sütçü İmam Üniversitesi Tarım Ve Doğa Dergisi

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Astaxanthin (ASX) is a red xanthophyll carotenoid found in various microorganisms and marine animals. ASX is also called the "super antioxidant" because it has the highest antioxidant activity among existing carotenoids. Studies have shown not only antioxidant properties but also antimicrobial, immunomodulatory, hepatoprotective, anticancer and antidiabetic properties of ASX. However, there is a limited number of studies examining the selective cytotoxic effects of ASX on cancer cells. The aim of this study was to determine the cytotoxic effects of ASX on cells representing common cancer types. For this, human breast (MCF-7), lung (A549), liver (HepG2), melanoma (VMM917), colon (WiDr) cancer and normal fibroblast cells were treated with different concentrations of ASX for 72 h and then the MTT assay protocol was applied. Cisplatin was used as a positive control in cytotoxicity experiments. The results showed that ASX had a dose-dependent cytotoxic effect on all studied cancer cell lines. However, the strongest selective cytotoxic effect of ASX was determined in A549 and WiDr cells compared to fibroblast cells. This study shows that selective cytotoxic effect of ASX should be investigated more extensively, especially in terms of lung and colon cancer.

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“…Astaxanthin (ATX) is a ketone carotene widely found in shrimp, salmon, crab, red yeast, and other marine animals 73 . It exerts strong antioxidant activity, anti‐tumor effects, anti‐inflammatory effects, and hepatoprotective effects 74 .…”

Section: Antineoplastic Drugs Classified By Sourcementioning

confidence: 99%

“…In 1987, ATX was approved by the USFDA as a feed additive for aquaculture and was subsequently approved as a dietary supplement in 1999 75 . In addition, numerous evidence has shown that ATX exerts anticancer effects on many types of cancers, including lung cancer, colon cancer, lung cancer, and breast cancer 73,76 …”

Section: Antineoplastic Drugs Classified By Sourcementioning

confidence: 99%