Astaxanthin-enriched-diet reduces blood pressure and improves cardiovascular parameters in spontaneously hypertensive rats

Monroy-Ruiz, José; Sevilla, María A.; Carrón, Rosalı́a; Montero, María J.

doi:10.1016/j.phrs.2010.09.003

Cited by 92 publications

(58 citation statements)

References 45 publications

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“…Astaxanthin (135) decreased NADPH enhanced O 2·-production by direct ROS scavenging and improved NO bioavailability. Both activities were accompanied by an antihypertensive effect [81].…”

Section: Cardioprotectionmentioning

confidence: 96%

Terpene Compounds in Nature: A Review of Their Potential Antioxidant Activity

González-Burgos

Gómez-Serranillos

2012

CMC

297

157

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Reactive Oxygen Species are involved in the pathological development of many important human diseases such as neurodegenerative diseases, cardiovascular processes, diabetes and many others. The most promising strategy to prevent from the oxidative damage caused by these reactive species is the use of antioxidant molecules. These compounds can act as direct antioxidants through free radical scavenging mechanisms and/or as indirect antioxidants by enhancing the antioxidant status (enzymatic and non-enzymatic). Terpenes, one of the most extensive and varied structural compounds occurring in nature, display a wide range of biological and pharmacological activities. Here we highlight their antioxidant properties. Due to their antioxidant behaviour terpenes have been shown to provide relevant protection under oxidative stress conditions in different diseases including liver, renal, neurodegenerative and cardiovascular diseases, cancer, diabetes as well as in ageing processes. Evidence for this comes from the increasing number of publications on this issue in recent years. This review provides a complete overview of the natural terpenes with potential antioxidant properties, focusing on their source, structures, antioxidant mechanisms through which they exert their pharmacological and possible therapeutic activities.

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“…Astaxanthin (135) decreased NADPH enhanced O 2·-production by direct ROS scavenging and improved NO bioavailability. Both activities were accompanied by an antihypertensive effect [81].…”

Section: Cardioprotectionmentioning

confidence: 96%

Terpene Compounds in Nature: A Review of Their Potential Antioxidant Activity

González-Burgos

Gómez-Serranillos

2012

CMC

297

157

View full text Add to dashboard Cite

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“…␤-carotene was reported to protect renal tissues against I/R-induced oxidative damage (50,51). In spontaneously hypertensive rats, astaxanthin (a water-dispersible synthetic carotenoid)-enriched diet for 8 wk decreased oxidative stress, lowered systolic blood pressure, attenuated left ventricular hypertrophy, and improved endothelial function (86). In renal and hepatic I/R models, astaxanthin treatment reduced I/R injury (25).…”

Section: Dietary Sources Of Antioxidantsmentioning

confidence: 99%

Antioxidant-based therapies for angiotensin II-associated cardiovascular diseases

Rosenbaugh

Savalia

Manickam

et al. 2013

American Journal of Physiology-Regulatory, Integrative and Comp

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Cardiovascular diseases, including hypertension and heart failure, are associated with activation of the renin-angiotensin system (RAS) and increased circulating and tissue levels of ANG II, a primary effector peptide of the RAS. Through its actions on various cell types and organ systems, ANG II contributes to the pathogenesis of cardiovascular diseases by inducing cardiac and vascular hypertrophy, vasoconstriction, sodium and water reabsorption in kidneys, sympathoexcitation, and activation of the immune system. Cardiovascular research over the past 15-20 years has clearly implicated an important role for elevated levels of reactive oxygen species (ROS) in mediating these pathophysiological actions of ANG II. As such, the use of antioxidants, to reduce the elevated levels of ROS, as potential therapies for various ANG II-associated cardiovascular diseases has been intensely investigated. Although some antioxidant-based therapies have shown therapeutic impact in animal models of cardiovascular disease and in human patients, others have failed. In this review, we discuss the benefits and limitations of recent strategies, including gene therapy, dietary sources, low-molecular-weight free radical scavengers, polyethylene glycol conjugation, and nanomedicine-based technologies, which are designed to deliver antioxidants for the improved treatment of cardiovascular diseases. Although much work has been completed, additional research focusing on developing specific antioxidant molecules or proteins and identifying the ideal in vivo delivery system for such antioxidants is necessary before the use of antioxidant-based therapies for cardiovascular diseases become a clinical reality.

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“…Its promising healthy benefits include antioxidant activities [208][209][210], including enhancement of the immune system [211,212] and protection of the cardiovascular system [213]. Astaxanthin has important food applications as it can be used as a colorant additive in foods because of its colour and antioxidant capacity.…”

Section: Bioactivitiesmentioning

confidence: 99%

“…Monroy et al [213] reported that supplementing the diet with astaxanthin had beneficial effects on hypertension, by decreasing blood pressure, improving cardiovascular remodeling and oxidative stress. The results suggested that systolic blood pressure was lower in astaxanthin-treated groups than the control group from the first week of treatment, and the left ventricular hypertrophy index (LVH) was significantly reduced.…”

Section: Cardiovascular Disease Preventionmentioning

confidence: 99%

Marine shells: Potential opportunities for extraction of functional and health-promoting materials

Hou

Shavandi

Carne

et al. 2016

Critical Reviews in Environmental Science and Technology

110

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Marine shell waste is a very rich source of several bioactive compounds and materials, such as calcium, chitin, pigments and proteins. Currently, this waste material is greatly underutilized and contributes to significant environmental problems due to off odour and concentration of minerals in landfill. The main objective of this review is to highlight the potential to value-add to and maximize the utilization of this waste stream. Therefore, this review provides up to date Downloaded by [University of California Santa Barbara] at 06:53 25 June 2016 ACCEPTED MANUSCRIPT ACCEPTED MANUSCRIPT 2information on various compounds available in marine shells that are generated as waste co-product from commercial processing operations and their potential uses. Methods are described for extraction of these compounds for use in food and pharmaceutical applications.

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Astaxanthin-enriched-diet reduces blood pressure and improves cardiovascular parameters in spontaneously hypertensive rats

Cited by 92 publications

References 45 publications

Terpene Compounds in Nature: A Review of Their Potential Antioxidant Activity

Terpene Compounds in Nature: A Review of Their Potential Antioxidant Activity

Antioxidant-based therapies for angiotensin II-associated cardiovascular diseases

Marine shells: Potential opportunities for extraction of functional and health-promoting materials

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