2021
DOI: 10.1016/j.ejphar.2021.174336
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Astaxanthin prevents mitochondrial impairment in the dopaminergic SH-SY5Y cell line exposed to glutamate-mediated excitotoxicity: Role for the Nrf2/HO-1/CO-BR axis

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Cited by 12 publications
(8 citation statements)
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“…However, MRS2500, the selective antagonist of P2Y1 receptors, completely abolished the neuroprotection of extracellular ATP ( Figure 1F ). Finally, we tested whether glutamate triggered apoptosis in SH-SY5Y cells and no apoptotic cells were observed ( Supplementary Figure 2 ), in accordance with the previous study ( Brasil et al, 2021 ). Taken together, these results demonstrated that extracellular ATP protects SH-SY5Y cells from glutamate-mediated excitotoxicity via the P2Y1 receptors.…”
Section: Resultssupporting
confidence: 53%
“…However, MRS2500, the selective antagonist of P2Y1 receptors, completely abolished the neuroprotection of extracellular ATP ( Figure 1F ). Finally, we tested whether glutamate triggered apoptosis in SH-SY5Y cells and no apoptotic cells were observed ( Supplementary Figure 2 ), in accordance with the previous study ( Brasil et al, 2021 ). Taken together, these results demonstrated that extracellular ATP protects SH-SY5Y cells from glutamate-mediated excitotoxicity via the P2Y1 receptors.…”
Section: Resultssupporting
confidence: 53%
“…To the best of our knowledge, only a recent study has evaluated the effect of astaxanthin, a potent antioxidant carotenoid, in glutamate-induced SH-SY5Y. The results suggested that this carotenoid could prevent mitochondrial impairment, and thus exert a neuroprotective effect [ 31 ].…”
Section: Discussionmentioning
confidence: 99%
“…Given this crucial cytoprotective regulatory role for genes and proteins, the Nrf2/HO-1 axis in neuroprotection is considered as the focus research in recent years under normal and pathological conditions ( Espada et al, 2010 ). It is also involved in neural resistance to oxidative stress and glutamate-induced excitotoxicity ( Brasil et al, 2021 ). It is known that astrocytes protect neurons from damage by regulating Nrf2 signaling, but little is known about how astrocytes regulate neuronal Nrf2 signaling ( Habas et al, 2013 ).…”
Section: Discussionmentioning
confidence: 99%