Astaxanthin production by Xanthophyllomyces dendrorhous growing on a low cost substrate

Gervasi, Teresa; Santini, Antonello; Daliu, Patricia; Salem, Abdelfattah Z.M.; Gervasi, C.A.; Pellizzeri, Vito; Barrega, Luna; Pasquale, Paolo De; Dugo, Giacomo; Cicero, Nicola

doi:10.1007/s10457-018-00344-6

Cited by 49 publications

(22 citation statements)

References 29 publications

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“…Astaxanthin is an important ketocarotenoid that is widely used in the food, aquaculture, nutraceutical and pharmaceutical industries because of its strong antioxidant activity (Rodríguez‐Sáiz et al , 2010; Schmidt et al , 2011) and numerous biological functions (Gong and Bassi, 2016). The global astaxanthin market has grown significantly in recent years (Gervasi et al , 2019). The basidiomycetous red yeast Xanthophyllomyces dendrorhous (asexual state Phaffia rhodozyma ) belongs to a basal lineage of the Agaricomycotina within the Tremellomycetes and possesses a set of unique characteristics of outstanding economic and ecological value (Golubev, 1995; Fell and Blatt, 1999; Bellora et al , 2016; Gervasi et al , 2018).…”

Section: Introductionmentioning

confidence: 99%

Enhancing astaxanthin accumulation in Xanthophyllomyces dendrorhous by a phytohormone: metabolomic and gene expression profiles

Pan

Wang

Duan

et al. 2020

Microbial Biotechnology

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Xanthophyllomyces dendrorhous is a promising source of natural astaxanthin due to its ability to accumulate high amounts of astaxanthin. This study showed that 6-benzylaminopurine (6-BAP) is an effective substrate that enhances cell biomass and astaxanthin accumulation in X. dendrorhous. In the current study, the biomass and astaxanthin content in X. dendrorhous were determined to be improved by 21.98% and 24.20%, respectively, induced by 6-BAP treatments. To further understand the metabolic responses of X. dendrorhous to 6-BAP, time-course metabolomics and gene expression levels of X. dendrorhous cultures with and without 6-BAP feeding were investigated. Metabolome analysis revealed that 6-BAP facilitated glucose consumption, promoted the glycolysis, suppressed the TCA cycle, drove carbon flux of acetyl-CoA into fatty acid and mevalonate biosynthesis, and finally facilitated the formation of astaxanthin. ROS analysis suggested that the antioxidant mechanism in X. dendrorhous can be induced by 6-BAP. Additionally, the process of 6-BAP significantly upregulated the expression of six key genes involved in pathways related to astaxanthin biosynthesis. This research demonstrates the metabolomic mechanism of phytohormone stimulation of astaxanthin production iNn X. dendrorhous and presents a new strategy to improve astaxanthin production to prevent the dilemma of choosing between accumulation of astaxanthin and cell biomass.

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Section: Introductionmentioning

confidence: 99%

Enhancing astaxanthin accumulation in Xanthophyllomyces dendrorhous by a phytohormone: metabolomic and gene expression profiles

Pan

Wang

Duan

et al. 2020

Microbial Biotechnology

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“…The United States Food and Drug Administration has approved ASTA as an edible pigment in animal and fish feed, and the European Commission considers natural ASTA a food dye ( Singh et al., 2019 ). Recently, there has been a growing demand for ASTA from many industries, such as pharmaceutical, cosmetic, food, nutraceutical, and feed industries ( Gervasi et al., 2019 ). Therefore, ASTA is an ideal choice as a feed additive.…”

Section: Introductionmentioning

confidence: 99%

Effects of dietary supplementation of natural astaxanthin from Haematococcus pluvialis on antioxidant capacity, lipid metabolism, and accumulation in the egg yolk of laying hens

Gao

Heng

et al. 2020

Poultry Science

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The present study evaluated the effects of natural astaxanthin ( ASTA ) from Haematococcus pluvialis on the antioxidant capacity, lipid metabolism, and ASTA accumulation in the egg yolk of laying hens. Hy-Line Brown layers (n = 288, 50 wk old) were randomly assigned to 1 of 4 dietary treatment groups. Each group had 6 replicates of 12 hens each. All birds were given a corn-soybean meal–based diet containing 0, 25, 50, or 100 mg/kg ASTA for 6 wk. The results showed that the total antioxidant capacity, superoxide dismutase level, and glutathione peroxidase level in the plasma, livers, and egg yolks were significantly increased in the ASTA groups compared with those of the control group ( P < 0.05), whereas the content of malondialdehyde linearly decreased ( P < 0.05). The plasma levels of high-density and very-low-density lipoprotein cholesterol in the ASTA groups were significantly higher than those in the control group ( P < 0.05). In addition, ASTA supplementation decreased low-density lipoprotein cholesterol and triglyceride plasma levels ( P < 0.05). However, there were no significant differences in the other lipid metabolism parameters among the ASTA-supplemented groups relative to the control group except for an increase in high-density lipoprotein cholesterol in the liver. Compared with the control, dietary ASTA supplementation significantly increased the enrichment of ASTA in egg yolks at the end of week 2, 4, and 6 ( P < 0.05). The mRNA expression of scavenger receptor class B type 1 ( SCARB1 ) and very-low-density lipoprotein receptor ( VLDLR ) in the ASTA groups was markedly higher ( P < 0.05) than that in the control group in the liver and ovaries, respectively. In conclusion, these results suggest that dietary ASTA enhances the antioxidant capacity and regulates lipid metabolism in laying hens. ASTA enrichment in egg yolks may be closely related to the upregulation of SCARB1 and VLDLR gene expression.

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“…It is also poor in some metals, e.g., phosphorus, magnesium, and sodium, but it contains reasonable levels of manganese and zinc [22][23][24]. The ripening stage at harvest interferes with pectic polysaccharides, which are found in the OP cell walls due to the presence of calcium chelating dimers, thereby changing the nutritional value of this by-product [25].Whereas in the past, the use of crop residues and by-products as alternatives to cereals-soybean meal-based rations for broilers diet was not successful, mainly due to the high fiber content and poor digestibility, now it is increasing in interest [26][27][28]. Some exogenous enzymes may be added to broiler diets containing these by-products as an aid for fiber digestion (carbohydrases) or phytic phosphorus solubilization (phytase), thereby reducing their negative effects on broiler production [29].…”

Section: Introductionmentioning

confidence: 99%

Olive Pulp and Exogenous Enzymes Feed Supplementation Effect on the Carcass and Offal in Broilers: A Preliminary Study

et al. 2020

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Nowadays, there is an increasing interest in the exploitation and valorization of agricultural food waste and by-products. At the same time, the growing demand by markets worldwide, especially in Africa and Southeast Asia, can justify the growing interest in the use of by-products for the poultry industry. Olive pulp is one of the most interesting by-products of olive tree farming (typical of the Mediterranean area), being a good source of many biologically active compounds with antioxidant, antifungal, and antibacterial properties. The presence of processed olive pulp in the diet showed to be effective in increasing the weight of specific carcass and offal traits. This work aims at studying olive pulp as a feed supplement in poultry nutrition, by focusing on the effects on broiler carcass and offal. Olive pulp (OP) is one of the by-products of olive tree farming, being the residue of olive cake after it is dried. To evaluate the effects of OP in a diet supplemented with different levels of a commercial enzyme (ENZ) blend on broiler carcass and offal traits, three hundred male broiler chicks (Ross 308 lineage; one-day-old) were divided into ten treatment groups according to a completely randomized design. The treatments diets contained: unprocessed OP (50 g/kg, 100 g/kg, 50 g/kg with ENZ, 100 g/kg with ENZ), processed OP (50 g/kg, 100 g/kg, 50 g/kg with ENZ, 100 g/kg with ENZ), and control groups (without OP, and without OP with ENZ). The OP processing increased breast percentages in broilers. Supplementation with ENZ did not change any of the studied carcass or offal trait values. The presence of OP (50 g/kg) in broiler diets increased the eviscerated carcass, leg, and neck percentage values. The presence of processed OP (50 g/kg) in the diet showed to be effective in increasing the weight of specific carcass and offal traits.

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Astaxanthin production by Xanthophyllomyces dendrorhous growing on a low cost substrate

Cited by 49 publications

References 29 publications

Enhancing astaxanthin accumulation in Xanthophyllomyces dendrorhous by a phytohormone: metabolomic and gene expression profiles

Enhancing astaxanthin accumulation in Xanthophyllomyces dendrorhous by a phytohormone: metabolomic and gene expression profiles

Effects of dietary supplementation of natural astaxanthin from Haematococcus pluvialis on antioxidant capacity, lipid metabolism, and accumulation in the egg yolk of laying hens

Olive Pulp and Exogenous Enzymes Feed Supplementation Effect on the Carcass and Offal in Broilers: A Preliminary Study

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