Aster koraiensis extract lowers postprandial glucose in normoglycemic and high-fat-diet-induced obese mice

Kim, Jung-Hyun; Hyun, Soo‐Wang; Lee, Ik Soo; Jo, Kyuhyung; Kim, Young Sook; Kim, Jin Sook; Kim, Chan-Sik

doi:10.1007/s10068-018-0497-8

Cited by 4 publications

(3 citation statements)

References 22 publications

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“…A current study by He et al reported SPAG5 as “As emerging oncogene” for its overexpression in cancer types (He et al 2020). SPAG5 was also reported to be upregulated in most of the LUAD cell lines (Kim et al 2019), which further confirmed our analysis. Nevertheless, these predictions ought to be validated exhaustively through the clinical experiments and accomplished execution in LUAD therapy and treatment.…”

Section: Discussionsupporting

confidence: 90%

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Integrated Bioinformatics Analysis Deciphering the microRNA Regulation in Protein-Protein Interaction Network in Lung Adenocarcinoma

Sengupta¹,

Saha²,

Maji³

et al. 2020

Preprint

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Background: The architecture of the protein-protein interaction (PPI) network in any organism relies on their gene expression signature. microRNAs (miRNAs) have recently emerged as major post transcriptional regulators that control PPI by targeting mainly untranslated regions of the gene encoding proteins. Here, we aimed to unveil the role of miRNAs in the PPI network for identifying potential molecular targets for lung adenocarcinoma (LUAD). Materials and methods: The expression profiles of miRNAs and mRNAs were collected from the NCBI Gene Expression Omnibus (GEO) database (GSE74190 and GSE116959). Abnormally expressed mRNAs from the data were appointed to construct a PPI network and hence incorporated with the miRNA−mRNA regulatory network. The miRNAs and mRNAs in this network were subjected to functional enrichment. Through the network analysis, hubs were identified and their mutation rate and probability of cooccurrence were calculated. Results: We identified 17 miRNAs and 429 mRNAs signature for differentially altered transcriptome in LUAD. The combined miRNA−mRNA regulatory network exhibited scale−free characteristics. Network analysis showed 5 miRNA (including hsa−miR−486−5p, hsa−miR−200b−5p, and hsa−miR−130b−5p) and 10 mRNA (including ASPM, CCNB1, TTN, TPX2, and BIRC5) which expressively contribute in the LUAD. We further investigated the hub genes and noticed that ASPM and TTN had the maximum rate of mutation and possessed a high tendency of cooccurrence in LUAD. Conclusion: This study provides a unique network approach to the exploration of the underlying molecular mechanism in LUAD. Identified mRNAs and miRNAs may therefore, serve as significant prognostic predictors and therapeutic targets.

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Section: Discussionsupporting

confidence: 90%

“…A current study by He et al reported SPAG5 as "As emerging oncogene" for its overexpression in cancer types (He et al 2020). SPAG5 was also reported to be upregulated in most of the LUAD cell lines (Kim et al 2019), which further confirmed our analysis.…”

Section: Discussionsupporting

confidence: 88%

Integrated Bioinformatics Analysis Deciphering the microRNA Regulation in Protein-Protein Interaction Network in Lung Adenocarcinoma

Sengupta¹,

Saha²,

Maji³

et al. 2020

Preprint

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“…Certain components of AK, such as eudesmane-type sesquiterpene glucosides, caffeoylquinic acids (CQAs), astersaponin Ⅰ, and polyacetylenes, reportedly have physiological activities, including neuroprotective effects on Parkinson’s disease [ 25 , 26 , 27 , 28 , 29 ]. Additionally, AK has been determined to play a variety of other roles, including preventing diabetic nephropathy, improving anti-nociceptive diabetic retinopathy, inhibiting retinal angiogenesis, healing wounds, lowering postprandial glucose, and inhibiting inflammation [ 30 , 31 , 32 , 33 , 34 , 35 , 36 ]. However, the effects of AK leaf on cognitive dysfunction remain unclear.…”

Section: Introductionmentioning

confidence: 99%

Extract of Aster koraiensis Nakai Leaf Ameliorates Memory Dysfunction via Anti-inflammatory Action

Lee¹,

Park²,

Jang³

et al. 2023

IJMS

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Aster koraiensis Nakai (AK) leaf reportedly ameliorates health problems, such as diabetes. However, the effects of AK on cognitive dysfunction or memory impairment remain unclear. This study investigated whether AK leaf extract could attenuate cognitive impairment. We found that AK extract reduced the production of nitric oxide (NO), tumour necrosis factor (TNF)-α, phosphorylated-tau (p-tau), and the expression of inflammatory proteins in lipopolysaccharide- or amyloid-β-treated cells. AK extract exhibited inhibitory activity of control specific binding on N-methyl-D-aspartate (NMDA) receptors. Scopolamine-induced AD models were used chronically in rats and acutely in mice. Relative to negative controls (NC), hippocampal choline acetyltransferase (ChAT) and B-cell lymphoma 2 (Bcl2) activity was increased in rats chronically treated with scopolamine and fed an AK extract-containing diet. In the Y-maze test, spontaneous alterations were increased in the AK extract-fed groups compared to NC. Rats administered AK extract showed increased escape latency in the passive avoidance test. In the hippocampus of rats fed a high-AK extract diet (AKH), the expression of neuroactive ligand–receptor interaction-related genes, including Npy2r, Htr2c, and Rxfp1, was significantly altered. In the Morris water maze assay of mice acutely treated with scopolamine, the swimming times in the target quadrant of AK extract-treated groups increased significantly to the levels of the Donepezil and normal groups. We used Tg6799 Aβ-overexpressing 5XFAD transgenic mice to investigate Aβ accumulation in animals. In the AD model using 5XFAD, the administration of AK extract decreased amyloid-β (Aβ) accumulation and increased the number of NeuN antibody-reactive cells in the subiculum relative to the control group. In conclusion, AK extract ameliorated memory dysfunction by modulating ChAT activity and Bcl2-related anti-apoptotic pathways, affecting the expression of neuroactive ligand–receptor interaction-related genes and inhibiting Aβ accumulation. Therefore, AK extract could be a functional material improving cognition and memory.

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Isolation of polyacetylenes with proprotein convertase/kexin type 9 downregulating activity and two new sesquiterpenes from the aerial parts of Aster koraiensis

Nhoek

Ahn

Chae

et al. 2020

Tetrahedron Letters

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Aster koraiensis extract lowers postprandial glucose in normoglycemic and high-fat-diet-induced obese mice

Cited by 4 publications

References 22 publications

Integrated Bioinformatics Analysis Deciphering the microRNA Regulation in Protein-Protein Interaction Network in Lung Adenocarcinoma

Integrated Bioinformatics Analysis Deciphering the microRNA Regulation in Protein-Protein Interaction Network in Lung Adenocarcinoma

Extract of Aster koraiensis Nakai Leaf Ameliorates Memory Dysfunction via Anti-inflammatory Action

Isolation of polyacetylenes with proprotein convertase/kexin type 9 downregulating activity and two new sesquiterpenes from the aerial parts of Aster koraiensis

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