Asteroid hyalosis—a comprehensive review

Khoshnevis, Matin; Rosen, Sasha; Sebag, J.

doi:10.1016/j.survophthal.2019.01.008

Cited by 36 publications

(33 citation statements)

References 60 publications

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“…The literature does not provide any firm evidence for the existence of other risk factors. Diabetes has been considered, but no conclusive evidence has been found (Hatfield et al 1962;Bergren et al 1991;Moss et al 2001;Mitchell et al 2003;Fawzi et al 2005;Kim et al 2008) and the same goes for hypercholesterolaemia, arterial hypertension and hypercalcaemia (Khoshnevis et al 2019;Kim et al 2008). Spurious associations are likely to occur.…”

Section: Referencesmentioning

confidence: 99%

“…Asteroid hyalosis can significantly impair the clinical inspection of the fundus but, counterintuitively, has little or no impact on the patient's vision. When visual complaints are present, they have been associated with accumulation of asteroids in front of the fovea (Khoshnevis et al 2019). Asteroid hyalosis should not be confused with synchysis scintillans, which has a distinctly polychromatic angular appearance (Benson et al 1894).…”

Section: Introductionmentioning

confidence: 99%

“…opacities move with movements) and avoid gravitating downwards. The condition was initially called asteroid hyalitis (Benson et al 1894), which was later re-phrased in 1970s due to the absence of an inflammatory process (Khoshnevis et al 2019). Although the exact aetiology of asteroid hyalosis remains unknown, it has been consistently reported that the condition becomes increasingly prevalent with age (Moss et al 2001;Mitchell et al 2003;Fawzi et al 2005).…”

Section: Introductionmentioning

confidence: 99%

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Global prevalence of asteroid hyalosis and projection of its future burden: a systematic review and meta‐analysis

Møller-Lorentzen

Eckmann-Hansen

Faber

et al. 2020

Acta Ophthalmologica

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Asteroid hyalosis is defined by the presence of white, snowball‐like non‐crystalline vitreous opacities that move with the vitreous and appear to be anchored to its matrix. Asteroid hyalosis commonly occurs in the absence of other identifiable ocular abnormalities and is usually an incidental finding. The vitreous opacities are usually invisible to the patient and asymptomatic, but asteroid hyalosis can be a significant obstacle to the examination of the fundus. The prevalence increases dramatically with age. The aetiology is unknown. We systematically reviewed the literature for epidemiological data, qualitatively reviewed available studies, conducted meta‐analyses with demographical stratifications, evaluated temporal changes and estimated the future prevalence using forecasting analysis. Nine eligible studies were identified with data on 104 569 individuals. The overall population prevalence of asteroid hyalosis was 0.75% (95% confidence interval: 0.39–1.21%); however, the prevalence was highly age‐dependent, ranging from 0.27% (95% confidence interval 0.12–0.49%) in individuals aged 0–39 years and gradually increasing to 3.07% (95% confidence interval 1.90–4.50%) in individuals aged ≥80 years. Male gender was an additional risk factor (odds ratio 1.80, 95% confidence interval 1.32–2.45, p = 0.00017). The estimated global prevalence was 10.7 million subjects in year 1950, which is expected to increase to 41.5 million in year 2020 and 91.2 million in year 2100. The prevalence of asteroid hyalosis is relevant because it impacts the utility of diagnostic strategies, especially screening methods for conditions such as diabetic retinopathy.

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Section: Referencesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Global prevalence of asteroid hyalosis and projection of its future burden: a systematic review and meta‐analysis

Møller-Lorentzen

Eckmann-Hansen

Faber

et al. 2020

Acta Ophthalmologica

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“…This was not the case. In clinical practice, patients with a wide range of vitreous debris are seen, and often individuals with very substantial opacities can be essentially asymptomatic (as in asteroid hyalosis) 28 . Our result, as well as the wide variability in dysfunction among patients with similar vitreous opacities, suggests that the location and motion characteristics of the opacities may be more significant drivers than the level of opacity itself in the decision to seek symptomatic relief with surgery.…”

Section: Discussionmentioning

confidence: 99%

Reading Speed as an Objective Measure of Improvement Following Vitrectomy for Symptomatic Vitreous Opacities

Ryan¹,

Lam²,

Pulido³

et al. 2020

Ophthalmic Surg Lasers Imaging Retina

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Background and Objective: There is currently no objective measure of the visual deficits experienced by patients with symptomatic vitreous opacities (SVO) that would also correlate with the functional improvement they report following vitrectomy. This study aims to determine whether reading speed can be used as a reliable outcome measure to assess objectively the impact of both SVO and vitrectomy on patients' visual performance. Study Design/Materials and Methods: 20 adult patients seeking surgery for SVO were included. Measures of visual function were obtained before and after vitrectomy using the ETDRS acuity chart, the NEI-VFQ and the MNREAD. Results: In patients with non-opacified lenses (N=10), maximum reading speed increased significantly from 138 to 159 words per minute after complete removal of SVO by vitrectomy (95%CI = [14, 29], p < 0.001). Conclusion: Reading speed is impaired with SVO, and improves following vitrectomy in phakic and pseudophakic eyes with clear lenses. Reading speed is a valid objective measure to assess the positive effect of vitrectomy for SVO on near-distance daily life activities.

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“…Asteroid hyalosis (AH) is a benign, degenerative condition of fatty calcium soap deposits in the vitreous that usually occurs unilaterally and typically occurs in men ages 75–86 1–4. Previous research has shown that these spherical asteroid bodies are composed of calcium and phosphate complexed with lipids and are usually asymptomatic 1,5. Asteroid bodies can be visualized by ophthalmoscope examination as well as B-mode ultrasonography, as this case demonstrates, with a shimmering, starry-night appearance to the vitreous.…”

Section: Diagnosismentioning

confidence: 99%