Asterosaponins Isolated from the Starfish Asterias amurensis

Hwang, In Hyun; Kim, Dong Woo; Kim, Su Jeong; Min, Byung Sun; Lee, Seung Ho; Son, Jong Keun; Kim, Cheorl-Ho; Chang, Hyeun Wook; Na, MinKyun

doi:10.1248/cpb.59.78

Cited by 13 publications

(3 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Compound 61 contains a 22,23‐epoxy‐20‐hydroxy‐stigmastane side chain never found in other asterosaponins earlier . Compounds 64 and 65 were obtained as a mixture (1:1) …”

Section: Chemical Constituentsmentioning

confidence: 99%

Chemical Constituents and Bioactivities of Starfishes: An Update

Xia

Miao

Xie

et al. 2020

Chemistry & Biodiversity

View full text Add to dashboard Cite

Starfishes produce various structurally unique secondary metabolites with diverse biological activities. This review is an update summary of the new compounds and their bioactivities from starfish (the Asteroidea Class) with 71 references covering from January 2007 to December 2018. During this period, 216 new compounds were obtained from 36 species. The chemical constituents are mostly steroids, steroidal glycosides, and gangliosides. These components have been found to possess various bioactivities, including anticancer, anti-inflammation, etc.

show abstract

“…Compound 61 contains a 22,23‐epoxy‐20‐hydroxy‐stigmastane side chain never found in other asterosaponins earlier . Compounds 64 and 65 were obtained as a mixture (1:1) …”

Section: Chemical Constituentsmentioning

confidence: 99%

Chemical Constituents and Bioactivities of Starfishes: An Update

Xia

Miao

Xie

et al. 2020

Chemistry & Biodiversity

View full text Add to dashboard Cite

show abstract

“…Autotomy (i.e., found in Evasterias troschelii and Pycnopodia helianthoides), spines, modified tube feet called "pedicellaria," camouflage, quick locomotion, and shedding have been reported as physical defenses (Bryan et al 1997;Candia Carnevali and Bonasoro 2001). However, some species such as the sea star Pteraster tesselatus rely to a great extent on their mucus as chemical defense (Nance and Braithwaite Hwang et al (2011Hwang et al ( , 2014 Crude saponin Insecticide and repellant activity Park et al (2009) Asterosides A-D, glycoside B, asterosaponins n.d. Riccio et al (1988) Asterosaponin-4 Cytotoxic Okano et al (1985) Asterosaponin A, A 4 Antitumor Ikegami et al (1973) Asterias vulgaris 13 steroidal compounds n.d. Findlay and Agarwal (1983) Asterias forbesi Forbeside D n.d.…”

Section: Asteroids (Sea Stars)mentioning

confidence: 99%

Chemical Biodiversity and Bioactivities of Saponins in Echinodermata with an Emphasis on Sea Cucumbers (Holothuroidea)

Kamyab

Kellermann

Kunzmann

et al. 2019

YOUMARES 9 - The Oceans: Our Research, Our Future

View full text Add to dashboard Cite

Echinoderms are a source of a broad range of secondary metabolites with a large variety of bioactive properties. Although pigment and lipid derivatives are the major groups of bioactive compounds found in crinoids and ophiuroids, saponins represent the most abundant and diverse marine natural products (MNPs) in the phylum Echinodermata. This review is for researchers that are interested in MNPs derived from echinoderms, but with a particular focus on the structural diversity and biological function of saponins. Among the echinoderms, these steroidal compounds are mostly known for and structurally most diverse within sea cucumbers. Through compilation of extensive tables, this review provides a reference book, summarizing not only the major chemical classes of well-known secondary metabolites in the phylum Echinodermata but also further focusing on the presence of bioactive saponins in echinoderms in general and within different sea cucumber species in particular. The final compilation aims to correlate the vast structural diversity of saponins with known biological functions. The here presented data revealed that holothurians, holotoxins, cucumariosides, and echinosids are not only the most abundant saponin compounds in various genera of sea cucumbers but that these saponins can also be used as potential chemotaxonomic markers for different sea cucumber species. By studying the structure-function relationships of triterpene glycosides in echinoderms in general, or in particular within holothurians, the vast structural diversity, taxonomic distribution, and bioactivity of the molecules can be deciphered, which provides an opportunity to focus future research efforts on target species that contain MNPs with novel pharmacological activities.

show abstract

“…In addition, 15,000 tons of starfish are landed with other valuable species every year and treated as costly industrial waste in Hokkaido. On the other hand, this starfish contains bioactive compounds, such as astaxanthin 10 , saponin 11 , and eicosapentaenoic acid-rich phosphatidylcholine 12 . In particular, it comprises higher GlcCer amounts 0.7 of wet internal organ weight 13 than plant sources 14,15 .…”

Section: Introductionmentioning

confidence: 99%