Asthma

Lugogo, Njira L; Que, Loretta G.; Fertel, Daniel; Kraft, Monica

doi:10.1016/b978-1-4160-4710-0.00038-9

Cited by 5 publications

(5 citation statements)

References 450 publications

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“…Eosinophilic inflammation is most commonly associated with asthma, i.e. T2-high asthma phenotypes [ 2 , 51 , 52 ]; however, elements of eosinophilic inflammation have also been observed in COPD patients, and especially in those with concomitant asthma and COPD. Currently, peripheral eosinophilia guides escalation strategy of inhalation therapy in COPD patients in whom a tighter exacerbation control is indicated [ 5 , 21 , 24 ].…”

Section: Discussionmentioning

confidence: 99%

Investigating the role of obstructive pulmonary diseases and eosinophil count at admission on all-cause mortality in SARS-CoV-2 patients

Salai

Vražić

Kovačević

et al. 2023

Wien Klin Wochenschr

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Introduction The impact of asthma and chronic obstructive pulmonary disease (COPD) in the setting of severe acute respiratory syndrome coronavirus 2 (SARS-CoV‑2) infection is not clearly defined. Blood eosinophil count is a standard diagnostic test which, according to the previously published literature, might have a potential prognostic role on mortality in patients with SARS-CoV‑2 infection. Aim To investigate the potential prognostic value of peripheral blood eosinophil count on all-cause mortality of patients hospitalized with SARS-CoV‑2 infection, as well as to assess the impact of asthma or COPD premorbidity on all-cause mortality. Material and methods We conducted a retrospective registry-based cohort study. Survival analysis was performed by employing the Cox proportional hazards regression model at 30 days of follow-up. Prognostic value of eosinophil count on all-cause mortality was assessed using receiver-operating characteristic (ROC) curve analysis. Results A total of 5653 participants were included in the study. Our model did not reveal that pre-existing asthma or COPD is a statistically significant covariate for all-cause mortality but, indicated that higher eosinophil count at admission might have a protective effect (hazard ratio, HR 0.13 (95% confidence interval, CI 0.06–0.27), p = 0.0001). ROC curve analysis indicates cut-off value of 20 cells/mm 3 (81% specificity; 30.9% sensitivity). Conclusion Our results indicate that eosinophil count at hospital admission might have a potential prognostic role for all-cause mortality at 30 days of follow-up; however this was not demonstrated for pre-existing obstructive lung diseases.

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Section: Discussionmentioning

confidence: 99%

Investigating the role of obstructive pulmonary diseases and eosinophil count at admission on all-cause mortality in SARS-CoV-2 patients

Salai

Vražić

Kovačević

et al. 2023

Wien Klin Wochenschr

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“…This narrowing has been thought an occur disproportionately in the small bronchi 37 . Although recent studies suggest a prominent role for large and medium airways.…”

Section: Discussionmentioning

confidence: 99%

“…Although recent studies suggest a prominent role for large and medium airways. 37,38 As a result, lung function tests are abnormal, with an increase in airway resistance and a decline in maximal expiratory flow. 37 In obstructive lung conditions the airways are narrowed usually causing an increase in time it takes to empty the lungs.…”

Section: Discussionmentioning

confidence: 99%

Study on to assess pulmonary function test changes in asthmatic child using spirometry and its diagnostic and prognostic value

Patil¹,

Chavan²

2017

Int J Contemp Pediatr

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Background: Asthma is a disease that has become increasingly common over the last century making it now one of the commonest chronic disorders in the world. Spirometric lung function tests are playing a key role in the diagnosis and management of asthma in children. Considering the usefulness of spirometer in the diagnosis of asthma and scarcity of the literature regarding the role of spirometer in the diagnosis of Asthma especially in Indian context, the present study was undertaken to assess pulmonary function test changes in asthmatic child using spirometry and its diagnostic and prognostic value. Methods: The present study was conducted at Department of Paediatrics, Ashwini Rural Medical College, Hospital and Research Centre, Kumbhari during the study period of 2015 to 2016. Children presenting symptoms suggestive of asthma were included in the study. Results: In the present study, the commonest presentations included cough, breathing difficulty and recurrent wheeze in all the children (100%) followed by chest tightness (23%) and fever (11%). In the present study, the clinical and spirometry diagnosis of moderate asthma showed total positive correlation (100%). The positive correlation of mild persistent and intermittent asthma was limited to 97.30% and 91.18%. Severe persistent asthma positively correlated in 76.77%. Conclusions: It may be concluded that, the spirometry is not only helps to diagnose the asthma accurately, but also helps in assessing the severity which has the key role in the successful management.

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“…Asthma has been shown to have prevalence of 7-10% world-wide[ 1 ] and 9% in Malta[ 2 ] and is a common cause of emergency room visits. [ 3 ] Asthma exacerbations require prompt evaluation and treatment to limit morbidity and mortality. [ 3 ] Recent studies reveal that management of adult asthma in the accident and emergency (A&E) department setting often differs from that which is recommended in clinical practice guidelines.…”

Section: Introductionmentioning

confidence: 99%

“…[ 3 ] Asthma exacerbations require prompt evaluation and treatment to limit morbidity and mortality. [ 3 ] Recent studies reveal that management of adult asthma in the accident and emergency (A&E) department setting often differs from that which is recommended in clinical practice guidelines. [ 4 ] Common problems include poor adherence to published guidelines, inadequate assessment and recognition of severity and confusion over the use and interpretation of investigations.…”

Section: Introductionmentioning

confidence: 99%

A local perspective to asthma management in the accident and emergency department in Malta

et al. 2013

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Aim:This study was performed to assess the management of adult patients presenting to the Mater Dei Hospital Accident and Emergency (A&E) department with acute asthma.Subjects and Methods:Asthmatic patients age 14 or older who presented to A&E department between January and October 2010 with asthma exacerbations were included. Data were collected from the clinical notes and analyzed.Results:A total of 244 patients (67.2% females) were included, 126 (51.6%) were admitted, 97 (39.8%) discharged and 21 (8.6%) discharged themselves against medical advice. There was a decline in the presentations between January and July, followed by an upward trend until October (P = 0.42). Pulse oximetry was performed in 207 patients (84.8%), arterial blood gases in 133 (54.5%), peak expiratory flow rate in 106 (43.4%) and chest radiography in 206 (84.4%) patients. The respiratory rate was documented in 151 (61.8%), heart rate in 204 (83.6%) and ability to complete sentences in 123 (50.4%) patients. One hundred and ninety six patients (80.3%) were given nebulized bronchodilators, 103 (42.2%) intravenous corticosteroids, 7 (2.87%) oral corticosteroids, 109 (44.7%) oxygen, 28 (11.5%) antibiotics and 9 (3.69%) magnesium. Systemic corticosteroids and antibiotics were more commonly prescribed to patients admitted (P < 0.001).Conclusion:Management of acute asthma in Malta requires optimization in order to compare with international guidelines.

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Asthma

Cited by 5 publications

References 450 publications

Investigating the role of obstructive pulmonary diseases and eosinophil count at admission on all-cause mortality in SARS-CoV-2 patients

Investigating the role of obstructive pulmonary diseases and eosinophil count at admission on all-cause mortality in SARS-CoV-2 patients

Study on to assess pulmonary function test changes in asthmatic child using spirometry and its diagnostic and prognostic value

A local perspective to asthma management in the accident and emergency department in Malta

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