Asthma and atopic dermatitis after early‐, late‐, and post‐term birth

Korhonen, Päivi; Haataja, Paula; Ojala, Riitta; Hirvonen, Mikko; Korppi, Matti; Paassilta, Marita; Uotila, Jukka; Gissler, Mika; Luukkaala, Tiina; Tammela, Outi

doi:10.1002/ppul.23942

Cited by 17 publications

(18 citation statements)

References 39 publications

(92 reference statements)

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“…In our study, there was an association between reported asthma/asthma like symptoms and increased gestational age at delivery, but not for other factors such as mode of delivery, child's use of antibiotic medication in the past year of child's stay at the neonatal intensive care unit after birth. While early-term birth is a predictor of asthma, late term birth has also been associated with atopic dermatitis by 7 years of age 90 . Atopic dermatitis often precedes other allergic diseases such as asthma 91 , however, given the cross sectional nature of our study, we are limited in discussing this topic.…”

Section: Discussionmentioning

confidence: 99%

Reported neighborhood traffic and the odds of asthma/asthma like symptoms: a cross-sectional analysis of a multi-racial cohort of children

Commodore

Ferguson

Neelon

et al. 2020

Preprint

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Background: Respiratory symptoms and asthma in children pose a significant clinical and public health burden. Our aim was to examine exposures to environmental air pollution in relation to asthma and related symptoms in a multi-racial cohort of children. Methods: We conducted a cross-sectional analysis evaluating the association between reported neighborhood traffic (a proxy for traffic-related air pollution) and asthma among 855 children aged 4 to 8 years old who participated in the Environmental Influences on Child Health Outcomes (ECHO) cohort. The primary outcome, asthma/asthma like symptoms (defined as current and/or past physician diagnosed asthma, past wheezing, or nighttime cough or wheezing in the past 12 months), was assessed by parental report via questionnaire. The relationship between the primary exposure and asthma/asthma like symptoms was examined using logistic regression. Results: The prevalence of asthma/asthma like symptoms was 23%. Fifteen percent of parents responded “Agree” or “Strongly Agree” to the question, “There is so much traffic along the streets that it makes it difficult or dangerous to walk with my child in my neighborhood” (n=129/855). Children whose parents had affirmed significant neighborhood traffic had a higher odds of having asthma/asthma like symptoms than children without significant neighborhood traffic [adjusted OR=1.78 (95% CI: 1.10, 2.88)] after controlling for child’s race-ethnicity, age, sex, maternal education level, family history of asthma, presence of play equipment in the home environment, public parks in the neighborhood and obesity. Other factors significantly associated with asthma/asthma like symptoms were: non-Hispanic Black and Hispanic race/ethnicity [OR=2.53 (95% CI: 1.43, 4.50)] and [OR=2.25 (95% CI: 1.28, 3.94), respectively, vs. non-Hispanic White referent], play equipment in the home environment or backyard [OR=1.60 (95% CI: 1.09, 2.35)], obese status [OR=2.54 (95% CI: 1.55, 4.17)], male sex [OR=1.53 (1.06, 2.22)] and family history of asthma [OR=3.19 (2.20, 4.64)]. Conclusions: Reported neighborhood traffic, non-Hispanic Black and Hispanic race/ethnicity, male sex, play equipment within the home environment, obesity, and family history of asthma were associated with greater odds for asthma/asthma like symptoms. Further characterization of neighborhood traffic patterns is needed, since many children live near this source of environmental air pollution and significant racial/ethnic disparities exist.

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Section: Discussionmentioning

confidence: 99%

Reported neighborhood traffic and the odds of asthma/asthma like symptoms: a cross-sectional analysis of a multi-racial cohort of children

Commodore

Ferguson

Neelon

et al. 2020

Preprint

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“…5,6 A few recent studies have suggested that early-term birth is associated with later respiratory morbidity such as asthma, 4,7,8 whereas post-term birth may decrease the risk of asthma. [9][10][11] Less information is available on the long-term respiratory infectious morbidity of children born early-term and post-term. Lower respiratory tract infections (LRTIs) are the leading cause of hospitalisation in preschool children and result in a remarkable burden on health services.…”

Section: Backg Rou N Dmentioning

confidence: 99%

“…Post‐term birth has also been associated with an increased risk of adverse neonatal outcomes compared with full‐term birth . A few recent studies have suggested that early‐term birth is associated with later respiratory morbidity such as asthma, whereas post‐term birth may decrease the risk of asthma . Less information is available on the long‐term respiratory infectious morbidity of children born early‐term and post‐term.…”

Section: Introductionmentioning

confidence: 99%

Hospital admissions for lower respiratory tract infections after early‐, late‐, and post‐term birth

Haataja

Korhonen

Ojala

et al. 2020

Paediatric Perinatal Epid

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Background Recent data suggest that early‐term births are associated with later respiratory morbidity (LRTI), and post‐term births may decrease this risk. Objectives The objective was to determine the impact of early‐term, late‐term, and post‐term birth on hospital admission for LRTI up to the age of seven years. Additionally, we explored maternal and perinatal factors associated with the risk of admission for LRTIs. Methods The association of early‐term (37+0‐38+6 weeks), late‐term (41+0‐41+6 weeks), and post‐term (≥42 weeks) birth with hospital admissions for lower respiratory tract infections (LRTI) in comparison with infants born full‐term (39+0‐40+6 weeks) was assessed and early predictors of LRTI were established. The register study included 948 695 infants born in Finland in 1991‐2008. Data were analysed in four‐term subgroups. Hospital admissions for bronchiolitis/bronchitis and pneumonia were collected up to 7 years of age. Adjusted Cox proportional hazards models were used to assess risk factors of LRTI admissions. Results The rates of hospital admission in the early‐, full‐, late‐, and post‐term groups were 6.7%, 5.5%, 5.1%, and 4.8% for bronchiolitis/bronchitis, and 2.8%, 2.4%, 2.3%, and 2.3% for pneumonia. Early‐term birth was associated with an increased risk of admission for bronchiolitis/bronchitis (hazard ratio HR 1.21, 95% confidence interval CI 1.18, 1.23) and pneumonia (HR 1.16, 95% CI 1.12, 1.20), while late‐term (HR 0.93, 95% CI 0.91, 0.95) and post‐term births (HR 0.89, 95% CI 0.85, 0.93) were associated with a decreased risk of bronchiolitis/bronchitis admission compared with the full‐term group. Maternal age ≤ 20 years, smoking during pregnancy, male sex, caesarean delivery, small for gestational age, 1‐minute Apgar score < 4, ventilator support, and neonatal antibiotic therapy were associated with an increased risk of LRTI admission, while being firstborn, born in a level‐II hospital and in the Northern region was associated with decreased risk. Conclusion Early‐term birth was associated with a higher risk of all LRTI admissions while late‐term and post‐term births were associated with lower risk of bronchiolitis/bronchitis admission. Modifiable risk factors of LRTIs were smoking during pregnancy, birth by elective caesarean delivery, neonatal ventilator support, and antibiotic therapy.

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“…Gestational age is associated with asthma especially in preterm infants; Korhonen et al investigated this association in over 960,000 infants focusing on exposures in the post‐term period. They found the most important risk factors for asthma at 7 years age were male sex, atopic dermatitis, intrauterine tobacco smoke exposure, early term birth, and elective cesarean section.…”

Section: Introductionmentioning

confidence: 99%

Pediatric Pulmonology year in review 2018: Asthma, physiology/pulmonary function testing, and respiratory infections

Loughlin

Muston

et al. 2019

Pediatric Pulmonology

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Pediatric Pulmonology publishes original research, reviews, and case reports related to a wide range of children's respiratory disorders. In our “Year in Review” series, we summarize publications in our major topic areas from 2018, in the context of selected literature in these areas from other journals relevant to our discipline. This review covers selected articles on asthma, physiology/lung function testing, and respiratory infections.

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Asthma and atopic dermatitis after early‐, late‐, and post‐term birth

Abstract: Early-term birth was a predictor of asthma, and PT birth was associated with atopic dermatitis. Counseling against smoking and following strict indications for planned ET deliveries and cesarean sections may be means to reduce the risk of later asthma.

Cited by 17 publications

References 39 publications

Reported neighborhood traffic and the odds of asthma/asthma like symptoms: a cross-sectional analysis of a multi-racial cohort of children

Reported neighborhood traffic and the odds of asthma/asthma like symptoms: a cross-sectional analysis of a multi-racial cohort of children

Hospital admissions for lower respiratory tract infections after early‐, late‐, and post‐term birth

Pediatric Pulmonology year in review 2018: Asthma, physiology/pulmonary function testing, and respiratory infections

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