Asthma and bacterial sinusitis in children

Friedman, Roger; Ackerman, Michael H.; Wald, Ellen R.; Casselbrant, Margaretha L.; Friday, Gilbert A.; Fireman, Philip

doi:10.1016/0091-6749(84)90284-7

Cited by 153 publications

(36 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…On the other hand, respiratory tract infections seem to exacerbate established asthma and contribute to asthma chronicity [5,6]. These infections, even though originally defined of viral origin, often involve mixed bacterial co-infection and several types of bacterial infections have been associated with acute asthma exacerbations or chronic stable asthma [6,7]. Eosinophils have been suggested to play an important role in asthma exacerbations [8,9].…”

Section: Introductionmentioning

confidence: 99%

Bacterial DNA delays human eosinophil apoptosis

Ilmarinen¹,

Hasala²,

Sareila³

et al. 2009

Pulmonary Pharmacology & Therapeutics

View full text Add to dashboard Cite

To cite this version:Pinja Ilmarinen, Hannele Hasala, Outi Sareila, Eeva Moilanen, Hannu Kankaanranta. Bacterial DNA delays human eosinophil apoptosis. Pulmonary Pharmacology & Therapeutics, 2009, 22 (3), pp.167. <10.1016/j.pupt.2008.11.012>. Please cite this article as: Ilmarinen P, Hasala H, Sareila O, Moilanen E, Kankaanranta H. Bacterial DNA delays human eosinophil apoptosis, Pulmonary Pharmacology & Therapeutics (2008), doi: 10.1016/j.pupt.2008 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. ODNs had occasionally parallel but less profound effect on eosinophil apoptosis, which was not dependent on endosomal acidification. The anti-apoptotic effect of CpG AcceptedODNs was dependent on phosphatidylinositol 3-kinase (PI3K) and nuclear factor-κB (NF-κB) but not mitogen-activated protein kinases (MAPKs) as determined by inhibitor studies. Although our results suggest CpG-dependent involvement of TLR9 in the action of phosphorothioate-modified ODNs, we interestingly found that the antiapoptotic action of native bacterial DNA in eosinophils is not dependent on unmethylated CpG motifs. This suggests that bacterial DNA contains a currently unknown recognition structure lacking from vertebrate DNA. Bacterial DNA-mediated suppression of eosinophil apoptosis is a novel mechanism for exacerbation of eosinophilic lung inflammation associated with bacterial respiratory tract infection.

show abstract

Section: Introductionmentioning

confidence: 99%

Bacterial DNA delays human eosinophil apoptosis

Ilmarinen¹,

Hasala²,

Sareila³

et al. 2009

Pulmonary Pharmacology & Therapeutics

View full text Add to dashboard Cite

show abstract

“…No conclusive evidence is available from the literature either, but there are a few studies showing that the patients with a difficult-to-control asthma will improve when co existing sinusitis is treated medically and/or surgically. Friedman et al [16] reported that 7 of the 8 patients with exacerbation of asthma and coexistent sinusitis improved clinically and both asthma symptoms and pulmonary func tion tests improved in 5 of them after antibiotic treatment of 14-28 days. Also Rachelefsky et al [17] demonstrated that children with both asthma and sinusitis show signif icant improvement of asthma when they receive appropri ate medical treatment for their sinusitis.…”

Section: Discussionmentioning

confidence: 99%

Sinus Aspirates and Radiographic Abnormalities in Severe Attacks of Asthma

Rossi

Pirilä

Laitinen

et al. 1994

Int Arch Allergy Immunol

View full text Add to dashboard Cite

We evaluated the occurrence of abnormalities in paranasal sinus radiographs in acute asthma by taking a radiograph of the sinuses of 110 consecutive patients admitted to a medical ward a total of 149 times for asthma. Maxillary sinus infection was assessed by taking aspirate from radiologically abnormal maxillary sinuses. An abnormal finding in any paranasal sinus was detected on 87% (130 of 149) of admissions and the yield of maxillary aspirate was macroscopically mucous purulent or mucopurulent in 60% (42 of 70) of aspirates. A positive bacteriological culture was obtained from 23 aspirates and a virus was detected in 15, there being 7 aspirates in which both a bacterium and a virus could be detected. Although the correlation between radiographic findings and the aspirates was not very close we conclude that radiographic abnormalities of the paranasal sinuses are common in acute asthma as are infections of maxillary sinuses with an abnormal radiographic finding. There is an obvious need to look for sinusitis when a patient with an exacerbation of asthma is being evaluated.

show abstract

“…[17][18][19][20] The following plain radiograph projections of the PNS were reported by the researchers and a two consultant radiologists on a viewing box (kenex-Electro medical Hd, Essex, England): occipitofrontal view (caldwell view), occipitomental view (waters view) and lateral view. The occipitofrontal view was used to evaluate the frontal and ethmoid sinuses, the occipitomental view was used to evaluate the maxillary sinus and the lateral view was used to evaluate the sphenoid sinus.…”

Section: Exclusion Criteriamentioning

confidence: 99%

Chronic rhinosinusitis: the correlation between symptom severity score and findings on plain radiographs of the paranasal sinuses

Idugboe

Otoghile

Musa³

et al. 2017

Int J Otorhinolaryngol Head Neck Surg

View full text Add to dashboard Cite

Background: Chronic rhinosinusitis (CRS) is a common clinical problem with often refractory symptoms. Though computed tomography scan of the paranasal sinuses (PNS) is the radiological gold standard for confirming the diagnosis of CRS, it is not readily available and affordable in developing countries. Hence plain radiographs are heavily relied upon to confirm the diagnosis of CRS. The reliability and adequacy of plain sinus radiographs in combination with disease specific questionnaires in the management of CRS is still debatable. The objectives of the study were to determine the correlation between symptom severity score and findings on plain radiograph of the PNS in adult patients with CRS.Methods: This was an eight month prospective cross sectional study (April-November, 2014) of Fifty- two consecutive newly diagnosed adult patients with CRS. Results: Age of patients ranged from 19–91 years. Male to female ratio was 1:1.26. There was significant positive correlation between high and moderate symptom severity score (severe and moderate disease) with findings on plain radiograph of the PNS (p=0.032 and 0.048 respectively).Conclusions: The overall symptom severity score of CRS correlates with findings on the plain radiographs of patients with CRS especially in severe and moderate disease.

show abstract

Asthma and bacterial sinusitis in children

Cited by 153 publications

References 13 publications

Bacterial DNA delays human eosinophil apoptosis

Bacterial DNA delays human eosinophil apoptosis

Sinus Aspirates and Radiographic Abnormalities in Severe Attacks of Asthma

Chronic rhinosinusitis: the correlation between symptom severity score and findings on plain radiographs of the paranasal sinuses

Contact Info

Product

Resources

About