Asthma and gastroesophageal reflux: Acid suppressive therapy improves asthma outcome

Harding, Susan M.; Richter, Joel E.; Guzzo, Melany R.; Schan, Cathy A.; Alexander, Robert W.; Bradley, Laurence A.

doi:10.1016/s0002-9343(97)89514-9

Cited by 355 publications

(177 citation statements)

References 24 publications

Supporting

Mentioning

152

Contrasting

Unclassified

Order By: Relevance

“…Empirical treatment for patients without typical symptoms or objective evidence of GERD thus cannot be routinely recommended. Th e historic recommendation is to treat patients with higher dose PPI (twice daily) than patients with typical GERD symptoms; however, this is based on uncontrolled and observational data only ( 143,144 ). Patients who are treated with PPI and who do not respond to a 2 -3 month course of acid suppression can be evaluated and managed as proposed in the " refractory GERD " section.…”

Section: Summary Of the Evidencementioning

confidence: 99%

Guidelines for the Diagnosis and Management of Gastroesophageal Reflux Disease

Katz¹,

Gerson²,

Vela³

2013

American Journal of Gastroenterology

1,553

1,430

View full text Add to dashboard Cite

Section: Summary Of the Evidencementioning

confidence: 99%

Guidelines for the Diagnosis and Management of Gastroesophageal Reflux Disease

Katz¹,

Gerson²,

Vela³

2013

American Journal of Gastroenterology

1,553

1,430

View full text Add to dashboard Cite

“…is sufficient to effectively stop acid reflux in 73% of asthmatics with GOR, while omeprazole 40 mg . day -1 was effective in 93% of patients [30]. It is likely that gastric symptoms were not significantly relieved during the omeprazole treatment among the other subgroup of patients because of their low baseline symptom score (2/63) rather than an insufficient dose of omeprazole.…”

Section: Discussionmentioning

confidence: 95%

Chronic cough and gastro-oesophageal reflux: a double-blind placebo-controlled study with omeprazole

Kiljander¹,

Salomaa²,

Hietanen³

et al. 2000

Eur Respir J

137

105

View full text Add to dashboard Cite

Gastro-oesophageal reflux (GOR) is an important cause of chronic cough. There has been a lack of placebo-controlled trials treating GOR related chronic cough with antireflux therapy. The aim of this study was to determine the efficacy of omeprazole on GOR related chronic cough.After excluding other common causes of cough, oesophageal pH monitoring was performed on 48 patients with chronic cough. Twenty-nine patients found to have GOR were randomized in a double-blind fashion to receive omeprazole 40 mg o.d. or placebo for 8 weeks. After a 2-week washout period, patients were crossed over to the other treatment. Symptoms were recorded daily in a diary.Twenty-one patients completed both treatment periods. Cough (p=0.02) and gastric symptoms (p=0.003) improved significantly during the omeprazole treatment in twelve patients who received placebo during the first and omeprazole during the second 8-week period. In nine patients who received omeprazole during the first 8-week period, amelioration in cough reached statistical significance only after cessation of omeprazole. Gastric symptoms also remained minor during placebo in these nine patients.Omeprazole 40 mg o.d. seems to improve chronic cough in patients with gastrooesophageal reflux and the effect of omeprazole in ameliorating both cough and reflux symptoms continues after treatment ceases. Eur Respir J 2000; 16: 633±638.

show abstract

“…Prevalence of GERD in asthmatics was documented to be as high as 34%− 80% [8,9] compared with subjects without GERD where it is 5%−10% [16]. Previous studies have shown that GERD is a factor that can worsen asthma control [16][17][18][19][20][21]. This can be explained by 3 processes, including increased vagal tone, heightened bronchial reactivity, and microaspiration of gastric content.…”

Section: Discussionmentioning

confidence: 99%

“…Esomeprazole 40 mg twice daily may improve pulmonary function (FEV 1 ) and asthmarelated quality of life [14]. Harding et al [19] studied 30 asthmatic patients with GERD and showed that using omeprazole 40 mg/day for 12 weeks, did not result in improvement in any of the parameters including daytime symptoms, night-time symptoms, PEF, and FEV 1 . Kiljander et al [24] studied 322 asthmatic patients with GERD and showed that esomeprazole 80 mg/day for 16 weeks resulted in significant improvement in PEF only in patients who had night-time symptoms.…”

Section: Discussionmentioning

confidence: 99%

Observational study of omeprazole for gastroesophageal reflux on pulmonary function in adult asthmatics

et al. 2015

View full text Add to dashboard Cite

Background: Asthma is a chronic inflammatory disease of airways. Gastroesophageal reflux disease (GERD) is known to be associated with worsening asthma. We hypothesized that treatment of GERD in asthmatics will improve asthma control and quality of life. We reviewed our experience of treatment of GERD in asthmatics in Thailand. Objectives: To study the effects of omeprazole for treatment of GERD in patients with poorly controlled asthma on pulmonary function tests and asthma control test (ACT) scores. Methods: This study was conducted at King Chulalongkorn Memorial Hospital between August 2009 and December 2010. Patients with partly controlled and uncontrolled asthma who were found to have GERD by 24 hour esophageal pH monitoring were administered omeprazole 40 mg per day for 8 weeks. Pulmonary function tests and ACT scores before and after treatment were compared at 4-weeks and 8-weeks follow up. Results: Twenty four patients were included in this study. None of them had asthmatic attacks during the study. After 4 and 8 weeks of omeprazole treatment, the mean FEV1 (2.20 ± 0.64 L, 2.36 ± 0.58 L, respectively) and the mean ACT score (20.82 ± 3.30, 23.00 ± 1.69, respectively) were significantly higher than the pretreatment values (mean FEV1 1.99 ± 0.56 L and ACT score 16.36 ± 3.97) (P < 0.05). Conclusion: High-dose omeprazole may improve pulmonary function and the level of asthma control in Thai patients with partly controlled or uncontrolled asthma and coexisting GERD.

show abstract

Asthma and gastroesophageal reflux: Acid suppressive therapy improves asthma outcome

Cited by 355 publications

References 24 publications

Guidelines for the Diagnosis and Management of Gastroesophageal Reflux Disease

Guidelines for the Diagnosis and Management of Gastroesophageal Reflux Disease

Chronic cough and gastro-oesophageal reflux: a double-blind placebo-controlled study with omeprazole

Observational study of omeprazole for gastroesophageal reflux on pulmonary function in adult asthmatics

Contact Info

Product

Resources

About