Asthma and Lung Function 20 Years After Wheezing in Infancy

Piippo-Savolainen, Eija; Remes, Sami; Kannisto, Senja; Korhonen, Kaj; Korppi, Matti

doi:10.1001/archpedi.158.11.1070

Cited by 103 publications

(169 citation statements)

References 33 publications

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“…They comprised 6 birth cohorts [17][18][19][20][21][22] and 19 population-based longitudinal studies. [12,13,[23][24][25][26][27][28][29][30][31][32][33][34][35][36][37][38][39] Tables 1 and 2 give an overview of the included studies. The reasons for rejecting the remaining 30 papers [9,10, are summarised in Table 3.…”

Section: Resultsmentioning

confidence: 99%

“…Two combinations which included early childhood infection had very wide confidence intervals (ID 43 & 45) suggesting there were other unexplored confounding factors contributing to the observed differences. In some studies early respiratory viral infections have been associated with the subsequent development of asthma [23,32,34,36] but not in others. [40,74] It has been suggested that RV infections in early life are more likely to cause reduced lung function than RSV infections.…”

Section: Page 13 Of 24mentioning

confidence: 99%

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A systematic review of early life factors which adversely affect subsequent lung function

Kouzouna

Gilchrist

Ball

et al. 2016

Paediatric Respiratory Reviews

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It has been known for many years that multiple early life factors can adversely affect lung function and future respiratory health. This is the first systematic review to attempt to analyse all these factors simultaneously. We adhered to strict a priori criteria for inclusion and exclusion of studies.The initial search yielded 29,351 citations of which 208 articles were reviewed in full and 25 were included in the review. This included 6 birth cohorts and 19 longitudinal population studies. The 25 studies reported the effect of 74 childhood factors (on their own or in combinations with other factors) on subsequent lung function reported as percent predicted forced expiration in one second (FEV 1 ). The childhood factors that were associated with a significant reduction in future FEV 1 could be grouped as: early infection, bronchial hyper-reactivity (BHR) / airway lability, a diagnosis of asthma, wheeze, family history of atopy or asthma, respiratory symptoms and prematurity / low birth weight. A complete mathematical model will only be possible if the raw data from all previous studies is made available. This highlights the need for increased cooperation between researchers and the need for international consensus about the outcome measures for future longitudinal studies.

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Section: Resultsmentioning

confidence: 99%

Section: Page 13 Of 24mentioning

confidence: 99%

A systematic review of early life factors which adversely affect subsequent lung function

Kouzouna

Gilchrist

Ball

et al. 2016

Paediatric Respiratory Reviews

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“…Ongoing birth cohort studies should be able to provide information on the outcome in general populations during the 2010s. Considering more severe early wheeze, half of the children hospitalised with acute wheeze before the age of 2 yrs were symptom-free by the age of 5 yrs and 70% by 10 yrs, but only 57% by 17-20 yrs [44][45][46], illustrating the tendency for relapse during adolescence. Female sex, passive smoking during infancy and early sensitisation to allergens were risk factors for symptoms continuing into early adulthood, but type of virus and premature birth were not.…”

Section: Multiple-trigger Wheezementioning

confidence: 99%

Definition, assessment and treatment of wheezing disorders in preschool children: an evidence-based approach

Brand¹,

Baraldi²,

Bisgaard³

et al. 2008

Eur Respir J

750

759

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There is poor agreement on definitions of different phenotypes of preschool wheezing disorders. The present Task Force proposes to use the terms episodic (viral) wheeze to describe children who wheeze intermittently and are well between episodes, and multiple-trigger wheeze for children who wheeze both during and outside discrete episodes. Investigations are only needed when in doubt about the diagnosis.Based on the limited evidence available, inhaled short-acting b 2 -agonists by metered-dose inhaler/spacer combination are recommended for symptomatic relief. Educating parents regarding causative factors and treatment is useful. Exposure to tobacco smoke should be avoided; allergen avoidance may be considered when sensitisation has been established. Maintenance treatment with inhaled corticosteroids is recommended for multiple-trigger wheeze; benefits are often small. Montelukast is recommended for the treatment of episodic (viral) wheeze and can be started when symptoms of a viral cold develop.Given the large overlap in phenotypes, and the fact that patients can move from one phenotype to another, inhaled corticosteroids and montelukast may be considered on a trial basis in almost any preschool child with recurrent wheeze, but should be discontinued if there is no clear clinical benefit.Large well-designed randomised controlled trials with clear descriptions of patients are needed to improve the present recommendations on the treatment of these common syndromes.

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“…14% to 40% of bronchiolitis patients will eventually have asthma [25,196], with the association persisting into adulthood [196][197][198][199][200][201][202][203]. In young children, asthma is heralded by acute bronchiolitis in 90% of cases, one third of which require hospitalization [204].…”

Section: Predicting Whether a Bronchiolitis Patient Will Later Be Diamentioning

confidence: 99%

A systematic review of predictive modeling for bronchiolitis

Luo

Nkoy

Gesteland

et al. 2014

International Journal of Medical Informatics

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Purpose: Bronchiolitis is the most common cause of illness leading to hospitalization in young children. At present, many bronchiolitis management decisions are made subjectively, leading to significant practice variation among hospitals and physicians caring for children with bronchiolitis. To standardize care for bronchiolitis, researchers have proposed various models to predict the disease course to help determine a proper management plan. This paper reviews the existing state of the art of predictive modeling for bronchiolitis. Predictive modeling for respiratory syncytial virus (RSV) infection is covered whenever appropriate, as RSV accounts for about 70% of bronchiolitis cases.Methods: A systematic review was conducted through a PubMed search up to April 25, 2014. The literature on predictive modeling for bronchiolitis was retrieved using a comprehensive search query, which was developed through an iterative process.Search results were limited to human subjects, the English language, and children (birth-18 years). Results:The literature search returned 2,312 references in total. After manual review, 168 of these references were determined to be relevant and are discussed in this paper. We identify several limitations and open problems in predictive modeling for bronchiolitis, and provide some preliminary thoughts on how to address them, with the hope to stimulate future research in this domain. Conclusions:Many problems remain open in predictive modeling for bronchiolitis. Future studies will need to address them to achieve optimal predictive models.

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Asthma and Lung Function 20 Years After Wheezing in Infancy

Abstract: The increased risk for asthma persists until adulthood after bronchiolitis in infancy.

Cited by 103 publications

References 33 publications

A systematic review of early life factors which adversely affect subsequent lung function

A systematic review of early life factors which adversely affect subsequent lung function

Definition, assessment and treatment of wheezing disorders in preschool children: an evidence-based approach

A systematic review of predictive modeling for bronchiolitis

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