Asthma and metabolic syndrome: Clinical and pathogenetic relationships

Budnevsky, A. V.; Malysh, E Yu; Ovsyannikov, Evgeniy; Дробышева, Елена Сергеевна

doi:10.17116/terarkh20158710110-114

Cited by 7 publications

(4 citation statements)

References 31 publications

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“…Patients with comorbid COPD and CHF are in a state of prolonged hypoxia: permanent (chronic respiratory failure) or intermittent [9,10,11]. Intermittent hypoxia can occur during exercise, exacerbation of COPD or CHF decompensation and during sleep.…”

Section: Discussionmentioning

confidence: 99%

Physical Rehabilitation in Patients with Chronic Heart Failure and Chronic Obstructive Pulmonary Disease

Tokmachev¹,

Budnevsky²,

Kravchenko³

et al. 2022

PJMHS

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Despite all the efforts of medical services, the socio-economic damage caused by chronic heart failure (CHF) is increasing. Approximately 10-40% of patients with CHF also suffer from chronic obstructive pulmonary disease (COPD). The comorbid course of these pathologies aggravates the prognosis of patients. Moderate physical activity is recommended as a non-drug therapy for both pathologies. The aim of the study: was to evaluate the effectiveness of physical rehabilitation in patients with chronic heart failure and chronic obstructive pulmonary disease by determining the levels of NT-proBNP, high-sensitivity C-reactive protein, IL-1β, IL-6, TNF-α. Methods: The study included 240 patients with CHF. After the initial examination, the patients were divided into groups depending on the presence or absence of COPD and the value of LVEF. Subsequently, each group was divided into a subgroup that took part in physical rehabilitation in addition to standard medical therapy and another one consist of patients that received only standard therapy. A year later, the levels of NT-proBNP, high-sensitivity C-reactive protein, IL-1β, IL-6 and TNF-α were re-determined. Results and Conclusion: CHFpEF patients have higher levels of hs-CRP and pro-inflammatory cytokines compared to patients with CHFrEF. The combination of COPD and CHF enhances systemic inflammation and myocardial remodeling processes, determined by the level of NT-proBNP in comparison with the isolated course of CHF. Physical rehabilitation in patients with a comorbid course of COPD and CHF is accompanied by a significant decrease in the levels of pro-inflammatory cytokines, hs-CRP and NT-proBNP. Keywords: chronic heart failure, chronic obstructive pulmonary disease, physical rehabilitation

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Section: Discussionmentioning

confidence: 99%

Physical Rehabilitation in Patients with Chronic Heart Failure and Chronic Obstructive Pulmonary Disease

Tokmachev¹,

Budnevsky²,

Kravchenko³

et al. 2022

PJMHS

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“…Bronchial asthma (BA) is a heterogeneous disease characterized by chronic inflammation of the airways, the presence of respiratory symptoms such as wheezing, shortness of breath and cough that vary in time and intensity [1][2][3]. According to World Health Organization in 2016 up to 339 million people of all ages worldwide suffered from the disease.…”

Section: Introductionmentioning

confidence: 99%

Physical Activity and Life Quality in Patients with Asthma and Osteoarthritis

Ivanchuk¹,

Трибунцева²,

Budnevsky³

et al. 2021

PJMHS

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Background. Physical activity is associated with better asthma control and life quality in asthma. Osteoarthritis is one of the less studied comorbidities in asthmatic patients. Methods. The study included 38 patients diagnosed with asthma, 65 patients with asthma and osteoarthritis, and 40 volunteers who did not suffer from asthma and osteoarthritis. During the study, 3 groups were formed: Group 1 consisted of patients with asthma; Group 2 included patients with both asthma and osteoarthritis, Control group consisted of volunteers. Spirometry, Asthma Quality of Life Questionnaire (AQLQ), Asthma Control Test (АСТ) were used in asthmatic patients. International Physical Activity Questionnaire (IPAQ) in its short from was filled by all the participants. Results. Both Group 1 and Group 2 did not engage in vigorous physical activity. Median of MET-min/week total (1825) was significantly less in Group 2 compared with Control and Group 1 (p=0.0000 and p=0.0169, respectively). MET-min/week total had positive correlations with ACT (r=0.50, p<0.05), AQLQ(S) total (r=0.58, p<0.05), AQLQ(S) activity domain (r=0.28, p<0.05), AQLQ(S) emotions domain (r=0.24, p<0.05), AQLQ (S) symptoms domain (r=0.34, p<0.05), FVC (r=0,28, p<0.05), FEV1 (r=0,37, p<0.05), Index Tiffno (r=0,18, p<0.05). Minutes/week sitting time had a negative correlation with ACT values (r=-0.33, p<0.05), AQLQ(S) total values (r=-0.39, p<0.05). Conclusion. Patients with asthma and osteoarthritis spend significantly less time on moderate activity, walking compared with asthmatics not suffering from osteoarthritis; they avoid vigorous activity. Higher physical activity is associated with better life quality, asthma control and lung function, thus paying attention to osteoarthritis in asthmatic patients is crucial. Key words: life quality, physical activity, asthma, osteoarthritis

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“…It is the heterogeneity of the disease that dictates the need for the most individualized treatment. (1,2) The heterogeneity of both clinical manifestations of asthma and response to therapy is considered nowadays. (3,4) We distinguish many asthma phenotypes, and even subphenotypes, based on those factors.…”

Section: Introductionmentioning

confidence: 99%

Clinical Phenotype “Obesity-Asthma” as One of the Main Problems of Personalized Pulmonology

Tribuntceva¹,

Shkatova²,

Авдеев³

et al. 2019

IJBM

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Background: Asthma is a heterogeneous disease comprising different phenotypes. One of the most common asthma phenotypes is the obesity-asthma phenotype, since obesity affects over a third of the world's population today. It is important to continue investigating possible underlying mechanisms of the interaction between asthma and obesity. The purpose of this study was to evaluate levels of leptin, adiponectin, neuropeptide Y (NPY), total oxidative damage (TOD), and total antioxidant status (TAS) in patients with asthma and different body weight (BW), and to analyze their association with spirometry parameters. Materials and Methods: The study included 27 men and 86 women diagnosed with moderate asthma (mean age of 57.81±13.05 years). During the study, all asthma patients were divided into 3 groups. Group 1 included 37 patients with normal BW, Group 2 included 38 overweight patients, and Group 3 included 38 patients with obesity. We analyzed complaints, anamnesis data, objective status data, and laboratory (blood levels of NPY, adiponectin, leptin, total antioxidant status, and total oxidative damage) and instrumental data (spirometry). Two questionnaires were used: Asthma Quality of Life Questionnaire (AQLQ) and Asthma Control Test (АСТ). Results: The leptin level was significantly higher in Group 3 compared to Groups 1 and 2 (P=0.000). The NPY level was significantly lower in Group 1 compared to Groups 2 and 3 (P=0.000). The TAS value was significantly higher in Group 1 compared to Groups 2 and 3 (P=0.000) and the TOD value in Group 1 was significantly lower than in Group 3 (P=0.038).The leptin level positively correlated with BMI and waist circumference, and had an inverse correlation with FEV 1 and vital capacity (VC). The adiponectin level had a positive correlation with the Tiffno index, FEF 50 , and peak expiratory flow (PEF). The NPY level had an inverse correlation with VC, FEV 1 , FEF 25 , FVC, Tiffno index, FEF 50 , and PEF. Conclusion: The severity of the clinical course of moderate asthma in obese patients is associated with different factors, including oxidative stress and levels of leptin, adiponectin and NPY.

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Asthma and metabolic syndrome: Clinical and pathogenetic relationships

Cited by 7 publications

References 31 publications

Physical Rehabilitation in Patients with Chronic Heart Failure and Chronic Obstructive Pulmonary Disease

Physical Rehabilitation in Patients with Chronic Heart Failure and Chronic Obstructive Pulmonary Disease

Physical Activity and Life Quality in Patients with Asthma and Osteoarthritis

Clinical Phenotype “Obesity-Asthma” as One of the Main Problems of Personalized Pulmonology

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